ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension

This article belongs to the Special Issue Antioxidant Properties and Potential Mechanisms of Protein Hydrolysates.

Detalhes bibliográficos
Autores: Luz Abreu, Edina da, Rodrigues Moro, Camila, Kanaan, Samia Hassan Husein, Bernardino de Paula, Ricardo, Teixeira Herrera, Camila, Dorneles Costa, Pedro Henrique, Peçanha, Franck Maciel, Vassallo, Dalton Valentim, Venturini Rossoni, Luciana, Miguel, Marta, Wiggers, Giulia Alessandra
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285187
Acesso em linha:http://hdl.handle.net/10261/285187
Access Level:acceso abierto
Palavra-chave:Egg white hydrolysate
Mitochondria
Hypertension
Oxidative stress
Deoxycorticosterone acetate (DOCA)-salt
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spelling ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertensionLuz Abreu, Edina daRodrigues Moro, CamilaKanaan, Samia Hassan HuseinBernardino de Paula, RicardoTeixeira Herrera, CamilaDorneles Costa, Pedro HenriquePeçanha, Franck MacielVassallo, Dalton ValentimVenturini Rossoni, LucianaMiguel, MartaWiggers, Giulia AlessandraEgg white hydrolysateMitochondriaHypertensionOxidative stressDeoxycorticosterone acetate (DOCA)-saltThis article belongs to the Special Issue Antioxidant Properties and Potential Mechanisms of Protein Hydrolysates.This study aimed to evaluate the potential for lowering blood pressure and beneficial effects on mesenteric resistance arteries (MRA) and conductance vessels (aorta) produced by dietary supplementation of an egg white hydrolysate (EWH) in rats with severe hypertension induced by deoxycorticosterone plus salt treatment (DOCA-salt), as well as the underlying mechanisms involved. The DOCA-salt model presented higher blood pressure, which was significantly reduced by EWH. The impaired acetylcholine-induced relaxation and eNOS expression observed in MRA and aorta from DOCA-salt rats was ameliorated by EWH. This effect on vessels (MRA and aorta) was related to the antioxidant effect of EWH, since hydrolysate intake prevented the NF-κB/TNFα inflammatory pathway and NADPH oxidase-induced reactive oxygen species (ROS) generation, as well as the mitochondrial source of ROS in MRA. At the plasma level, EWH blocked the higher ROS and MDA generation by DOCA-salt treatment, without altering the antioxidant marker. In conclusion, EWH demonstrated an antihypertensive effect in a model of severe hypertension. This effect could be related to its endothelium-dependent vasodilator properties mediated by an ameliorated vessel’s redox imbalance and inflammatory state.This work was supported by the National Council for Scientific and Technological Development—CNPq [Edital Universal/CNPq No 44181/2014-9 and PQ/CNPq 311834/2020-5]; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES); Fundação de Amparo à Pesquisa do Rio Grande do Sul—FAPERGS/Brazil [PQG:19/2551-0001810-0]; Programa Nacional de Cooperação Acadêmica; Pró-reitoria de Pesquisa—Universidade Federal do Pampa [N. 20180615102630]; FAPES/CNPq/PRONEX [N. 80598773], Foundation for Research Support of the State of Sao Paulo (FAPESP 2019/08026-5), and Spanish Goverment by the Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) [AGL2017-89213]; I-COOP+2020 (COOPA 20453). ELA were supported by CAPES/Brazil, CRM by FAPERGS/Brazil and PHD, CTH by Unipampa. LVR are research fellows from CNPq (312237/2021-9).Peer reviewedMultidisciplinary Digital Publishing InstituteConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)Fundação de Amparo à Pesquisa do Estado do Rio Grande do SulUniversidade Federal do PampaFundação de Amparo à Pesquisa do Estado de São PauloAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/285187reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89213-Rhttps://doi.org/10.3390/antiox11091713Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2851872026-05-22T06:33:51Z
dc.title.none.fl_str_mv ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
title ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
spellingShingle ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
Luz Abreu, Edina da
Egg white hydrolysate
Mitochondria
Hypertension
Oxidative stress
Deoxycorticosterone acetate (DOCA)-salt
title_short ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
title_full ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
title_fullStr ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
title_full_unstemmed ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
title_sort ROS suppression by egg white hydrolysate in DOCA-salt rats—An alternative tool against vascular dysfunction in severe hypertension
dc.creator.none.fl_str_mv Luz Abreu, Edina da
Rodrigues Moro, Camila
Kanaan, Samia Hassan Husein
Bernardino de Paula, Ricardo
Teixeira Herrera, Camila
Dorneles Costa, Pedro Henrique
Peçanha, Franck Maciel
Vassallo, Dalton Valentim
Venturini Rossoni, Luciana
Miguel, Marta
Wiggers, Giulia Alessandra
author Luz Abreu, Edina da
author_facet Luz Abreu, Edina da
Rodrigues Moro, Camila
Kanaan, Samia Hassan Husein
Bernardino de Paula, Ricardo
Teixeira Herrera, Camila
Dorneles Costa, Pedro Henrique
Peçanha, Franck Maciel
Vassallo, Dalton Valentim
Venturini Rossoni, Luciana
Miguel, Marta
Wiggers, Giulia Alessandra
author_role author
author2 Rodrigues Moro, Camila
Kanaan, Samia Hassan Husein
Bernardino de Paula, Ricardo
Teixeira Herrera, Camila
Dorneles Costa, Pedro Henrique
Peçanha, Franck Maciel
Vassallo, Dalton Valentim
Venturini Rossoni, Luciana
Miguel, Marta
Wiggers, Giulia Alessandra
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
Universidade Federal do Pampa
Fundação de Amparo à Pesquisa do Estado de São Paulo
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Egg white hydrolysate
Mitochondria
Hypertension
Oxidative stress
Deoxycorticosterone acetate (DOCA)-salt
topic Egg white hydrolysate
Mitochondria
Hypertension
Oxidative stress
Deoxycorticosterone acetate (DOCA)-salt
description This article belongs to the Special Issue Antioxidant Properties and Potential Mechanisms of Protein Hydrolysates.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285187
url http://hdl.handle.net/10261/285187
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89213-R
https://doi.org/10.3390/antiox11091713
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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