O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Gonzalez-Rellan, M.J. (María J.)|||/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75; Fondevila, M.F. (Marcos F.)|||/items/42515fd5-cb1f-44a3-99aa-b643d79de50b; Fernández, U. (Uxía)|||/items/b5339a5a-3803-4411-b618-ee1c94654657; Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427; Varela-Rey, M. (Marta)|||/items/c142211c-bbe7-4b40-a3ad-8d17134ee686; Veyrat-Durebex, C. (Christelle)|||/items/9d98726e-c438-4ce5-8934-f502d9067ba2; Seoane, S. (Samuel)|||/items/04b32e0a-25e4-447c-b714-db1895887045; Bernardo, G. (Ganeko)|||/items/5ef92288-af4e-4e5a-b1d0-ce00708cc8bd; Lopitz-Otsoa, F. (Fernando)|||/items/5e18ab21-ac81-4254-ae11-9dc9d3213e80; Fernández-Ramos, D. (David)|||/items/d5e19220-54fe-4552-ad3a-5bb8150cd786; Bilbao, J. (Jon)|||/items/d558ad14-d0b1-4ff0-aa00-e36ee854dac5; Iglesias, C. (Cristina)|||/items/6c293a8c-e822-45bd-a55f-19dd42bf8d05; Novoa, E. (Eva)|||/items/766fd1b8-02a2-455c-9709-c565201be738; Ameneiro, C. (Cristina)|||/items/a8899de9-19dd-41f5-ba90-2571cbdd9584; Senra, A. (Ana)|||/items/f48cb1cd-d1eb-46d4-abc6-c985f6e23cc4; Beiroa, D. (Daniel)|||/items/59b676a1-cbf0-4dd2-9e87-f0fe518e14c6; Cuñarro, J. (Juan)|||/items/4f31a7ee-5d63-48a5-8589-937b1e064278; Chantada-Vazquez, M.D.P. (Maria D.P.)|||/items/ff0d8bb2-d9b0-489c-9d52-bd1a40b63be9; Garcia-Vence, M. (Maria)|||/items/fd3ba38b-869c-4687-a7a7-f3399700e5eb; Bravo, S. (Susana B.)|||/items/e01e519b-f836-4fcb-86d7-31112734e8e2; da-Silva-Lima, N. (Natalia)|||/items/9e088f99-dea7-42cf-8026-21c1027c1af8; Porteiro, B. (Begoña)|||/items/a0469e98-1bfb-4768-ada9-24573be6f1cb; Carneiro, C. (Carmen)|||/items/5705da5b-e5cb-48ec-9ec5-746f1fe2c0ec; Vidal, A. (Anxo)|||/items/a8facbdb-e501-4b94-9e61-fa3244770258; Tovar, S. (Sulay)|||/items/5716a149-8ad6-45d3-b30b-4f67d30cd2fb; Müller, T.D. (Timo D.)|||/items/e61aad48-a7c8-45a7-b479-6358a9659fa6; Ferno, J. (Johan)|||/items/6babd121-81a7-41ca-8d0c-edbea833d10b; Guallar, D. (Diana)|||/items/1dc9d5a7-af90-4a94-86a4-9e3e6b3d4058; Fidalgo, M. (Miguel)|||/items/35c79a24-3ecd-498b-bc11-3a43ce977d46; Sabio, G. (Guadalupe)|||/items/f04ae0a3-ab59-4e44-b814-5e413bd5584d; Herzig, S. (Stephan)|||/items/386d0e63-7570-43c0-8777-8098a62b5396; Yang, W.H. (Won Ho)|||/items/77c8f762-1c9c-4381-ab12-c79d2e8e209f; Cho, J.W. (Jin Won)|||/items/32b24e5d-69d2-4de8-821d-139899127fbe; Martinez-Chantar, M.L. (María Luz)|||/items/df06120b-2a53-4074-a155-638f899b2ce5; Perez-Fernandez, R. (Roman)|||/items/91f47f3e-1252-4e50-8446-0da3888e794d; López-Yoldi, M. (Miguel)|||/items/d3db8959-5c7f-4257-8a0a-b2374e5da832; Dieguez, C. (Carlos)|||/items/54b49b82-82ec-4bb6-9d48-c54fb1d572fb; Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79; Millet, O. (Oscar)|||/items/d6bbd577-a3c4-4f18-9dc5-1686de0e0489; Coppari, R. (Roberto)|||/items/0aab48ad-95e3-4a9b-aead-c2edc24d5433; Woodhoo, A. (Ashwin)|||/items/a9e90cb2-bac1-43fb-a0b2-5e3409f9c860; Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b; Nogueiras, R. (Rubén)|||/items/d6d4c851-6ed5-47d3-9361-c80bbfae88e6

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could be linked to glucose maintenance. We show here that upon starv...

