Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish

Background: Melatonin is a key hormone in regulation of circadian rhythms, and involved in many rhythmic functions, such as feeding and locomotor activity. Melatonin reportedly counteracts stress responses in many vertebrates, including fish. However, targets for this action of melatonin and underly...

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Autores: Azpeleta Noriega, Clara, Delgado, María Jesús, Metz, Juriaan R., Flik, Gert, Petro, Nuria de
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universidad Europea (UEM)
Repositório:ABACUS. Repositorio de Producción Científica
Idioma:inglês
OAI Identifier:oai:abacus.universidadeuropea.com:11268/12889
Acesso em linha:http://hdl.handle.net/11268/12889
Access Level:Acceso aberto
Palavra-chave:Fisiología
Efectos fisiológicos
Goal 3: Ensure healthy lives and promote well-being for all at all ages
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spelling Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfishAzpeleta Noriega, ClaraDelgado, María JesúsMetz, Juriaan R.Flik, GertPetro, Nuria deFisiologíaEfectos fisiológicosGoal 3: Ensure healthy lives and promote well-being for all at all agesBackground: Melatonin is a key hormone in regulation of circadian rhythms, and involved in many rhythmic functions, such as feeding and locomotor activity. Melatonin reportedly counteracts stress responses in many vertebrates, including fish. However, targets for this action of melatonin and underlying mechanisms remain unknown. Results: This study reports potential anti-stress properties of melatonin in goldfish (Carassius auratus), with a focus on its effect on plasma cortisol, food intake, and locomotor activity, all of them involved in the responses to stress exposure. Indeed, acute injection of melatonin counteracted stress-induced hypercortisolinemia and reduced food intake. The reduced locomotor activity following melatonin treatment suggests a possible sedative role in fish. To assess whether this anti-stress effects of melatonin involve direct actions on interrenal tissue, in vitro cultures of head kidney (containing the interrenal cortisol-producing tissue) were carried out in presence of ACTH, melatonin, and luzindole, an antagonist of melatonin receptors. Melatonin in vitro reduced ACTH-stimulated cortisol release, an effect attenuated by luzindole; this suggests the presence of specific melatonin receptors in interrenal tissue. Conclusions: Our data support a role for melatonin as an anti-stress signal in goldfish, and suggest that the interrenal tissue of teleosts may be a plausible target for melatonin action decreasing cortisol production.20242024-06-0220242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/12889reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/128892026-06-11T12:41:27Z
dc.title.none.fl_str_mv Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
title Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
spellingShingle Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
Azpeleta Noriega, Clara
Fisiología
Efectos fisiológicos
Goal 3: Ensure healthy lives and promote well-being for all at all ages
title_short Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
title_full Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
title_fullStr Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
title_full_unstemmed Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
title_sort Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
dc.creator.none.fl_str_mv Azpeleta Noriega, Clara
Delgado, María Jesús
Metz, Juriaan R.
Flik, Gert
Petro, Nuria de
author Azpeleta Noriega, Clara
author_facet Azpeleta Noriega, Clara
Delgado, María Jesús
Metz, Juriaan R.
Flik, Gert
Petro, Nuria de
author_role author
author2 Delgado, María Jesús
Metz, Juriaan R.
Flik, Gert
Petro, Nuria de
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Fisiología
Efectos fisiológicos
Goal 3: Ensure healthy lives and promote well-being for all at all ages
topic Fisiología
Efectos fisiológicos
Goal 3: Ensure healthy lives and promote well-being for all at all ages
description Background: Melatonin is a key hormone in regulation of circadian rhythms, and involved in many rhythmic functions, such as feeding and locomotor activity. Melatonin reportedly counteracts stress responses in many vertebrates, including fish. However, targets for this action of melatonin and underlying mechanisms remain unknown. Results: This study reports potential anti-stress properties of melatonin in goldfish (Carassius auratus), with a focus on its effect on plasma cortisol, food intake, and locomotor activity, all of them involved in the responses to stress exposure. Indeed, acute injection of melatonin counteracted stress-induced hypercortisolinemia and reduced food intake. The reduced locomotor activity following melatonin treatment suggests a possible sedative role in fish. To assess whether this anti-stress effects of melatonin involve direct actions on interrenal tissue, in vitro cultures of head kidney (containing the interrenal cortisol-producing tissue) were carried out in presence of ACTH, melatonin, and luzindole, an antagonist of melatonin receptors. Melatonin in vitro reduced ACTH-stimulated cortisol release, an effect attenuated by luzindole; this suggests the presence of specific melatonin receptors in interrenal tissue. Conclusions: Our data support a role for melatonin as an anti-stress signal in goldfish, and suggest that the interrenal tissue of teleosts may be a plausible target for melatonin action decreasing cortisol production.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-06-02
2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/12889
url http://hdl.handle.net/11268/12889
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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