A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves

17 pages, 7 figures.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

Detalles Bibliográficos
Autores: Saco, Amaro, Suárez, Hugo, Novoa, Beatriz, Figueras Huerta, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/308121
Acceso en línea:http://hdl.handle.net/10261/308121
Access Level:acceso abierto
Palabra clave:C-type lectins
Lectins
Bivalves
Innate immunity
Evolution
Component system
Mollusca
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spelling A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in BivalvesSaco, AmaroSuárez, HugoNovoa, BeatrizFigueras Huerta, AntonioC-type lectinsLectinsBivalvesInnate immunityEvolutionComponent systemMollusca17 pages, 7 figures.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseC-type lectins belong to a widely conserved family of lectins characterized in Metazoa. They show important functional diversity and immune implications, mainly as pathogen recognition receptors. In this work, C-type lectin-like proteins (CTLs) of a set of metazoan species were analyzed, revealing an important expansion in bivalve mollusks, which contrasted with the reduced repertoires of other mollusks, such as cephalopods. Orthology relationships demonstrated that these expanded repertoires consisted of CTL subfamilies conserved within Mollusca or Bivalvia and of lineage-specific subfamilies with orthology only between closely related species. Transcriptomic analyses revealed the importance of the bivalve subfamilies in mucosal immunity, as they were mainly expressed in the digestive gland and gills and modulated with specific stimuli. CTL domain-containing proteins that had additional domains (CTLDcps) were also studied, revealing interesting gene families with different conservation degrees of the CTL domain across orthologs from different taxa. Unique bivalve CTLDcps with specific domain architectures were revealed, corresponding to uncharacterized bivalve proteins with putative immune function according to their transcriptomic modulation, which could constitute interesting targets for functional characterization.This research was funded by the Ministerio de Ciencia e Innovación (PID2021-124955OB-I00) and Xunta de Galicia (IN607B 2022/13). A.S. was supported by a Spanish AEI/EU-FSE predoctoral contract PRE2019-090760.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Xunta de GaliciaMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/308121reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//PID2021-124955OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095997-B-I00The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.3390/md21040254https://doi.org/10.3390/md21040254Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3081212026-05-22T06:33:51Z
dc.title.none.fl_str_mv A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
title A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
spellingShingle A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
Saco, Amaro
C-type lectins
Lectins
Bivalves
Innate immunity
Evolution
Component system
Mollusca
title_short A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
title_full A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
title_fullStr A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
title_full_unstemmed A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
title_sort A Genomic and Transcriptomic Analysis of the C-Type Lectin Gene Family Reveals Highly Expanded and Diversified Repertoires in Bivalves
dc.creator.none.fl_str_mv Saco, Amaro
Suárez, Hugo
Novoa, Beatriz
Figueras Huerta, Antonio
author Saco, Amaro
author_facet Saco, Amaro
Suárez, Hugo
Novoa, Beatriz
Figueras Huerta, Antonio
author_role author
author2 Suárez, Hugo
Novoa, Beatriz
Figueras Huerta, Antonio
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Xunta de Galicia
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv C-type lectins
Lectins
Bivalves
Innate immunity
Evolution
Component system
Mollusca
topic C-type lectins
Lectins
Bivalves
Innate immunity
Evolution
Component system
Mollusca
description 17 pages, 7 figures.-- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/308121
url http://hdl.handle.net/10261/308121
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//PID2021-124955OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095997-B-I00
The underlying dataset has been published as supplementary material of the article in the publishers platform at DOI https://doi.org/10.3390/md21040254
https://doi.org/10.3390/md21040254
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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