Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players
Many causes define injuries in professional soccer players. In recent years, the study of genetics in association with injuries has been of great interest. The purpose of this study was to examine the relationship between muscle injury-related genes, injury risk and injury etiology in professional s...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/124455 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/124455 |
| Access Level: | acceso abierto |
| Palabra clave: | 612 796:61 616.74 612.74 575 Muscle performance Single nucleotide polymorphism Genes, Injuries Muscle injuries Epidemiology Football (soccer) Medicina del deporte Fisiología Sistema musculoesquelético Genética 2411 Fisiología Humana 2411.10 Fisiología del Músculo 2411.06 Fisiología del Ejercicio 2410.07 Genética Humana |
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Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer playersMaestro, AntonioDel Coso, JuanAguilar Navarro, MillánGutiérrez Hellín, JorgeMorencos, EstherRevuelta, GonzaloRuiz Casares, EvaPerucho Alcalde, TeresaVarillas Delgado, David612796:61616.74612.74575Muscle performanceSingle nucleotide polymorphismGenes, InjuriesMuscle injuriesEpidemiologyFootball (soccer)Medicina del deporteFisiologíaSistema musculoesqueléticoGenética2411 Fisiología Humana2411.10 Fisiología del Músculo2411.06 Fisiología del Ejercicio2410.07 Genética HumanaMany causes define injuries in professional soccer players. In recent years, the study of genetics in association with injuries has been of great interest. The purpose of this study was to examine the relationship between muscle injury-related genes, injury risk and injury etiology in professional soccer players. In a cross-sectional cohort study, one hundred and twenty-two male professional football players were recruited. AMPD1 (rs17602729), ACE (rs4646994), ACTN3 (rs1815739), CKM (rs8111989) and MLCK (rs2849757 and rs2700352) polymorphisms were genotyped by using Single Nucleotide Primer Extension (SNPE). The combined influence of the six polymorphisms studied was calculated using a total genotype score (TGS). A genotype score (GS) of 2 was assigned to the “protective” genotype for injuries, a GS of 1 was assigned to the heterozygous genotype while a GS of 0 was assigned to the “worst” genotype. Injury characteristics and etiology during the 2021/2022 season were classified following a Consensus Statement for injuries recording. The distribution of allelic frequencies in the AMPD1 and MLCK c.37885C>A polymorphisms were different between non-injured and injured soccer players (p < 0.001 and p = 0.003, respectively). The mean total genotype score (TGS) in non-injured soccer players (57.18 ± 14.43 arbitrary units [a.u.]) was different from that of injured soccer players (51.71 ± 12.82 a.u., p = 0.034). There was a TGS cut-off point (45.83 a.u.) to discriminate non-injured from injured soccer players. Players with a TGS beyond this cut-off had an odds ratio of 1.91 (95%CI: 1.14–2.91; p = 0.022) to suffer an injury when compared with players with lower TGS. In conclusion, TGS analysis in muscle injury-related genes presented a relationship with professional soccer players at increased risk of injury. Future studies will help to develop this TGS as a potential tool to predict injury risk and perform prevention methodology in this cohort of football players.Frontiers MediaUniversidad Complutense de Madrid20222022-11-1620222022-11-16journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/124455reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1244552026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| title |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| spellingShingle |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players Maestro, Antonio 612 796:61 616.74 612.74 575 Muscle performance Single nucleotide polymorphism Genes, Injuries Muscle injuries Epidemiology Football (soccer) Medicina del deporte Fisiología Sistema musculoesquelético Genética 2411 Fisiología Humana 2411.10 Fisiología del Músculo 2411.06 Fisiología del Ejercicio 2410.07 Genética Humana |
| title_short |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| title_full |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| title_fullStr |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| title_full_unstemmed |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| title_sort |
Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players |
| dc.creator.none.fl_str_mv |
Maestro, Antonio Del Coso, Juan Aguilar Navarro, Millán Gutiérrez Hellín, Jorge Morencos, Esther Revuelta, Gonzalo Ruiz Casares, Eva Perucho Alcalde, Teresa Varillas Delgado, David |
| author |
Maestro, Antonio |
| author_facet |
Maestro, Antonio Del Coso, Juan Aguilar Navarro, Millán Gutiérrez Hellín, Jorge Morencos, Esther Revuelta, Gonzalo Ruiz Casares, Eva Perucho Alcalde, Teresa Varillas Delgado, David |
| author_role |
author |
| author2 |
Del Coso, Juan Aguilar Navarro, Millán Gutiérrez Hellín, Jorge Morencos, Esther Revuelta, Gonzalo Ruiz Casares, Eva Perucho Alcalde, Teresa Varillas Delgado, David |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
612 796:61 616.74 612.74 575 Muscle performance Single nucleotide polymorphism Genes, Injuries Muscle injuries Epidemiology Football (soccer) Medicina del deporte Fisiología Sistema musculoesquelético Genética 2411 Fisiología Humana 2411.10 Fisiología del Músculo 2411.06 Fisiología del Ejercicio 2410.07 Genética Humana |
| topic |
612 796:61 616.74 612.74 575 Muscle performance Single nucleotide polymorphism Genes, Injuries Muscle injuries Epidemiology Football (soccer) Medicina del deporte Fisiología Sistema musculoesquelético Genética 2411 Fisiología Humana 2411.10 Fisiología del Músculo 2411.06 Fisiología del Ejercicio 2410.07 Genética Humana |
| description |
Many causes define injuries in professional soccer players. In recent years, the study of genetics in association with injuries has been of great interest. The purpose of this study was to examine the relationship between muscle injury-related genes, injury risk and injury etiology in professional soccer players. In a cross-sectional cohort study, one hundred and twenty-two male professional football players were recruited. AMPD1 (rs17602729), ACE (rs4646994), ACTN3 (rs1815739), CKM (rs8111989) and MLCK (rs2849757 and rs2700352) polymorphisms were genotyped by using Single Nucleotide Primer Extension (SNPE). The combined influence of the six polymorphisms studied was calculated using a total genotype score (TGS). A genotype score (GS) of 2 was assigned to the “protective” genotype for injuries, a GS of 1 was assigned to the heterozygous genotype while a GS of 0 was assigned to the “worst” genotype. Injury characteristics and etiology during the 2021/2022 season were classified following a Consensus Statement for injuries recording. The distribution of allelic frequencies in the AMPD1 and MLCK c.37885C>A polymorphisms were different between non-injured and injured soccer players (p < 0.001 and p = 0.003, respectively). The mean total genotype score (TGS) in non-injured soccer players (57.18 ± 14.43 arbitrary units [a.u.]) was different from that of injured soccer players (51.71 ± 12.82 a.u., p = 0.034). There was a TGS cut-off point (45.83 a.u.) to discriminate non-injured from injured soccer players. Players with a TGS beyond this cut-off had an odds ratio of 1.91 (95%CI: 1.14–2.91; p = 0.022) to suffer an injury when compared with players with lower TGS. In conclusion, TGS analysis in muscle injury-related genes presented a relationship with professional soccer players at increased risk of injury. Future studies will help to develop this TGS as a potential tool to predict injury risk and perform prevention methodology in this cohort of football players. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-11-16 2022 2022-11-16 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/124455 |
| url |
https://hdl.handle.net/20.500.14352/124455 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
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Frontiers Media |
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reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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15.812429 |