Cellular innate immunity against PRRSV and swine influenza viruses

Porcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and produc...

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Authors: Crisci, Elisa, Fraile Sauce, Lorenzo José, Montoya, Maria
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Universitat de Lleida (UdL)
Repository:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/68297
Online Access:https://doi.org/10.3390/vetsci6010026
http://hdl.handle.net/10459.1/68297
Access Level:Open access
Keyword:Pig
Innate immunity
PRRSV
Swine influenza virus
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spelling Cellular innate immunity against PRRSV and swine influenza virusesCrisci, ElisaFraile Sauce, Lorenzo JoséMontoya, MariaPigInnate immunityPRRSVSwine influenza virusPorcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and production costs in the pig industry worldwide. This review focuses on the interactions of two enveloped RNA viruses—porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SwIV)—as major etiological agents that contribute to PRDC within the porcine cellular innate immunity during infection. The innate immune system of the porcine lung includes alveolar and parenchymal/interstitial macrophages, neutrophils (PMN), conventional dendritic cells (DC) and plasmacytoid DC, natural killer cells, and γδ T cells, thus the in vitro and in vivo interactions between those cells and PRRSV and SwIV are reviewed. Likewise, the few studies regarding PRRSV-SwIV co-infection are illustrated together with the different modulation mechanisms that are induced by the two viruses. Alterations in responses by natural killer (NK), PMN, or γδ T cells have not received much attention within the scientific community as their counterpart antigen-presenting cells and there are numerous gaps in the knowledge regarding the role of those cells in both infections. This review will help in paving the way for future directions in PRRSV and SwIV research and enhancing the understanding of the innate mechanisms that are involved during infection with these viruses.This research was funded by CSIC.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/vetsci6010026http://hdl.handle.net/10459.1/68297reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.3390/vetsci6010026Veterinary Sciences, 2019, vol. 6, núm. 1, article number 26, p. 1-26cc-by (c) Crisci, Elisa et al., 2019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/682972026-06-24T12:42:17Z
dc.title.none.fl_str_mv Cellular innate immunity against PRRSV and swine influenza viruses
title Cellular innate immunity against PRRSV and swine influenza viruses
spellingShingle Cellular innate immunity against PRRSV and swine influenza viruses
Crisci, Elisa
Pig
Innate immunity
PRRSV
Swine influenza virus
title_short Cellular innate immunity against PRRSV and swine influenza viruses
title_full Cellular innate immunity against PRRSV and swine influenza viruses
title_fullStr Cellular innate immunity against PRRSV and swine influenza viruses
title_full_unstemmed Cellular innate immunity against PRRSV and swine influenza viruses
title_sort Cellular innate immunity against PRRSV and swine influenza viruses
dc.creator.none.fl_str_mv Crisci, Elisa
Fraile Sauce, Lorenzo José
Montoya, Maria
author Crisci, Elisa
author_facet Crisci, Elisa
Fraile Sauce, Lorenzo José
Montoya, Maria
author_role author
author2 Fraile Sauce, Lorenzo José
Montoya, Maria
author2_role author
author
dc.subject.none.fl_str_mv Pig
Innate immunity
PRRSV
Swine influenza virus
topic Pig
Innate immunity
PRRSV
Swine influenza virus
description Porcine respiratory disease complex (PRDC) is a polymicrobial syndrome that results from a combination of infectious agents, such as environmental stressors, population size, management strategies, age, and genetics. PRDC results in reduced performance as well as increased mortality rates and production costs in the pig industry worldwide. This review focuses on the interactions of two enveloped RNA viruses—porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SwIV)—as major etiological agents that contribute to PRDC within the porcine cellular innate immunity during infection. The innate immune system of the porcine lung includes alveolar and parenchymal/interstitial macrophages, neutrophils (PMN), conventional dendritic cells (DC) and plasmacytoid DC, natural killer cells, and γδ T cells, thus the in vitro and in vivo interactions between those cells and PRRSV and SwIV are reviewed. Likewise, the few studies regarding PRRSV-SwIV co-infection are illustrated together with the different modulation mechanisms that are induced by the two viruses. Alterations in responses by natural killer (NK), PMN, or γδ T cells have not received much attention within the scientific community as their counterpart antigen-presenting cells and there are numerous gaps in the knowledge regarding the role of those cells in both infections. This review will help in paving the way for future directions in PRRSV and SwIV research and enhancing the understanding of the innate mechanisms that are involved during infection with these viruses.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/vetsci6010026
http://hdl.handle.net/10459.1/68297
url https://doi.org/10.3390/vetsci6010026
http://hdl.handle.net/10459.1/68297
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/vetsci6010026
Veterinary Sciences, 2019, vol. 6, núm. 1, article number 26, p. 1-26
dc.rights.none.fl_str_mv cc-by (c) Crisci, Elisa et al., 2019
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Crisci, Elisa et al., 2019
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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