Descripción completa

Detalles Bibliográficos
Autores:	Gonzalez-Rellan, M.J. (María J.)\|\|\|/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75, Fondevila, M.F. (Marcos F.)\|\|\|/items/42515fd5-cb1f-44a3-99aa-b643d79de50b, Fernández, U. (Uxía)\|\|\|/items/b5339a5a-3803-4411-b618-ee1c94654657, Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427, Varela-Rey, M. (Marta)\|\|\|/items/c142211c-bbe7-4b40-a3ad-8d17134ee686, Veyrat-Durebex, C. (Christelle)\|\|\|/items/9d98726e-c438-4ce5-8934-f502d9067ba2, Seoane, S. (Samuel)\|\|\|/items/04b32e0a-25e4-447c-b714-db1895887045, Bernardo, G. (Ganeko)\|\|\|/items/5ef92288-af4e-4e5a-b1d0-ce00708cc8bd, Lopitz-Otsoa, F. (Fernando)\|\|\|/items/5e18ab21-ac81-4254-ae11-9dc9d3213e80, Fernández-Ramos, D. (David)\|\|\|/items/d5e19220-54fe-4552-ad3a-5bb8150cd786, Bilbao, J. (Jon)\|\|\|/items/d558ad14-d0b1-4ff0-aa00-e36ee854dac5, Iglesias, C. (Cristina)\|\|\|/items/6c293a8c-e822-45bd-a55f-19dd42bf8d05, Novoa, E. (Eva)\|\|\|/items/766fd1b8-02a2-455c-9709-c565201be738, Ameneiro, C. (Cristina)\|\|\|/items/a8899de9-19dd-41f5-ba90-2571cbdd9584, Senra, A. (Ana)\|\|\|/items/f48cb1cd-d1eb-46d4-abc6-c985f6e23cc4, Beiroa, D. (Daniel)\|\|\|/items/59b676a1-cbf0-4dd2-9e87-f0fe518e14c6, Cuñarro, J. (Juan)\|\|\|/items/4f31a7ee-5d63-48a5-8589-937b1e064278, Chantada-Vazquez, M.D.P. (Maria D.P.)\|\|\|/items/ff0d8bb2-d9b0-489c-9d52-bd1a40b63be9, Garcia-Vence, M. (Maria)\|\|\|/items/fd3ba38b-869c-4687-a7a7-f3399700e5eb, Bravo, S. (Susana B.)\|\|\|/items/e01e519b-f836-4fcb-86d7-31112734e8e2, da-Silva-Lima, N. (Natalia)\|\|\|/items/9e088f99-dea7-42cf-8026-21c1027c1af8, Porteiro, B. (Begoña)\|\|\|/items/a0469e98-1bfb-4768-ada9-24573be6f1cb, Carneiro, C. (Carmen)\|\|\|/items/5705da5b-e5cb-48ec-9ec5-746f1fe2c0ec, Vidal, A. (Anxo)\|\|\|/items/a8facbdb-e501-4b94-9e61-fa3244770258, Tovar, S. (Sulay)\|\|\|/items/5716a149-8ad6-45d3-b30b-4f67d30cd2fb, Müller, T.D. (Timo D.)\|\|\|/items/e61aad48-a7c8-45a7-b479-6358a9659fa6, Ferno, J. (Johan)\|\|\|/items/6babd121-81a7-41ca-8d0c-edbea833d10b, Guallar, D. (Diana)\|\|\|/items/1dc9d5a7-af90-4a94-86a4-9e3e6b3d4058, Fidalgo, M. (Miguel)\|\|\|/items/35c79a24-3ecd-498b-bc11-3a43ce977d46, Sabio, G. (Guadalupe)\|\|\|/items/f04ae0a3-ab59-4e44-b814-5e413bd5584d, Herzig, S. (Stephan)\|\|\|/items/386d0e63-7570-43c0-8777-8098a62b5396, Yang, W.H. (Won Ho)\|\|\|/items/77c8f762-1c9c-4381-ab12-c79d2e8e209f, Cho, J.W. (Jin Won)\|\|\|/items/32b24e5d-69d2-4de8-821d-139899127fbe, Martinez-Chantar, M.L. (María Luz)\|\|\|/items/df06120b-2a53-4074-a155-638f899b2ce5, Perez-Fernandez, R. (Roman)\|\|\|/items/91f47f3e-1252-4e50-8446-0da3888e794d, López-Yoldi, M. (Miguel)\|\|\|/items/d3db8959-5c7f-4257-8a0a-b2374e5da832, Dieguez, C. (Carlos)\|\|\|/items/54b49b82-82ec-4bb6-9d48-c54fb1d572fb, Mato, J.M. (José María)\|\|\|/items/302dc624-b0d3-4703-90cf-1a97690ebc79, Millet, O. (Oscar)\|\|\|/items/d6bbd577-a3c4-4f18-9dc5-1686de0e0489, Coppari, R. (Roberto)\|\|\|/items/0aab48ad-95e3-4a9b-aead-c2edc24d5433, Woodhoo, A. (Ashwin)\|\|\|/items/a9e90cb2-bac1-43fb-a0b2-5e3409f9c860, Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b, Nogueiras, R. (Rubén)\|\|\|/items/d6d4c851-6ed5-47d3-9361-c80bbfae88e6
