Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)

Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze th...

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Autores: García-Pérez, Javier, Fernandez de Larrea-Baz, Nerea, Lope Carvajal, Virginia, Molina, Antonio J., O'Callaghan-Gordo, Cristina, Alonso, María Henar, Rodríguez-Suárez, Marta María, Mirón-Pozo, Benito, Alguacil, Juan, Gómez-Acebo, Inés, Ascunce, Nieves, Vanaclocha-Espi, Mercedes, Amiano, Pilar, Chirlaque, María-Dolores, Simó, Vicente, Jimenez-Moleon, Jose J., Tardón, Adonina, Moreno, Victor, Castaño-Vinyals, Gemma, Martín, Vicente, Aragones, Nuria, Perez-Gomez, Beatriz, Kogevinas, Manolis, Pollan-Santamaria, Marina
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/11027
Acesso em linha:http://hdl.handle.net/20.500.12105/11027
Access Level:acceso abierto
Palavra-chave:Colorectal cancer
Industrial pollution
MCC-Spain
Case-control study
Residential proximit
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spelling Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)García-Pérez, JavierFernandez de Larrea-Baz, NereaLope Carvajal, VirginiaMolina, Antonio J.O'Callaghan-Gordo, CristinaAlonso, María HenarRodríguez-Suárez, Marta MaríaMirón-Pozo, BenitoAlguacil, JuanGómez-Acebo, InésAscunce, NievesVanaclocha-Espi, MercedesAmiano, PilarChirlaque, María-DoloresSimó, VicenteJimenez-Moleon, Jose J.Tardón, AdoninaMoreno, VictorCastaño-Vinyals, GemmaMartín, VicenteAragones, NuriaPerez-Gomez, BeatrizKogevinas, ManolisPollan-Santamaria, MarinaColorectal cancerIndustrial pollutionMCC-SpainCase-control studyResidential proximitBackground: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects' residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44-2.87) to 3 km (1.26; 1.00-1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77-4.00), surface treatment of metals (1.48; 1.08-2.02), glass and mineral fibers (2.06; 1.39-3.07), organic chemical industry (4.80; 3.20-7.20), inorganic chemical industry (6.74; 4.38-10.36), food/beverage sector (3.34; 2.38-4.68), and surface treatment using organic solvents (6.16; 4.06-9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91-14.28), antimony (5.30; 3.45-8.15), naphthalene (3.11; 2.16-4.49), organotin compounds (2.64; 1.76-3.98), manganese (2.53; 1.63-3.93), dichloromethane (2.52; 1.74-3.66), and vanadium (2.49; 1.59-3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.ElsevierAsociación Española Contra el CáncerInstituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Fundación Marqués de ValdecillaFundación Caja de Ahorros de AsturiasBasque Government (España)Generalitat Valenciana (España)Regional Government of Andalusia (España)Government of Catalonia (España)Fundación La CaixaUnión Europea. Comisión EuropeaCentro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)20202020-09-1620202020-08-1920202020-08-19research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/11027reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/110272026-06-12T12:43:37Z
dc.title.none.fl_str_mv Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
title Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
spellingShingle Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
García-Pérez, Javier
Colorectal cancer
Industrial pollution
MCC-Spain
Case-control study
Residential proximit
title_short Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
title_full Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
title_fullStr Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
title_full_unstemmed Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
title_sort Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
dc.creator.none.fl_str_mv García-Pérez, Javier
Fernandez de Larrea-Baz, Nerea
Lope Carvajal, Virginia
Molina, Antonio J.
O'Callaghan-Gordo, Cristina
Alonso, María Henar
Rodríguez-Suárez, Marta María
Mirón-Pozo, Benito
Alguacil, Juan
Gómez-Acebo, Inés
Ascunce, Nieves
Vanaclocha-Espi, Mercedes
Amiano, Pilar
Chirlaque, María-Dolores
Simó, Vicente
Jimenez-Moleon, Jose J.
Tardón, Adonina
Moreno, Victor
Castaño-Vinyals, Gemma
Martín, Vicente
Aragones, Nuria
Perez-Gomez, Beatriz
Kogevinas, Manolis
Pollan-Santamaria, Marina
author García-Pérez, Javier
author_facet García-Pérez, Javier
Fernandez de Larrea-Baz, Nerea
Lope Carvajal, Virginia
Molina, Antonio J.
O'Callaghan-Gordo, Cristina
Alonso, María Henar
Rodríguez-Suárez, Marta María
Mirón-Pozo, Benito
Alguacil, Juan
Gómez-Acebo, Inés
Ascunce, Nieves
Vanaclocha-Espi, Mercedes
Amiano, Pilar
Chirlaque, María-Dolores
Simó, Vicente
Jimenez-Moleon, Jose J.
Tardón, Adonina
Moreno, Victor
Castaño-Vinyals, Gemma
Martín, Vicente
Aragones, Nuria
Perez-Gomez, Beatriz
Kogevinas, Manolis
Pollan-Santamaria, Marina
author_role author
author2 Fernandez de Larrea-Baz, Nerea
Lope Carvajal, Virginia
Molina, Antonio J.
O'Callaghan-Gordo, Cristina
Alonso, María Henar
Rodríguez-Suárez, Marta María
Mirón-Pozo, Benito
Alguacil, Juan
Gómez-Acebo, Inés
Ascunce, Nieves
Vanaclocha-Espi, Mercedes
Amiano, Pilar
Chirlaque, María-Dolores
Simó, Vicente
Jimenez-Moleon, Jose J.
Tardón, Adonina
Moreno, Victor
Castaño-Vinyals, Gemma
Martín, Vicente
Aragones, Nuria
Perez-Gomez, Beatriz
Kogevinas, Manolis
Pollan-Santamaria, Marina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Asociación Española Contra el Cáncer
Instituto de Salud Carlos III
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Fundación Marqués de Valdecilla
Fundación Caja de Ahorros de Asturias
Basque Government (España)
Generalitat Valenciana (España)
Regional Government of Andalusia (España)
Government of Catalonia (España)
Fundación La Caixa
Unión Europea. Comisión Europea
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
dc.subject.none.fl_str_mv Colorectal cancer
Industrial pollution
MCC-Spain
Case-control study
Residential proximit
topic Colorectal cancer
Industrial pollution
MCC-Spain
Case-control study
Residential proximit
description Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects' residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44-2.87) to 3 km (1.26; 1.00-1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77-4.00), surface treatment of metals (1.48; 1.08-2.02), glass and mineral fibers (2.06; 1.39-3.07), organic chemical industry (4.80; 3.20-7.20), inorganic chemical industry (6.74; 4.38-10.36), food/beverage sector (3.34; 2.38-4.68), and surface treatment using organic solvents (6.16; 4.06-9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91-14.28), antimony (5.30; 3.45-8.15), naphthalene (3.11; 2.16-4.49), organotin compounds (2.64; 1.76-3.98), manganese (2.53; 1.63-3.93), dichloromethane (2.52; 1.74-3.66), and vanadium (2.49; 1.59-3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-09-16
2020
2020-08-19
2020
2020-08-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/11027
url http://hdl.handle.net/20.500.12105/11027
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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