Individual differences in hippocampal volume as a function of BMI and reward sensitivity

Sensitivity to reward is a personality trait that predisposes a person to several addictive behaviors, including the presence of different risky behaviors that facilitates uncontrolled eating. However, the multifactorial nature of obesity blurs a direct relationship between the two factors. Here, we...

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Autores: Parcet, Maria-Antònia, Adrián Ventura, Jesús, Costumero, Víctor, Ávila, César
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/44467
Acceso en línea:http://hdl.handle.net/10230/44467
http://dx.doi.org/10.3389/fnbeh.2020.00053
Access Level:acceso abierto
Palabra clave:Reward sensitivity
Body mass index
Hippocampus
Voxel-based morphometry
Obesity
Reinforcement sensitivity theory
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spelling Individual differences in hippocampal volume as a function of BMI and reward sensitivityParcet, Maria-AntòniaAdrián Ventura, JesúsCostumero, VíctorÁvila, CésarReward sensitivityBody mass indexHippocampusVoxel-based morphometryObesityReinforcement sensitivity theorySensitivity to reward is a personality trait that predisposes a person to several addictive behaviors, including the presence of different risky behaviors that facilitates uncontrolled eating. However, the multifactorial nature of obesity blurs a direct relationship between the two factors. Here, we studied the brain anatomic correlates of the interaction between reward sensitivity and body mass index (BMI) to investigate whether the coexistence of high BMI and high reward sensitivity structurally alters brain areas specifically involved in the regulation of eating behavior. To achieve this aim, we acquired T1-weighted images and measured reward sensitivity using the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) and BMI in a sample of 206 adults. Results showed that reward sensitivity and BMI were not significantly correlated. However, neuroimaging results confirmed a relationship between BMI and reduced volume in the medial and lateral orbitofrontal cortex, and between reward sensitivity and lower striatum volume. Importantly, the interaction between the two factors was significantly related to the right anterior hippocampus volume, showing that stronger reward sensitivity plus a higher BMI were associated with reduced hippocampal volume. The hippocampus is a brain structure involved in the higher-order regulation of feeding behavior. Thus, a dysfunctional hippocampus may contribute to maintaining a vicious cycle that predisposes people to obesity.This work was supported by grants from Generalitat Valenciana (AICO/2018/038), Universitat Jaume I (UJI-B2018-22) and Ministerio de Economía y Competitividad (PSI2016-78805-R) to CÁA. This work was also supported by a pre-doctoral graduate program grant (National FPU to JA-V) and a post-doctoral graduate program grant (Juan de la Cierva to VC).Frontiers202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44467http://dx.doi.org/10.3389/fnbeh.2020.00053reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Behavioral Neuroscience. 2020 Apr 9;14:53info:eu-repo/grantAgreement/ES/1PE/PSI2016-78805-R© 2020 Parcet, Adrián-Ventura, Costumero and Ávila. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/444672026-05-29T05:05:01Z
dc.title.none.fl_str_mv Individual differences in hippocampal volume as a function of BMI and reward sensitivity
title Individual differences in hippocampal volume as a function of BMI and reward sensitivity
spellingShingle Individual differences in hippocampal volume as a function of BMI and reward sensitivity
Parcet, Maria-Antònia
Reward sensitivity
Body mass index
Hippocampus
Voxel-based morphometry
Obesity
Reinforcement sensitivity theory
title_short Individual differences in hippocampal volume as a function of BMI and reward sensitivity
title_full Individual differences in hippocampal volume as a function of BMI and reward sensitivity
title_fullStr Individual differences in hippocampal volume as a function of BMI and reward sensitivity
title_full_unstemmed Individual differences in hippocampal volume as a function of BMI and reward sensitivity
title_sort Individual differences in hippocampal volume as a function of BMI and reward sensitivity
dc.creator.none.fl_str_mv Parcet, Maria-Antònia
Adrián Ventura, Jesús
Costumero, Víctor
Ávila, César
author Parcet, Maria-Antònia
author_facet Parcet, Maria-Antònia
Adrián Ventura, Jesús
Costumero, Víctor
Ávila, César
author_role author
author2 Adrián Ventura, Jesús
Costumero, Víctor
Ávila, César
author2_role author
author
author
dc.subject.none.fl_str_mv Reward sensitivity
Body mass index
Hippocampus
Voxel-based morphometry
Obesity
Reinforcement sensitivity theory
topic Reward sensitivity
Body mass index
Hippocampus
Voxel-based morphometry
Obesity
Reinforcement sensitivity theory
description Sensitivity to reward is a personality trait that predisposes a person to several addictive behaviors, including the presence of different risky behaviors that facilitates uncontrolled eating. However, the multifactorial nature of obesity blurs a direct relationship between the two factors. Here, we studied the brain anatomic correlates of the interaction between reward sensitivity and body mass index (BMI) to investigate whether the coexistence of high BMI and high reward sensitivity structurally alters brain areas specifically involved in the regulation of eating behavior. To achieve this aim, we acquired T1-weighted images and measured reward sensitivity using the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) and BMI in a sample of 206 adults. Results showed that reward sensitivity and BMI were not significantly correlated. However, neuroimaging results confirmed a relationship between BMI and reduced volume in the medial and lateral orbitofrontal cortex, and between reward sensitivity and lower striatum volume. Importantly, the interaction between the two factors was significantly related to the right anterior hippocampus volume, showing that stronger reward sensitivity plus a higher BMI were associated with reduced hippocampal volume. The hippocampus is a brain structure involved in the higher-order regulation of feeding behavior. Thus, a dysfunctional hippocampus may contribute to maintaining a vicious cycle that predisposes people to obesity.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/44467
http://dx.doi.org/10.3389/fnbeh.2020.00053
url http://hdl.handle.net/10230/44467
http://dx.doi.org/10.3389/fnbeh.2020.00053
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Behavioral Neuroscience. 2020 Apr 9;14:53
info:eu-repo/grantAgreement/ES/1PE/PSI2016-78805-R
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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