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/114713
Acceso en línea:	https://hdl.handle.net/10171/114713
Access Level:	acceso abierto
Palabra clave:	P53 Metabolic homeostasis of cells Response to stress

id	ES_2b2bbb6409b6b1ed1ff12e5203b7618b
oai_identifier_str	oai:dadun.unav.edu:10171/114713
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
title	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
spellingShingle	O-GlcNAcylated p53 in the liver modulates hepatic glucose production Gonzalez-Rellan, M.J. (María J.)\|\|\|/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75 P53 Metabolic homeostasis of cells Response to stress
title_short	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
title_full	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
title_fullStr	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
title_full_unstemmed	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
title_sort	O-GlcNAcylated p53 in the liver modulates hepatic glucose production
dc.creator.none.fl_str_mv	Gonzalez-Rellan, M.J. (María J.)\|\|\|/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75 Fondevila, M.F. (Marcos F.)\|\|\|/items/42515fd5-cb1f-44a3-99aa-b643d79de50b Fernández, U. (Uxía)\|\|\|/items/b5339a5a-3803-4411-b618-ee1c94654657 Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427 Varela-Rey, M. (Marta)\|\|\|/items/c142211c-bbe7-4b40-a3ad-8d17134ee686 Veyrat-Durebex, C. (Christelle)\|\|\|/items/9d98726e-c438-4ce5-8934-f502d9067ba2 Seoane, S. (Samuel)\|\|\|/items/04b32e0a-25e4-447c-b714-db1895887045 Bernardo, G. (Ganeko)\|\|\|/items/5ef92288-af4e-4e5a-b1d0-ce00708cc8bd Lopitz-Otsoa, F. (Fernando)\|\|\|/items/5e18ab21-ac81-4254-ae11-9dc9d3213e80 Fernández-Ramos, D. (David)\|\|\|/items/d5e19220-54fe-4552-ad3a-5bb8150cd786 Bilbao, J. (Jon)\|\|\|/items/d558ad14-d0b1-4ff0-aa00-e36ee854dac5 Iglesias, C. (Cristina)\|\|\|/items/6c293a8c-e822-45bd-a55f-19dd42bf8d05 Novoa, E. (Eva)\|\|\|/items/766fd1b8-02a2-455c-9709-c565201be738 Ameneiro, C. (Cristina)\|\|\|/items/a8899de9-19dd-41f5-ba90-2571cbdd9584 Senra, A. (Ana)\|\|\|/items/f48cb1cd-d1eb-46d4-abc6-c985f6e23cc4 Beiroa, D. (Daniel)\|\|\|/items/59b676a1-cbf0-4dd2-9e87-f0fe518e14c6 Cuñarro, J. (Juan)\|\|\|/items/4f31a7ee-5d63-48a5-8589-937b1e064278 Chantada-Vazquez, M.D.P. (Maria D.P.)\|\|\|/items/ff0d8bb2-d9b0-489c-9d52-bd1a40b63be9 Garcia-Vence, M. (Maria)\|\|\|/items/fd3ba38b-869c-4687-a7a7-f3399700e5eb Bravo, S. (Susana B.)