Development of a new 3D hybrid model for epithelia morphogenesis

Many epithelial developmental processes like cell migration and spreading, cell sorting, or T1 transitions can be described as planar deformations. As such, they can be studied using two-dimensional tools and vertex models that can properly predict collective dynamics. However, many other epithelial...

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Detalles Bibliográficos
Autores: Ioannou, Filippos, Dawi, Malik Ali A., Tetley, Rob, Mao, Yanlan, Muñoz Romero, José|||0000-0002-0083-3673
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/342609
Acceso en línea:https://hdl.handle.net/2117/342609
https://dx.doi.org/10.3389/fbioe.2020.00405
Access Level:acceso abierto
Palabra clave:Bioengineering
Biotechnology
Numerical calculations
Bioenginyeria
Biotecnologia
Càlculs numèrics
Àrees temàtiques de la UPC::Matemàtiques i estadística
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repository_id_str
spelling Development of a new 3D hybrid model for epithelia morphogenesisIoannou, FilipposDawi, Malik Ali A.Tetley, RobMao, YanlanMuñoz Romero, José|||0000-0002-0083-3673BioengineeringBiotechnologyNumerical calculationsBioenginyeriaBiotecnologiaCàlculs numèricsÀrees temàtiques de la UPC::Matemàtiques i estadísticaMany epithelial developmental processes like cell migration and spreading, cell sorting, or T1 transitions can be described as planar deformations. As such, they can be studied using two-dimensional tools and vertex models that can properly predict collective dynamics. However, many other epithelial shape changes are characterized by out-of-plane mechanics and three-dimensional effects, such as bending, cell extrusion, delamination, or invagination. Furthermore, during planar cell dynamics or tissue repair in monolayers, spatial intercalation between the apical and basal sides has even been detected. Motivated by this lack of symmetry with respect to the midsurface, we here present a 3D hybrid model that allows us to model differential contractility at the apical, basal or lateral sides. We use the model to study the effects on wound closure of solely apical or lateral contractile contributions and show that an apical purse-string can be sufficient for full closure when it is accompanied by volume preservation.Peer ReviewedFrontiers Media SA20202020-05-0520212021-03-26journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/342609https://dx.doi.org/10.3389/fbioe.2020.00405reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3426092026-05-27T15:37:01Z
dc.title.none.fl_str_mv Development of a new 3D hybrid model for epithelia morphogenesis
title Development of a new 3D hybrid model for epithelia morphogenesis
spellingShingle Development of a new 3D hybrid model for epithelia morphogenesis
Ioannou, Filippos
Bioengineering
Biotechnology
Numerical calculations
Bioenginyeria
Biotecnologia
Càlculs numèrics
Àrees temàtiques de la UPC::Matemàtiques i estadística
title_short Development of a new 3D hybrid model for epithelia morphogenesis
title_full Development of a new 3D hybrid model for epithelia morphogenesis
title_fullStr Development of a new 3D hybrid model for epithelia morphogenesis
title_full_unstemmed Development of a new 3D hybrid model for epithelia morphogenesis
title_sort Development of a new 3D hybrid model for epithelia morphogenesis
dc.creator.none.fl_str_mv Ioannou, Filippos
Dawi, Malik Ali A.
Tetley, Rob
Mao, Yanlan
Muñoz Romero, José|||0000-0002-0083-3673
author Ioannou, Filippos
author_facet Ioannou, Filippos
Dawi, Malik Ali A.
Tetley, Rob
Mao, Yanlan
Muñoz Romero, José|||0000-0002-0083-3673
author_role author
author2 Dawi, Malik Ali A.
Tetley, Rob
Mao, Yanlan
Muñoz Romero, José|||0000-0002-0083-3673
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bioengineering
Biotechnology
Numerical calculations
Bioenginyeria
Biotecnologia
Càlculs numèrics
Àrees temàtiques de la UPC::Matemàtiques i estadística
topic Bioengineering
Biotechnology
Numerical calculations
Bioenginyeria
Biotecnologia
Càlculs numèrics
Àrees temàtiques de la UPC::Matemàtiques i estadística
description Many epithelial developmental processes like cell migration and spreading, cell sorting, or T1 transitions can be described as planar deformations. As such, they can be studied using two-dimensional tools and vertex models that can properly predict collective dynamics. However, many other epithelial shape changes are characterized by out-of-plane mechanics and three-dimensional effects, such as bending, cell extrusion, delamination, or invagination. Furthermore, during planar cell dynamics or tissue repair in monolayers, spatial intercalation between the apical and basal sides has even been detected. Motivated by this lack of symmetry with respect to the midsurface, we here present a 3D hybrid model that allows us to model differential contractility at the apical, basal or lateral sides. We use the model to study the effects on wound closure of solely apical or lateral contractile contributions and show that an apical purse-string can be sufficient for full closure when it is accompanied by volume preservation.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-05-05
2021
2021-03-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/342609
https://dx.doi.org/10.3389/fbioe.2020.00405
url https://hdl.handle.net/2117/342609
https://dx.doi.org/10.3389/fbioe.2020.00405
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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