Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study
The potential protective effect of renin?angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2165 cases of colorectal cancer,...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/12904 |
| Acceso en línea: | http://hdl.handle.net/10902/12904 |
| Access Level: | acceso abierto |
| Palabra clave: | Colorectal cancer Angiotensin converting enzyme inhibitor Angiotensin receptor blocker |
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España |
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| dc.title.none.fl_str_mv |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| title |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| spellingShingle |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study Dierssen Sotos, Trinidad Colorectal cancer Angiotensin converting enzyme inhibitor Angiotensin receptor blocker |
| title_short |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| title_full |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| title_fullStr |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| title_full_unstemmed |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| title_sort |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study |
| dc.creator.none.fl_str_mv |
Dierssen Sotos, Trinidad Gómez Acebo, Inés Palazuelos Calderón, Camilo Rodriguez Moranta, Francisco Pérez Gómez, Beatriz Fernández Vazquez, José Pedro Amiano, Pilar Barricarte, Aurelio Mirón Pozo, Benito Tardón García, Adonina Capelo, Rocío Peiró Pérez, Rosana Huerta, José María Andreu, Montserrat Sierra, María Ángeles Castañón López, Carmen Ruiz, Irune Moreno Iribas, Concepción Olmedo Requena, Rocío Llorca Díaz, Francisco Javier|||0000-0001-8569-861X |
| author |
Dierssen Sotos, Trinidad |
| author_facet |
Dierssen Sotos, Trinidad Gómez Acebo, Inés Palazuelos Calderón, Camilo Rodriguez Moranta, Francisco Pérez Gómez, Beatriz Fernández Vazquez, José Pedro Amiano, Pilar Barricarte, Aurelio Mirón Pozo, Benito Tardón García, Adonina Capelo, Rocío Peiró Pérez, Rosana Huerta, José María Andreu, Montserrat Sierra, María Ángeles Castañón López, Carmen Ruiz, Irune Moreno Iribas, Concepción Olmedo Requena, Rocío Llorca Díaz, Francisco Javier|||0000-0001-8569-861X |
| author_role |
author |
| author2 |
Gómez Acebo, Inés Palazuelos Calderón, Camilo Rodriguez Moranta, Francisco Pérez Gómez, Beatriz Fernández Vazquez, José Pedro Amiano, Pilar Barricarte, Aurelio Mirón Pozo, Benito Tardón García, Adonina Capelo, Rocío Peiró Pérez, Rosana Huerta, José María Andreu, Montserrat Sierra, María Ángeles Castañón López, Carmen Ruiz, Irune Moreno Iribas, Concepción Olmedo Requena, Rocío Llorca Díaz, Francisco Javier|||0000-0001-8569-861X |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Colorectal cancer Angiotensin converting enzyme inhibitor Angiotensin receptor blocker |
| topic |
Colorectal cancer Angiotensin converting enzyme inhibitor Angiotensin receptor blocker |
| description |
The potential protective effect of renin?angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2165 cases of colorectal cancer, diagnosed between 2007 and 2012, and 3912 population controls frequency matched (by age, sex and region) fromthe Spanishmulticenter case-control studyMCCSpain. We found a significant protective effect of the angiotensin-converting enzyme Inhibitors (ACEIs) against CRC, limited to the under-65 years group (OR=0.65 95%CI (0.48?0.89)) and to a lesser degree tomen (OR=0.81 95%CI (0.66?0.99). In contrast, the angiotensin receptor blockers (ARBs) did not show a significant effect. Regarding the duration of use, a greater protection was observed in men as the length of consumption increases. In contrast, in the under-65 stratum, the strongest association was found in short-term treatments. Finally, by analyzing ACEIs effect by colon subsite, we found no differences, except for under 65 years old, where the maximum protection was seen in the proximal intestine, descending in the distal and rectum (without statistical significance). In conclusion, our study shows a protective effect on CRC of the ACEis limited to males and people under 65 years old, which increases in proximal colon in the latter. If confirmed, these resultsmay suggest a novel approach to proximal CRC prevention, given the shortcomings of colonoscopy screening in this location. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-06-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10902/12904 |
| url |
http://hdl.handle.net/10902/12904 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Prev Med. 2017 Jun;99:178-184 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
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Universidad de Cantabria (UC) |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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1869405111017537536 |
| spelling |
Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain studyDierssen Sotos, TrinidadGómez Acebo, InésPalazuelos Calderón, CamiloRodriguez Moranta, FranciscoPérez Gómez, BeatrizFernández Vazquez, José PedroAmiano, PilarBarricarte, AurelioMirón Pozo, BenitoTardón García, AdoninaCapelo, RocíoPeiró Pérez, RosanaHuerta, José MaríaAndreu, MontserratSierra, María ÁngelesCastañón López, CarmenRuiz, IruneMoreno Iribas, ConcepciónOlmedo Requena, RocíoLlorca Díaz, Francisco Javier|||0000-0001-8569-861XColorectal cancerAngiotensin converting enzyme inhibitorAngiotensin receptor blockerThe potential protective effect of renin?angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2165 cases of colorectal cancer, diagnosed between 2007 and 2012, and 3912 population controls frequency matched (by age, sex and region) fromthe Spanishmulticenter case-control studyMCCSpain. We found a significant protective effect of the angiotensin-converting enzyme Inhibitors (ACEIs) against CRC, limited to the under-65 years group (OR=0.65 95%CI (0.48?0.89)) and to a lesser degree tomen (OR=0.81 95%CI (0.66?0.99). In contrast, the angiotensin receptor blockers (ARBs) did not show a significant effect. Regarding the duration of use, a greater protection was observed in men as the length of consumption increases. In contrast, in the under-65 stratum, the strongest association was found in short-term treatments. Finally, by analyzing ACEIs effect by colon subsite, we found no differences, except for under 65 years old, where the maximum protection was seen in the proximal intestine, descending in the distal and rectum (without statistical significance). In conclusion, our study shows a protective effect on CRC of the ACEis limited to males and people under 65 years old, which increases in proximal colon in the latter. If confirmed, these resultsmay suggest a novel approach to proximal CRC prevention, given the shortcomings of colonoscopy screening in this location.This work was supported by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613), PI15/00069, PI15/01032, PI15/00914, by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government DURSI grant 2014SGR647, by the Fundación Caja de Ahorros de Asturias and by the University of Oviedo.ElsevierUniversidad de Cantabria20172017-06-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/12904Prev Med. 2017 Jun;99:178-184reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/129042026-06-02T12:39:31Z |
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15,300719 |