\|\|\|/items/e01e519b-f836-4fcb-86d7-31112734e8e2 da-Silva-Lima, N. (Natalia)\|\|\|/items/9e088f99-dea7-42cf-8026-21c1027c1af8 Porteiro, B. (Begoña)\|\|\|/items/a0469e98-1bfb-4768-ada9-24573be6f1cb Carneiro, C. (Carmen)\|\|\|/items/5705da5b-e5cb-48ec-9ec5-746f1fe2c0ec Vidal, A. (Anxo)\|\|\|/items/a8facbdb-e501-4b94-9e61-fa3244770258 Tovar, S. (Sulay)\|\|\|/items/5716a149-8ad6-45d3-b30b-4f67d30cd2fb Müller, T.D. (Timo D.)\|\|\|/items/e61aad48-a7c8-45a7-b479-6358a9659fa6 Ferno, J. (Johan)\|\|\|/items/6babd121-81a7-41ca-8d0c-edbea833d10b Guallar, D. (Diana)\|\|\|/items/1dc9d5a7-af90-4a94-86a4-9e3e6b3d4058 Fidalgo, M. (Miguel)\|\|\|/items/35c79a24-3ecd-498b-bc11-3a43ce977d46 Sabio, G. (Guadalupe)\|\|\|/items/f04ae0a3-ab59-4e44-b814-5e413bd5584d Herzig, S. (Stephan)\|\|\|/items/386d0e63-7570-43c0-8777-8098a62b5396 Yang, W.H. (Won Ho)\|\|\|/items/77c8f762-1c9c-4381-ab12-c79d2e8e209f Cho, J.W. (Jin Won)\|\|\|/items/32b24e5d-69d2-4de8-821d-139899127fbe Martinez-Chantar, M.L. (María Luz)\|\|\|/items/df06120b-2a53-4074-a155-638f899b2ce5 Perez-Fernandez, R. (Roman)\|\|\|/items/91f47f3e-1252-4e50-8446-0da3888e794d López-Yoldi, M. (Miguel)\|\|\|/items/d3db8959-5c7f-4257-8a0a-b2374e5da832 Dieguez, C. (Carlos)\|\|\|/items/54b49b82-82ec-4bb6-9d48-c54fb1d572fb Mato, J.M. (José María)\|\|\|/items/302dc624-b0d3-4703-90cf-1a97690ebc79 Millet, O. (Oscar)\|\|\|/items/d6bbd577-a3c4-4f18-9dc5-1686de0e0489 Coppari, R. (Roberto)\|\|\|/items/0aab48ad-95e3-4a9b-aead-c2edc24d5433 Woodhoo, A. (Ashwin)\|\|\|/items/a9e90cb2-bac1-43fb-a0b2-5e3409f9c860 Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Nogueiras, R. (Rubén)\|\|\|/items/d6d4c851-6ed5-47d3-9361-c80bbfae88e6
author	Gonzalez-Rellan, M.J. (María J.)\|\|\|/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75
author_facet	Gonzalez-Rellan, M.J. (María J.)\|\|\|/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75 Fondevila, M.F. (Marcos F.)\|\|\|/items/42515fd5-cb1f-44a3-99aa-b643d79de50b Fernández, U. (Uxía)\|\|\|/items/b5339a5a-3803-4411-b618-ee1c94654657 Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427 Varela-Rey, M. (Marta)\|\|\|/items/c142211c-bbe7-4b40-a3ad-8d17134ee686 Veyrat-Durebex, C. (Christelle)\|\|\|/items/9d98726e-c438-4ce5-8934-f502d9067ba2 Seoane, S. (Samuel)\|\|\|/items/04b32e0a-25e4-447c-b714-db1895887045 Bernardo, G. (Ganeko)\|\|\|/items/5ef92288-af4e-4e5a-b1d0-ce00708cc8bd Lopitz-Otsoa, F. (Fernando)\|\|\|/items/5e18ab21-ac81-4254-ae11-9dc9d3213e80 Fernández-Ramos, D. (David)\|\|\|/items/d5e19220-54fe-4552-ad3a-5bb8150cd786 Bilbao, J. (Jon)\|\|\|/items/d558ad14-d0b1-4ff0-aa00-e36ee854dac5 Iglesias, C. (Cristina)\|\|\|/items/6c293a8c-e822-45bd-a55f-19dd42bf8d05 Novoa, E. (Eva)\|\|\|/items/766fd1b8-02a2-455c-9709-c565201be738 Ameneiro, C. (Cristina)\|\|\|/items/a8899de9-19dd-41f5-ba90-2571cbdd9584 Senra, A. (Ana)\|\|\|/items/f48cb1cd-d1eb-46d4-abc6-c985f6e23cc4 Beiroa, D. (Daniel)\|\|\|/items/59b676a1-cbf0-4dd2-9e87-f0fe518e14c6 Cuñarro, J. (Juan)\|\|\|/items/4f31a7ee-5d63-48a5-8589-937b1e064278 Chantada-Vazquez, M.D.P. (Maria D.P.)