Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics

Multidimensional separation systems have arisen in the last years to overcome certain limitations of the classical one-dimensional separations. Multidimensional analytical approaches achieve a greater separation power, a crucial aspect when dealing with highly complex samples, as in metabolomics and...

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Detalhes bibliográficos
Autores: Pérez-Cova, Miriam, Tauler, Romà, Jaumot, Joaquim
Formato: otro
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/225094
Acesso em linha:http://hdl.handle.net/10261/225094
Access Level:acceso abierto
Palavra-chave:Lipidomics
Metabolomics
Two-dimensional liquid chromatography
LC×LC-MS
Comprehensive
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spelling Two-Dimensional Liquid Chromatography in Metabolomics and LipidomicsPérez-Cova, MiriamTauler, RomàJaumot, JoaquimLipidomicsMetabolomicsTwo-dimensional liquid chromatographyLC×LC-MSComprehensiveMultidimensional separation systems have arisen in the last years to overcome certain limitations of the classical one-dimensional separations. Multidimensional analytical approaches achieve a greater separation power, a crucial aspect when dealing with highly complex samples, as in metabolomics and lipidomics. Online comprehensive two-dimensional chromatography is a particularly interesting mode when pursuing untargeted analysis, which allows for separating, and consequently identifying a more extensive number of analytes. This chapter aims to summarize current applications of 2D-LC to the fields of metabolomics and lipidomics, and setups of different separation mechanism that are being employed, showing the most suitable combinations of chromatographic modes, depending on the target compounds.The research leading to these results has received funding from the Spanish Ministry of Science and Innovation (MCI, Grant CTQ2017-82598-P). MPC acknowledges a predoctoral FPU 16/02640 scholarship from Spanish Ministry of Education and Vocational Training (MEFP).Peer reviewedSpringer NatureMinisterio de Ciencia e Innovación (España)Tauler, Romà [0000-0001-8559-9670]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Postprintinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/225094reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-82598-Phttps://doi.org/10.1007/978-1-0716-0864-7_3Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2250942026-05-22T06:33:51Z
dc.title.none.fl_str_mv Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
title Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
spellingShingle Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
Pérez-Cova, Miriam
Lipidomics
Metabolomics
Two-dimensional liquid chromatography
LC×LC-MS
Comprehensive
title_short Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
title_full Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
title_fullStr Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
title_full_unstemmed Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
title_sort Two-Dimensional Liquid Chromatography in Metabolomics and Lipidomics
dc.creator.none.fl_str_mv Pérez-Cova, Miriam
Tauler, Romà
Jaumot, Joaquim
author Pérez-Cova, Miriam
author_facet Pérez-Cova, Miriam
Tauler, Romà
Jaumot, Joaquim
author_role author
author2 Tauler, Romà
Jaumot, Joaquim
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Tauler, Romà [0000-0001-8559-9670]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lipidomics
Metabolomics
Two-dimensional liquid chromatography
LC×LC-MS
Comprehensive
topic Lipidomics
Metabolomics
Two-dimensional liquid chromatography
LC×LC-MS
Comprehensive
description Multidimensional separation systems have arisen in the last years to overcome certain limitations of the classical one-dimensional separations. Multidimensional analytical approaches achieve a greater separation power, a crucial aspect when dealing with highly complex samples, as in metabolomics and lipidomics. Online comprehensive two-dimensional chromatography is a particularly interesting mode when pursuing untargeted analysis, which allows for separating, and consequently identifying a more extensive number of analytes. This chapter aims to summarize current applications of 2D-LC to the fields of metabolomics and lipidomics, and setups of different separation mechanism that are being employed, showing the most suitable combinations of chromatographic modes, depending on the target compounds.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Postprint
info:eu-repo/semantics/acceptedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/225094
url http://hdl.handle.net/10261/225094
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-82598-P
https://doi.org/10.1007/978-1-0716-0864-7_3
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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