Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity

In the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory...

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Detalhes bibliográficos
Autores: Matesanz Sancho, María Concepción, Linares, Javier, Lilue, Isabel, Sánchez Salcedo, Sandra, Feito Castellano, María José, Arcos Navarrete, Daniel, Vallet Regí, María Dulce Nombre, Portolés Pérez, María Teresa
Tipo de documento: artigo
Data de publicação:2014
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/35368
Acesso em linha:https://hdl.handle.net/20.500.14352/35368
Access Level:Acceso aberto
Palavra-chave:546
615.46
Osteoblast-like cells
Bone-resorption
In-vitro
Molecular-mechanisms
Osteoporosis
Macrophages
Vivo
Biomaterials
Bioceramics
Inhibitors
Química
Materiales
Química inorgánica (Química)
23 Química
3312 Tecnología de Materiales
2303 Química Inorgánica
id ES_2b2f87527132ddb2b0b39ae06b9ee6d2
oai_identifier_str oai:docta.ucm.es:20.500.14352/35368
network_acronym_str ES
network_name_str España
repository_id_str
spelling Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activityMatesanz Sancho, María ConcepciónLinares, JavierLilue, IsabelSánchez Salcedo, SandraFeito Castellano, María JoséArcos Navarrete, DanielVallet Regí, María Dulce NombrePortolés Pérez, María Teresa546615.46Osteoblast-like cellsBone-resorptionIn-vitroMolecular-mechanismsOsteoporosisMacrophagesVivoBiomaterialsBioceramicsInhibitorsQuímicaMaterialesQuímica inorgánica (Química)23 Química3312 Tecnología de Materiales2303 Química InorgánicaIn the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory and reparative macrophage populations was also studied. Nano-SiHA disks delayed the osteoclast differentiation and decreased the resorptive activity of these cells on their surface, as compared to nano-HA samples, without affecting cell viability. Powdered nano-SiHA also induced an increase of the reparative macrophage population. These results along with the beneficial effects on osteoblasts previously observed with powdered nano-SiHA suggest the potential of this biomaterial for modulating the fundamental processes of bone formation and turnover, preventing bone resorption and enhancing bone formation at implantation sites in treatment of osteoporotic bone and in bone repair and regeneration.Royal Society of ChemistryUniversidad Complutense de Madrid20142014-05-2120142014-05-21journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/35368reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/353682026-06-02T12:44:21Z
dc.title.none.fl_str_mv Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
title Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
spellingShingle Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
Matesanz Sancho, María Concepción
546
615.46
Osteoblast-like cells
Bone-resorption
In-vitro
Molecular-mechanisms
Osteoporosis
Macrophages
Vivo
Biomaterials
Bioceramics
Inhibitors
Química
Materiales
Química inorgánica (Química)
23 Química
3312 Tecnología de Materiales
2303 Química Inorgánica
title_short Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
title_full Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
title_fullStr Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
title_full_unstemmed Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
title_sort Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity
dc.creator.none.fl_str_mv Matesanz Sancho, María Concepción
Linares, Javier
Lilue, Isabel
Sánchez Salcedo, Sandra
Feito Castellano, María José
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
Portolés Pérez, María Teresa
author Matesanz Sancho, María Concepción
author_facet Matesanz Sancho, María Concepción
Linares, Javier
Lilue, Isabel
Sánchez Salcedo, Sandra
Feito Castellano, María José
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
Portolés Pérez, María Teresa
author_role author
author2 Linares, Javier
Lilue, Isabel
Sánchez Salcedo, Sandra
Feito Castellano, María José
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
Portolés Pérez, María Teresa
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 546
615.46
Osteoblast-like cells
Bone-resorption
In-vitro
Molecular-mechanisms
Osteoporosis
Macrophages
Vivo
Biomaterials
Bioceramics
Inhibitors
Química
Materiales
Química inorgánica (Química)
23 Química
3312 Tecnología de Materiales
2303 Química Inorgánica
topic 546
615.46
Osteoblast-like cells
Bone-resorption
In-vitro
Molecular-mechanisms
Osteoporosis
Macrophages
Vivo
Biomaterials
Bioceramics
Inhibitors
Química
Materiales
Química inorgánica (Química)
23 Química
3312 Tecnología de Materiales
2303 Química Inorgánica
description In the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory and reparative macrophage populations was also studied. Nano-SiHA disks delayed the osteoclast differentiation and decreased the resorptive activity of these cells on their surface, as compared to nano-HA samples, without affecting cell viability. Powdered nano-SiHA also induced an increase of the reparative macrophage population. These results along with the beneficial effects on osteoblasts previously observed with powdered nano-SiHA suggest the potential of this biomaterial for modulating the fundamental processes of bone formation and turnover, preventing bone resorption and enhancing bone formation at implantation sites in treatment of osteoporotic bone and in bone repair and regeneration.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-05-21
2014
2014-05-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/35368
url https://hdl.handle.net/20.500.14352/35368
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405128422850560
score 15.300719

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