\|\|\|/items/ff0d8bb2-d9b0-489c-9d52-bd1a40b63be9 Garcia-Vence, M. (Maria)\|\|\|/items/fd3ba38b-869c-4687-a7a7-f3399700e5eb Bravo, S. (Susana B.)\|\|\|/items/e01e519b-f836-4fcb-86d7-31112734e8e2 da-Silva-Lima, N. (Natalia)\|\|\|/items/9e088f99-dea7-42cf-8026-21c1027c1af8 Porteiro, B. (Begoña)\|\|\|/items/a0469e98-1bfb-4768-ada9-24573be6f1cb Carneiro, C. (Carmen)\|\|\|/items/5705da5b-e5cb-48ec-9ec5-746f1fe2c0ec Vidal, A. (Anxo)\|\|\|/items/a8facbdb-e501-4b94-9e61-fa3244770258 Tovar, S. (Sulay)\|\|\|/items/5716a149-8ad6-45d3-b30b-4f67d30cd2fb Müller, T.D. (Timo D.)\|\|\|/items/e61aad48-a7c8-45a7-b479-6358a9659fa6 Ferno, J. (Johan)\|\|\|/items/6babd121-81a7-41ca-8d0c-edbea833d10b Guallar, D. (Diana)\|\|\|/items/1dc9d5a7-af90-4a94-86a4-9e3e6b3d4058 Fidalgo, M. (Miguel)\|\|\|/items/35c79a24-3ecd-498b-bc11-3a43ce977d46 Sabio, G. (Guadalupe)\|\|\|/items/f04ae0a3-ab59-4e44-b814-5e413bd5584d Herzig, S. (Stephan)\|\|\|/items/386d0e63-7570-43c0-8777-8098a62b5396 Yang, W.H. (Won Ho)\|\|\|/items/77c8f762-1c9c-4381-ab12-c79d2e8e209f Cho, J.W. (Jin Won)\|\|\|/items/32b24e5d-69d2-4de8-821d-139899127fbe Martinez-Chantar, M.L. (María Luz)\|\|\|/items/df06120b-2a53-4074-a155-638f899b2ce5 Perez-Fernandez, R. (Roman)\|\|\|/items/91f47f3e-1252-4e50-8446-0da3888e794d López-Yoldi, M. (Miguel)\|\|\|/items/d3db8959-5c7f-4257-8a0a-b2374e5da832 Dieguez, C. (Carlos)\|\|\|/items/54b49b82-82ec-4bb6-9d48-c54fb1d572fb Mato, J.M. (José María)\|\|\|/items/302dc624-b0d3-4703-90cf-1a97690ebc79 Millet, O. (Oscar)\|\|\|/items/d6bbd577-a3c4-4f18-9dc5-1686de0e0489 Coppari, R. (Roberto)\|\|\|/items/0aab48ad-95e3-4a9b-aead-c2edc24d5433 Woodhoo, A. (Ashwin)\|\|\|/items/a9e90cb2-bac1-43fb-a0b2-5e3409f9c860 Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Nogueiras, R. (Rubén)\|\|\|/items/d6d4c851-6ed5-47d3-9361-c80bbfae88e6
author_role	author
author2	Fondevila, M.F. (Marcos F.)\|\|\|/items/42515fd5-cb1f-44a3-99aa-b643d79de50b Fernández, U. (Uxía)\|\|\|/items/b5339a5a-3803-4411-b618-ee1c94654657 Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427 Varela-Rey, M. (Marta)\|\|\|/items/c142211c-bbe7-4b40-a3ad-8d17134ee686 Veyrat-Durebex, C. (Christelle)\|\|\|/items/9d98726e-c438-4ce5-8934-f502d9067ba2 Seoane, S. (Samuel)\|\|\|/items/04b32e0a-25e4-447c-b714-db1895887045 Bernardo, G. (Ganeko)\|\|\|/items/5ef92288-af4e-4e5a-b1d0-ce00708cc8bd Lopitz-Otsoa, F. (Fernando)\|\|\|/items/5e18ab21-ac81-4254-ae11-9dc9d3213e80 Fernández-Ramos, D. (David)\|\|\|/items/d5e19220-54fe-4552-ad3a-5bb8150cd786 Bilbao, J. (Jon)\|\|\|/items/d558ad14-d0b1-4ff0-aa00-e36ee854dac5 Iglesias, C. (Cristina)\|\|\|/items/6c293a8c-e822-45bd-a55f-19dd42bf8d05 Novoa, E. (Eva)\|\|\|/items/766fd1b8-02a2-455c-9709-c565201be738 Ameneiro, C. (Cristina)\|\|\|/items/a8899de9-19dd-41f5-ba90-2571cbdd9584 Senra, A. (Ana)\|\|\|/items/f48cb1cd-d1eb-46d4-abc6-c985f6e23cc4 Beiroa, D. (Daniel)\|\|\|/items/59b676a1-cbf0-4dd2-9e87-f0fe518e14c6 Cuñarro, J. (Juan)\|\|\|/items/4f31a7ee-5d63-48a5-8589-937b1e064278 Chantada-Vazquez, M.D.P. (Maria D.P.)