Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier

Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the 'Achiles' heels' of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanoc...

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Autores: Bonelli Blasco, Joaquin Daniel, Ortega Forte, Enrique, Rovira, Anna, Bosch Marimon, Manel, Torres, Oriol, Cuscó Marigó, Cristina, Rocas Sorolla, Josep, Ruiz, José, Marchán Sancho, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/190222
Acceso en línea:https://hdl.handle.net/2445/190222
Access Level:acceso abierto
Palabra clave:Cumarines
Polímers
Tumors
Coumarins
Polymers
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spelling Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid NanocarrierBonelli Blasco, Joaquin DanielOrtega Forte, EnriqueRovira, AnnaBosch Marimon, ManelTorres, OriolCuscó Marigó, CristinaRocas Sorolla, JosepRuiz, JoséMarchán Sancho, VicenteCumarinesPolímersTumorsCoumarinsPolymersTumorsIntegration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the 'Achiles' heels' of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with the aim of developing novel nanoPDT agents. The synthesis of coumarin-loaded NCs involved the nanoemulsification of a suitable prepolymer in the presence of a PS without needing external surfactants, and the resulting small nanoparticles showed improved photostability compared with the free compound. Nanoencapsulation reduced dark cytotoxicity of the coumarin PS and significantly improved in vitro photoactivity with red light toward cancer cells, which resulted in higher phototherapeutic indexes compared to free PS. Importantly, this nanoformulation impaired tumoral growth of clinically relevant three-dimensional multicellular tumor spheroids. Mitochondrial photodamage along with reactive oxygen species (ROS) photogeneration was found to trigger autophagy and apoptotic cell death of cancer cells.American Chemical Society2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/190222Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1021/acs.biomac.2c00361Biomacromolecules, 2022, vol. 23, num. 7, p. 2900-2913https://doi.org/10.1021/acs.biomac.2c00361cc-by (c) Bonelli, Joaquín et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1902222026-05-27T06:46:51Z
dc.title.none.fl_str_mv Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
title Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
spellingShingle Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
Bonelli Blasco, Joaquin Daniel
Cumarines
Polímers
Tumors
Coumarins
Polymers
Tumors
title_short Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
title_full Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
title_fullStr Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
title_full_unstemmed Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
title_sort Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
dc.creator.none.fl_str_mv Bonelli Blasco, Joaquin Daniel
Ortega Forte, Enrique
Rovira, Anna
Bosch Marimon, Manel
Torres, Oriol
Cuscó Marigó, Cristina
Rocas Sorolla, Josep
Ruiz, José
Marchán Sancho, Vicente
author Bonelli Blasco, Joaquin Daniel
author_facet Bonelli Blasco, Joaquin Daniel
Ortega Forte, Enrique
Rovira, Anna
Bosch Marimon, Manel
Torres, Oriol
Cuscó Marigó, Cristina
Rocas Sorolla, Josep
Ruiz, José
Marchán Sancho, Vicente
author_role author
author2 Ortega Forte, Enrique
Rovira, Anna
Bosch Marimon, Manel
Torres, Oriol
Cuscó Marigó, Cristina
Rocas Sorolla, Josep
Ruiz, José
Marchán Sancho, Vicente
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cumarines
Polímers
Tumors
Coumarins
Polymers
Tumors
topic Cumarines
Polímers
Tumors
Coumarins
Polymers
Tumors
description Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the 'Achiles' heels' of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with the aim of developing novel nanoPDT agents. The synthesis of coumarin-loaded NCs involved the nanoemulsification of a suitable prepolymer in the presence of a PS without needing external surfactants, and the resulting small nanoparticles showed improved photostability compared with the free compound. Nanoencapsulation reduced dark cytotoxicity of the coumarin PS and significantly improved in vitro photoactivity with red light toward cancer cells, which resulted in higher phototherapeutic indexes compared to free PS. Importantly, this nanoformulation impaired tumoral growth of clinically relevant three-dimensional multicellular tumor spheroids. Mitochondrial photodamage along with reactive oxygen species (ROS) photogeneration was found to trigger autophagy and apoptotic cell death of cancer cells.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/190222
url https://hdl.handle.net/2445/190222
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1021/acs.biomac.2c00361
Biomacromolecules, 2022, vol. 23, num. 7, p. 2900-2913
https://doi.org/10.1021/acs.biomac.2c00361
dc.rights.none.fl_str_mv cc-by (c) Bonelli, Joaquín et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bonelli, Joaquín et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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