The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon

Network analysis may improve the understanding of malaria epidemiology in rural areas of the Amazon region by explicitly representing the relationships between villages as a proxy for human population mobility. This study tests a comprehensive set of connectivity metrics and their relationship with...

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Detalhes bibliográficos
Autores: Carrasco Escobar, Gabriel, Villa, Diego, Antony, Barja, Lowe, Rachel, Llanos Cuentas, Alejandro, Benmarhnia, Tarik
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositório:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglês
OAI Identifier:oai:upcommons.upc.edu:2117/419002
Acesso em linha:https://hdl.handle.net/2117/419002
https://dx.doi.org/10.1371/journal.pntd.0012560
Access Level:Acceso aberto
Palavra-chave:Malaria dynamics
Peruvian Amazon
Rural areas
Climatic factors
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina comunitària i salut pública
Àrees temàtiques de la UPC::Desenvolupament humà i sostenible::Degradació ambiental::Canvi climàtic
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spelling The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian AmazonCarrasco Escobar, GabrielVilla, DiegoAntony, BarjaLowe, RachelLlanos Cuentas, AlejandroBenmarhnia, TarikMalaria dynamicsPeruvian AmazonRural areasClimatic factorsÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina comunitària i salut públicaÀrees temàtiques de la UPC::Desenvolupament humà i sostenible::Degradació ambiental::Canvi climàticNetwork analysis may improve the understanding of malaria epidemiology in rural areas of the Amazon region by explicitly representing the relationships between villages as a proxy for human population mobility. This study tests a comprehensive set of connectivity metrics and their relationship with malaria incidence across villages with contrasting PAMAFRO (a malaria control initiative) coverage levels in the Loreto department of Peru using data from the passive case detection reports from the Peruvian Ministry of Health between 2011 and 2018 at the village level. A total of 24 centrality metrics were computed and tested on 1608 nodes (i.e., villages/cities). Based on its consistency and stability, the betweenness centrality type outperformed other metrics. No appreciable differences in the distributions of malaria incidence were found when using different weights, including population, deforested area, Euclidian distance, or travel time. Overall, villages in the top quintile of centrality have a higher malaria incidence in comparison with villages in the bottom quintile of centrality (Mean Difference in cases per 1000 population; P. vivax = 165.78 and P. falciparum = 76.14). The mean difference between villages at the top and bottom centrality quintiles increases as PAMAFRO coverage increases for both P. vivax (Tier 1 = 155.36; Tier 2 = 176.22; Tier 3 = 326.08) and P. falciparum (Tier 1 = 48.11; Tier 2 = 95.16; Tier 3 = 139.07). The findings of this study support the shift in current malaria control strategies from targeting specific locations based on malaria metrics to strategies based on connectivity neighborhoods that include influential connected villages.The author(s) received no specific funding for this work.Peer ReviewedPublic Library of Science20242024-11-0420242024-11-22journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/419002https://dx.doi.org/10.1371/journal.pntd.0012560reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4190022026-05-27T15:37:01Z
dc.title.none.fl_str_mv The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
title The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
spellingShingle The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
Carrasco Escobar, Gabriel
Malaria dynamics
Peruvian Amazon
Rural areas
Climatic factors
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina comunitària i salut pública
Àrees temàtiques de la UPC::Desenvolupament humà i sostenible::Degradació ambiental::Canvi climàtic
title_short The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
title_full The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
title_fullStr The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
title_full_unstemmed The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
title_sort The role of connectivity on malaria dynamics across areas with contrasting control coverage in the Peruvian Amazon
dc.creator.none.fl_str_mv Carrasco Escobar, Gabriel
Villa, Diego
Antony, Barja
Lowe, Rachel
Llanos Cuentas, Alejandro
Benmarhnia, Tarik
author Carrasco Escobar, Gabriel
author_facet Carrasco Escobar, Gabriel
Villa, Diego
Antony, Barja
Lowe, Rachel
Llanos Cuentas, Alejandro
Benmarhnia, Tarik
author_role author
author2 Villa, Diego
Antony, Barja
Lowe, Rachel
Llanos Cuentas, Alejandro
Benmarhnia, Tarik
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malaria dynamics
Peruvian Amazon
Rural areas
Climatic factors
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina comunitària i salut pública
Àrees temàtiques de la UPC::Desenvolupament humà i sostenible::Degradació ambiental::Canvi climàtic
topic Malaria dynamics
Peruvian Amazon
Rural areas
Climatic factors
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina comunitària i salut pública
Àrees temàtiques de la UPC::Desenvolupament humà i sostenible::Degradació ambiental::Canvi climàtic
description Network analysis may improve the understanding of malaria epidemiology in rural areas of the Amazon region by explicitly representing the relationships between villages as a proxy for human population mobility. This study tests a comprehensive set of connectivity metrics and their relationship with malaria incidence across villages with contrasting PAMAFRO (a malaria control initiative) coverage levels in the Loreto department of Peru using data from the passive case detection reports from the Peruvian Ministry of Health between 2011 and 2018 at the village level. A total of 24 centrality metrics were computed and tested on 1608 nodes (i.e., villages/cities). Based on its consistency and stability, the betweenness centrality type outperformed other metrics. No appreciable differences in the distributions of malaria incidence were found when using different weights, including population, deforested area, Euclidian distance, or travel time. Overall, villages in the top quintile of centrality have a higher malaria incidence in comparison with villages in the bottom quintile of centrality (Mean Difference in cases per 1000 population; P. vivax = 165.78 and P. falciparum = 76.14). The mean difference between villages at the top and bottom centrality quintiles increases as PAMAFRO coverage increases for both P. vivax (Tier 1 = 155.36; Tier 2 = 176.22; Tier 3 = 326.08) and P. falciparum (Tier 1 = 48.11; Tier 2 = 95.16; Tier 3 = 139.07). The findings of this study support the shift in current malaria control strategies from targeting specific locations based on malaria metrics to strategies based on connectivity neighborhoods that include influential connected villages.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-11-04
2024
2024-11-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/419002
https://dx.doi.org/10.1371/journal.pntd.0012560
url https://hdl.handle.net/2117/419002
https://dx.doi.org/10.1371/journal.pntd.0012560
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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