\|\|\|/items/ff0d8bb2-d9b0-489c-9d52-bd1a40b63be9 Garcia-Vence, M. (Maria)\|\|\|/items/fd3ba38b-869c-4687-a7a7-f3399700e5eb Bravo, S. (Susana B.)\|\|\|/items/e01e519b-f836-4fcb-86d7-31112734e8e2 da-Silva-Lima, N. (Natalia)\|\|\|/items/9e088f99-dea7-42cf-8026-21c1027c1af8 Porteiro, B. (Begoña)\|\|\|/items/a0469e98-1bfb-4768-ada9-24573be6f1cb Carneiro, C. (Carmen)\|\|\|/items/5705da5b-e5cb-48ec-9ec5-746f1fe2c0ec Vidal, A. (Anxo)\|\|\|/items/a8facbdb-e501-4b94-9e61-fa3244770258 Tovar, S. (Sulay)\|\|\|/items/5716a149-8ad6-45d3-b30b-4f67d30cd2fb Müller, T.D. (Timo D.)\|\|\|/items/e61aad48-a7c8-45a7-b479-6358a9659fa6 Ferno, J. (Johan)\|\|\|/items/6babd121-81a7-41ca-8d0c-edbea833d10b Guallar, D. (Diana)\|\|\|/items/1dc9d5a7-af90-4a94-86a4-9e3e6b3d4058 Fidalgo, M. (Miguel)\|\|\|/items/35c79a24-3ecd-498b-bc11-3a43ce977d46 Sabio, G. (Guadalupe)\|\|\|/items/f04ae0a3-ab59-4e44-b814-5e413bd5584d Herzig, S. (Stephan)\|\|\|/items/386d0e63-7570-43c0-8777-8098a62b5396 Yang, W.H. (Won Ho)\|\|\|/items/77c8f762-1c9c-4381-ab12-c79d2e8e209f Cho, J.W. (Jin Won)\|\|\|/items/32b24e5d-69d2-4de8-821d-139899127fbe Martinez-Chantar, M.L. (María Luz)\|\|\|/items/df06120b-2a53-4074-a155-638f899b2ce5 Perez-Fernandez, R. (Roman)\|\|\|/items/91f47f3e-1252-4e50-8446-0da3888e794d López-Yoldi, M. (Miguel)\|\|\|/items/d3db8959-5c7f-4257-8a0a-b2374e5da832 Dieguez, C. (Carlos)\|\|\|/items/54b49b82-82ec-4bb6-9d48-c54fb1d572fb Mato, J.M. (José María)\|\|\|/items/302dc624-b0d3-4703-90cf-1a97690ebc79 Millet, O. (Oscar)\|\|\|/items/d6bbd577-a3c4-4f18-9dc5-1686de0e0489 Coppari, R. (Roberto)\|\|\|/items/0aab48ad-95e3-4a9b-aead-c2edc24d5433 Woodhoo, A. (Ashwin)\|\|\|/items/a9e90cb2-bac1-43fb-a0b2-5e3409f9c860 Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Nogueiras, R. (Rubén)\|\|\|/items/d6d4c851-6ed5-47d3-9361-c80bbfae88e6
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	P53 Metabolic homeostasis of cells Response to stress
topic	P53 Metabolic homeostasis of cells Response to stress
description	p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could be linked to glucose maintenance. We show here that upon starvation hepatic p53 is stabilized by O-GlcNAcylation and plays an essential role in the physiological regulation of glucose homeostasis. More specifically, p53 binds to PCK1 promoter and regulates its transcriptional activation, thereby controlling hepatic glucose production. Mice lacking p53 in the liver