Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.

Background: Previous studies have presented contradictory data concerning obstructive sleep apnoea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability. This study was undertaken to (1) compare the concentration of 8-isoprostane and total nitrate and nitrite (NOx) in plasma of midd...

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Autores: Alonso-Fernández, A., García Río, Francisco, Arias, Miguel Ángel, Hernanz, Á., Peña, Mónica de la, Piérola, Javier, Barceló, Antonia, López Collazo, Eduardo, Agustí García-Navarro, Àlvar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/34971
Acceso en línea:https://hdl.handle.net/2445/34971
Access Level:acceso abierto
Palabra clave:Òxid nítric
Síndromes d'apnea del son
Estrès oxidatiu
Nitric oxide
Sleep apnea syndromes
Oxidative stress
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spelling Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.Alonso-Fernández, A.García Río, FranciscoArias, Miguel ÁngelHernanz, Á.Peña, Mónica de laPiérola, JavierBarceló, AntoniaLópez Collazo, EduardoAgustí García-Navarro, ÀlvarÒxid nítricSíndromes d'apnea del sonEstrès oxidatiuNitric oxideSleep apnea syndromesOxidative stressBackground: Previous studies have presented contradictory data concerning obstructive sleep apnoea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability. This study was undertaken to (1) compare the concentration of 8-isoprostane and total nitrate and nitrite (NOx) in plasma of middle-aged men with OSAS and no other known co-morbidity and healthy controls of the same age, gender and body mass index; and (2) test the hypothesis that nasal continuous positive airway pressure (CPAP) therapy attenuates oxidative stress and nitrate deficiency. Methods: A prospective, randomised, placebo controlled, double-blind, crossover study was performed in 31 consecutive middle-aged men with newly diagnosed OSAS and 15 healthy control subjects. Patients with OSAS were randomised to receive sham CPAP or effective CPAP for 12 weeks. Blood pressure, urinary catecholamine levels and plasma 8-isoprostane and NOx concentrations were obtained before and after both treatment modalities. Results: Patients with OSAS had significantly higher 8-isoprostane levels (median (IQR) 42.5 (29.2-78.2) vs 20.0 (12.5-52.5) pg/ml, p = 0.041, Mann-Whitney test) and lower NOx levels (264 (165-650) vs 590 (251- 1465) mmol/l, p = 0.022) than healthy subjects. Body mass index, blood pressure and urinary catecholamines were unchanged by CPAP therapy, but 8-isoprostane concentrations decreased (38.5 (24.2-58.7) pg/ml at baseline vs 22.5 (16.2-35.3) pg/ml on CPAP, p = 0.0001) and NOx levels increased (280 (177-707) vs 1373 (981-1517) mmol/l, p = 0.0001) after CPAP. Conclusions: OSAS is associated with an increase in oxidative stress and a decrease in NOx that is normalisedBMJ Publishing Group2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/34971Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1136/thx.2008.100537Thorax, 2008, vol. 64, num. 7, p. 581-586http://dx.doi.org/10.1136/thx.2008.100537(c) BMJ Publishing Group, 2008info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/349712026-05-27T06:46:51Z
dc.title.none.fl_str_mv Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
title Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
spellingShingle Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
Alonso-Fernández, A.
Òxid nítric
Síndromes d'apnea del son
Estrès oxidatiu
Nitric oxide
Sleep apnea syndromes
Oxidative stress
title_short Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
title_full Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
title_fullStr Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
title_full_unstemmed Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
title_sort Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial.
dc.creator.none.fl_str_mv Alonso-Fernández, A.
García Río, Francisco
Arias, Miguel Ángel
Hernanz, Á.
Peña, Mónica de la
Piérola, Javier
Barceló, Antonia
López Collazo, Eduardo
Agustí García-Navarro, Àlvar
author Alonso-Fernández, A.
author_facet Alonso-Fernández, A.
García Río, Francisco
Arias, Miguel Ángel
Hernanz, Á.
Peña, Mónica de la
Piérola, Javier
Barceló, Antonia
López Collazo, Eduardo
Agustí García-Navarro, Àlvar
author_role author
author2 García Río, Francisco
Arias, Miguel Ángel
Hernanz, Á.
Peña, Mónica de la
Piérola, Javier
Barceló, Antonia
López Collazo, Eduardo
Agustí García-Navarro, Àlvar
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Òxid nítric
Síndromes d'apnea del son
Estrès oxidatiu
Nitric oxide
Sleep apnea syndromes
Oxidative stress
topic Òxid nítric
Síndromes d'apnea del son
Estrès oxidatiu
Nitric oxide
Sleep apnea syndromes
Oxidative stress
description Background: Previous studies have presented contradictory data concerning obstructive sleep apnoea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability. This study was undertaken to (1) compare the concentration of 8-isoprostane and total nitrate and nitrite (NOx) in plasma of middle-aged men with OSAS and no other known co-morbidity and healthy controls of the same age, gender and body mass index; and (2) test the hypothesis that nasal continuous positive airway pressure (CPAP) therapy attenuates oxidative stress and nitrate deficiency. Methods: A prospective, randomised, placebo controlled, double-blind, crossover study was performed in 31 consecutive middle-aged men with newly diagnosed OSAS and 15 healthy control subjects. Patients with OSAS were randomised to receive sham CPAP or effective CPAP for 12 weeks. Blood pressure, urinary catecholamine levels and plasma 8-isoprostane and NOx concentrations were obtained before and after both treatment modalities. Results: Patients with OSAS had significantly higher 8-isoprostane levels (median (IQR) 42.5 (29.2-78.2) vs 20.0 (12.5-52.5) pg/ml, p = 0.041, Mann-Whitney test) and lower NOx levels (264 (165-650) vs 590 (251- 1465) mmol/l, p = 0.022) than healthy subjects. Body mass index, blood pressure and urinary catecholamines were unchanged by CPAP therapy, but 8-isoprostane concentrations decreased (38.5 (24.2-58.7) pg/ml at baseline vs 22.5 (16.2-35.3) pg/ml on CPAP, p = 0.0001) and NOx levels increased (280 (177-707) vs 1373 (981-1517) mmol/l, p = 0.0001) after CPAP. Conclusions: OSAS is associated with an increase in oxidative stress and a decrease in NOx that is normalised
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/34971
url https://hdl.handle.net/2445/34971
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1136/thx.2008.100537
Thorax, 2008, vol. 64, num. 7, p. 581-586
http://dx.doi.org/10.1136/thx.2008.100537
dc.rights.none.fl_str_mv (c) BMJ Publishing Group, 2008
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group, 2008
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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