Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma
This article belongs to the Special Issue Advances in Multiple Myeloma Research and Treatment.
| Autores: | , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/262057 |
| Acceso en línea: | http://hdl.handle.net/10261/262057 |
| Access Level: | acceso abierto |
| Palabra clave: | Multiple myeloma Minimal residual disease Hemodilution |
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Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| title |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| spellingShingle |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma Puig, Noemi Multiple myeloma Minimal residual disease Hemodilution |
| title_short |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| title_full |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| title_fullStr |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| title_full_unstemmed |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| title_sort |
Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma |
| dc.creator.none.fl_str_mv |
Puig, Noemi Flores-Montero, Juan Burgos, Leire Cedena, Maria-Teresa Cordón, Lourdes Pérez, José J. Sanoja-Flores, Luzalba Manrique, Irene Rodríguez-Otero, Paula Rosiñol, Laura Martínez-López, Joaquín Mateos, Maria Victoria Lahuerta, Juan José Bladé, Joan San Miguel, Jesús F. Orfao, Alberto Paiva, Bruno |
| author |
Puig, Noemi |
| author_facet |
Puig, Noemi Flores-Montero, Juan Burgos, Leire Cedena, Maria-Teresa Cordón, Lourdes Pérez, José J. Sanoja-Flores, Luzalba Manrique, Irene Rodríguez-Otero, Paula Rosiñol, Laura Martínez-López, Joaquín Mateos, Maria Victoria Lahuerta, Juan José Bladé, Joan San Miguel, Jesús F. Orfao, Alberto Paiva, Bruno |
| author_role |
author |
| author2 |
Flores-Montero, Juan Burgos, Leire Cedena, Maria-Teresa Cordón, Lourdes Pérez, José J. Sanoja-Flores, Luzalba Manrique, Irene Rodríguez-Otero, Paula Rosiñol, Laura Martínez-López, Joaquín Mateos, Maria Victoria Lahuerta, Juan José Bladé, Joan San Miguel, Jesús F. Orfao, Alberto Paiva, Bruno |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Investigación Biomédica en Red Cáncer (España) Instituto de Salud Carlos III European Commission Cancer Research UK Fundación Científica Asociación Española Contra el Cáncer Associazione Italiana per la Ricerca sul Cancro International Myeloma Foundation European Research Council Paula and Rodger Riney Foundation Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Multiple myeloma Minimal residual disease Hemodilution |
| topic |
Multiple myeloma Minimal residual disease Hemodilution |
| description |
This article belongs to the Special Issue Advances in Multiple Myeloma Research and Treatment. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 2022 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/262057 |
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http://hdl.handle.net/10261/262057 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/680200 http://dx.doi.org/10.3390/cancers13194924 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869405097993175040 |
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Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in MyelomaPuig, NoemiFlores-Montero, JuanBurgos, LeireCedena, Maria-TeresaCordón, LourdesPérez, José J.Sanoja-Flores, LuzalbaManrique, IreneRodríguez-Otero, PaulaRosiñol, LauraMartínez-López, JoaquínMateos, Maria VictoriaLahuerta, Juan JoséBladé, JoanSan Miguel, Jesús F.Orfao, AlbertoPaiva, BrunoMultiple myelomaMinimal residual diseaseHemodilutionThis article belongs to the Special Issue Advances in Multiple Myeloma Research and Treatment.[Simple Summary] Although the majority of patients with myeloma who achieve undetectable minimal residual disease show prolonged survival, some of them relapse shortly afterwards. False-negative results due to hemodiluted bone marrow samples could explain this inconsistency, but there is no guidance on how to evaluate them. We analyzed three cell populations normally absent in peripheral blood in 1404 aspirates obtained in numerous disease settings and in 85 healthy adults. Pairwise comparisons according to age and treatment showed significant variability, thus suggesting that hemodilution should be preferably evaluated with references obtained after receiving identical regimens. Leveraging the minimal residual disease results from 118 patients, we showed that a comparison with age-matched healthy adults could also inform on potential hemodilution. Our study supports the routine assessment of bone marrow cellularity to evaluate hemodilution, using as reference values either treatment-specific or from healthy adults if the former are unavailable.[Abstract] Background: Whereas, in most patients with multiple myeloma (MM), achieving undetectable MRD anticipates a favorable outcome, some others relapse shortly afterwards. Although one obvious explanation for this inconsistency is the use of nonrepresentative marrow samples due to hemodilution, there is no guidance on how to evaluate this issue. Methods: Since B-cell precursors, mast cells and nucleated red blood cells are normally absent in peripheral blood, we analyzed them in 1404 bone marrow (BM) aspirates obtained in numerous disease settings and in 85 healthy adults (HA). Results: First, we confirmed the systematic detection of the three populations in HA, as well as the nonreduced numbers with aging. Pairwise comparisons between HA and MM patients grouped according to age and treatment showed significant variability, suggesting that hemodilution should be preferably evaluated with references obtained from patients treated with identical regimens. Leveraging the MRD results from 118 patients, we showed that a comparison with HA of similar age could also inform on potential hemodilution. Conclusions: Our study supports the routine assessment of BM cellularity to evaluate hemodilution, since reduced BM-specific cell types as compared to reference values (either treatment-specific or from HA if the former are unavailable) could indicate hemodilution and a false-negative MRD result.This study was supported by grants from the Centro de Investigación Biomédica en Red—Área de Oncología—del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369, CB16/12/00400, CB16/12/00233 and CB16/12/00284); Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria and co-financed by FEDER funds (FIS No. PI15/01956, PI15/02049, PI15/02062, PI18/01709, PI18/01673 and PI19/01451); the Cancer Research UK (C355/A26819), FCAECC and AIRC under the Accelerator Award Programme (EDITOR); the Black Swan Research Initiative of the International Myeloma Foundation and the European Research Council (ERC) 2015 Starting Grant (Contract 680200 MYELOMANEXT). This study was supported by the Riney Family Multiple Myeloma Research Program Fund.Multidisciplinary Digital Publishing InstituteCentro de Investigación Biomédica en Red Cáncer (España)Instituto de Salud Carlos IIIEuropean CommissionCancer Research UKFundación Científica Asociación Española Contra el CáncerAssociazione Italiana per la Ricerca sul CancroInternational Myeloma FoundationEuropean Research CouncilPaula and Rodger Riney FoundationConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/262057reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/680200http://dx.doi.org/10.3390/cancers13194924Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2620572026-05-22T06:33:51Z |
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15,811543 |