show a reduced gluconeogenic response during calorie restriction. Glucagon, adrenaline and glucocorticoids augment protein levels of p53, and administration of these hormones to p53 deficient human hepatocytes and to liver-specific p53 deficient mice fails to increase glucose levels. Moreover, insulin decreases p53 levels, and over-expression of p53 impairs insulin sensitivity. Finally, protein levels of p53, as well as genes responsible of O-GlcNAcylation are elevated in the liver of type 2 diabetic patients and positively correlate with glucose and HOMA-IR. Overall these results indicate that the O-GlcNAcylation of p53 plays an unsuspected key role regulating in vivo glucose homeostasis.
publishDate	2021
dc.date.none.fl_str_mv	2021 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/114713
url	https://hdl.handle.net/10171/114713
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Nature Pub. Group
publisher.none.fl_str_mv	Nature Pub. Group
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869405127564066817
spelling	O-GlcNAcylated p53 in the liver modulates hepatic glucose productionGonzalez-Rellan, M.J. (María J.)\|\|\|/items/eb5f3b93-72d6-4030-b4f0-feb2293ebe75Fondevila, M.F. (Marcos F.)\|\|\|/items/42515fd5-cb1f-44a3-99aa-b643d79de50bFernández, U. (Uxía)\|\|\|/items/b5339a5a-3803-4411-b618-ee1c94654657Rodriguez, A. (Amaia)\|\|\|/items/50976a5f-9842-47f1-8a9c-508e59996427Varela-Rey, M. (Marta)\|\|\|/items/c142211c-bbe7-4b40-a3ad-8d17134ee686Veyrat-Durebex, C. (Christelle)\|\|\|/items/9d98726e-c438-4ce5-8934-f502d9067ba2Seoane, S. (Samuel)\|\|\|/items/04b32e0a-25e4-447c-b714-db1895887045Bernardo, G. (Ganeko)\|\|\|/items/5ef92288-af4e-4e5a-b1d0-ce00708cc8bdLopitz-Otsoa, F. (Fernando)\|\|\|/items/5e18ab21-ac81-4254-ae11-9dc9d3213e80Fernández-Ramos, D. (David)\|\|\|/items/d5e19220-54fe-4552-ad3a-5bb8150cd786Bilbao, J. (Jon)\|\|\|/items/d558ad14-d0b1-4ff0-aa00-e36ee854dac5Iglesias, C. (Cristina)\|\|\|/items/6c293a8c-e822-45bd-a55f-19dd42bf8d05Novoa, E. (Eva)\|\|\|/items/766fd1b8-02a2-455c-9709-c565201be738Ameneiro, C. (Cristina)\|\|\|/items/a8899de9-19dd-41f5-ba90-2571cbdd9584Senra, A. (Ana)\|\|\|/items/f48cb1cd-d1eb-46d4-abc6-c985f6e23cc4Beiroa, D. (Daniel)\|\|\|/items/59b676a1-cbf0-4dd2-9e87-f0fe518e14c6Cuñarro, J. (Juan)\|\|\|/items/4f31a7ee-5d63-48a5-8589-937b1e064278Chantada-Vazquez, M.D.P. (Maria D.P.)\|\|\|/items/ff0d8bb2-d9b0-489c-9d52-bd1a40b63be9Garcia-Vence, M. (Maria)\|\|\|/items/fd3ba38b-869c-4687-a7a7-f3399700e5ebBravo, S. (Susana B.)\|\|\|/items/e01e519b-f836-4fcb-86d7-31112734e8e2da-Silva-Lima, N. (Natalia)\|\|\|/items/9e088f99-dea7-42cf-8026-21c1027c1af8Porteiro, B. (Begoña)\|\|\|/items/a0469e98-1bfb-4768-ada9-24573be6f1cbCarneiro, C. (Carmen)\|\|\|/items/5705da5b-e5cb-48ec-9ec5-746f1fe2c0ecVidal, A. (Anxo)\|\|\|/items/a8facbdb-e501-4b94-9e61-fa3244770258Tovar, S. (Sulay)\|\|\|/items/5716a149-8ad6-45d3-b30b-4f67d30cd2fbMüller, T.D. (Timo D.)