Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown etiology. Many metabolic alterations occur during ALS progress and can be used as a method of pre-diagnostic and early diagnosis. Dyslipidemia is one of the physiological changes observed in numerous ALS patients....

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Authors: Pardo Moreno, T., Mohamed Mohamed, Himan, Suleiman Martos, Sami, Ramos Rodríguez, J.J., Rivas Domínguez, Antonio, Melguizo Rodríguez, L., Gómez Urquiza, J.L., Bermúdez Pulgarín, Beatriz, García Morales, V.
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/155239
Online Access:https://hdl.handle.net/11441/155239
https://doi.org/10.3390/ijms24108675
Access Level:Open access
Keyword:Amyotrophic lateral sclerosis
Cholesterol
Lipids
Meta-analysis
Neurodegeneration
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spelling Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic StudyPardo Moreno, T.Mohamed Mohamed, HimanSuleiman Martos, SamiRamos Rodríguez, J.J.Rivas Domínguez, AntonioMelguizo Rodríguez, L.Gómez Urquiza, J.L.Bermúdez Pulgarín, BeatrizGarcía Morales, V.Amyotrophic lateral sclerosisCholesterolLipidsMeta-analysisNeurodegenerationAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown etiology. Many metabolic alterations occur during ALS progress and can be used as a method of pre-diagnostic and early diagnosis. Dyslipidemia is one of the physiological changes observed in numerous ALS patients. The aim of this study is to analyze the possible relationship between the rate of disease progression (functional rating scale (ALS-FRS)) and the plasma lipid levels at the early stage of ALS. A systematic review was carried out in July 2022. The search equation was “Triglycerides AND amyotrophic lateral sclerosis” and its variants. Four meta-analyses were performed. Four studies were included in the meta-analysis. No significant differences were observed between the lipid levels (total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol) and the ALS-FRS score at the onset of the disease. Although the number of studies included in this research was low, the results of this meta-analytic study suggest that there is no clear relationship between the symptoms observed in ALS patients and the plasma lipid levels. An increase in research, as well as an expansion of the geographical area, would be of interest.Junta de Andalucía P20-01061, P18-RT-3324Ministerio de Ciencia e Innovación PID2019-110960GB-I00Multidisciplinary Digital Publishing Institute (MDPI)Biología CelularJunta de AndalucíaMinisterio de Ciencia e Innovación (MICIN). España2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/155239https://doi.org/10.3390/ijms24108675reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Molecular Sciences, 24 (10), 8675.P20-01061P18-RT-3324PID2019-110960GB-I00https://doi.org/10.3390/ijms24108675info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1552392026-06-17T12:51:07Z
dc.title.none.fl_str_mv Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
title Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
spellingShingle Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
Pardo Moreno, T.
Amyotrophic lateral sclerosis
Cholesterol
Lipids
Meta-analysis
Neurodegeneration
title_short Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
title_full Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
title_fullStr Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
title_full_unstemmed Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
title_sort Amyotrophic Lateral Sclerosis and Serum Lipid Level Association: A Systematic Review and Meta-Analytic Study
dc.creator.none.fl_str_mv Pardo Moreno, T.
Mohamed Mohamed, Himan
Suleiman Martos, Sami
Ramos Rodríguez, J.J.
Rivas Domínguez, Antonio
Melguizo Rodríguez, L.
Gómez Urquiza, J.L.
Bermúdez Pulgarín, Beatriz
García Morales, V.
author Pardo Moreno, T.
author_facet Pardo Moreno, T.
Mohamed Mohamed, Himan
Suleiman Martos, Sami
Ramos Rodríguez, J.J.
Rivas Domínguez, Antonio
Melguizo Rodríguez, L.
Gómez Urquiza, J.L.
Bermúdez Pulgarín, Beatriz
García Morales, V.
author_role author
author2 Mohamed Mohamed, Himan
Suleiman Martos, Sami
Ramos Rodríguez, J.J.
Rivas Domínguez, Antonio
Melguizo Rodríguez, L.
Gómez Urquiza, J.L.
Bermúdez Pulgarín, Beatriz
García Morales, V.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biología Celular
Junta de Andalucía
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv Amyotrophic lateral sclerosis
Cholesterol
Lipids
Meta-analysis
Neurodegeneration
topic Amyotrophic lateral sclerosis
Cholesterol
Lipids
Meta-analysis
Neurodegeneration
description Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown etiology. Many metabolic alterations occur during ALS progress and can be used as a method of pre-diagnostic and early diagnosis. Dyslipidemia is one of the physiological changes observed in numerous ALS patients. The aim of this study is to analyze the possible relationship between the rate of disease progression (functional rating scale (ALS-FRS)) and the plasma lipid levels at the early stage of ALS. A systematic review was carried out in July 2022. The search equation was “Triglycerides AND amyotrophic lateral sclerosis” and its variants. Four meta-analyses were performed. Four studies were included in the meta-analysis. No significant differences were observed between the lipid levels (total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol) and the ALS-FRS score at the onset of the disease. Although the number of studies included in this research was low, the results of this meta-analytic study suggest that there is no clear relationship between the symptoms observed in ALS patients and the plasma lipid levels. An increase in research, as well as an expansion of the geographical area, would be of interest.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/155239
https://doi.org/10.3390/ijms24108675
url https://hdl.handle.net/11441/155239
https://doi.org/10.3390/ijms24108675
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences, 24 (10), 8675.
P20-01061
P18-RT-3324
PID2019-110960GB-I00
https://doi.org/10.3390/ijms24108675
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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