\|\|\|/items/e61aad48-a7c8-45a7-b479-6358a9659fa6Ferno, J. (Johan)\|\|\|/items/6babd121-81a7-41ca-8d0c-edbea833d10bGuallar, D. (Diana)\|\|\|/items/1dc9d5a7-af90-4a94-86a4-9e3e6b3d4058Fidalgo, M. (Miguel)\|\|\|/items/35c79a24-3ecd-498b-bc11-3a43ce977d46Sabio, G. (Guadalupe)\|\|\|/items/f04ae0a3-ab59-4e44-b814-5e413bd5584dHerzig, S. (Stephan)\|\|\|/items/386d0e63-7570-43c0-8777-8098a62b5396Yang, W.H. (Won Ho)\|\|\|/items/77c8f762-1c9c-4381-ab12-c79d2e8e209fCho, J.W. (Jin Won)\|\|\|/items/32b24e5d-69d2-4de8-821d-139899127fbeMartinez-Chantar, M.L. (María Luz)\|\|\|/items/df06120b-2a53-4074-a155-638f899b2ce5Perez-Fernandez, R. (Roman)\|\|\|/items/91f47f3e-1252-4e50-8446-0da3888e794dLópez-Yoldi, M. (Miguel)\|\|\|/items/d3db8959-5c7f-4257-8a0a-b2374e5da832Dieguez, C. (Carlos)\|\|\|/items/54b49b82-82ec-4bb6-9d48-c54fb1d572fbMato, J.M. (José María)\|\|\|/items/302dc624-b0d3-4703-90cf-1a97690ebc79Millet, O. (Oscar)\|\|\|/items/d6bbd577-a3c4-4f18-9dc5-1686de0e0489Coppari, R. (Roberto)\|\|\|/items/0aab48ad-95e3-4a9b-aead-c2edc24d5433Woodhoo, A. (Ashwin)\|\|\|/items/a9e90cb2-bac1-43fb-a0b2-5e3409f9c860Frühbeck, G. (Gema)\|\|\|/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663bNogueiras, R. (Rubén)\|\|\|/items/d6d4c851-6ed5-47d3-9361-c80bbfae88e6P53Metabolic homeostasis of cellsResponse to stressp53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we hypothesized that p53 could be linked to glucose maintenance. We show here that upon starvation hepatic p53 is stabilized by O-GlcNAcylation and plays an essential role in the physiological regulation of glucose homeostasis. More specifically, p53 binds to PCK1 promoter and regulates its transcriptional activation, thereby controlling hepatic glucose production. Mice lacking p53 in the liver show a reduced gluconeogenic response during calorie restriction. Glucagon, adrenaline and glucocorticoids augment protein levels of p53, and administration of these hormones to p53 deficient human hepatocytes and to liver-specific p53 deficient mice fails to increase glucose levels. Moreover, insulin decreases p53 levels, and over-expression of p53 impairs insulin sensitivity. Finally, protein levels of p53, as well as genes responsible of O-GlcNAcylation are elevated in the liver of type 2 diabetic patients and positively correlate with glucose and HOMA-IR. Overall these results indicate that the O-GlcNAcylation of p53 plays an unsuspected key role regulating in vivo glucose homeostasis.Nature Pub. GroupDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/114713reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1147132026-06-21T12:47:57Z
score	15.812429

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Similares en LA Referencia