Electrochemical NHPI catalyzed addition of a-alkoxy radicals to oxime ethers
In this work, we describe how N-hydroxyphthalimide (NHPI), also under catalytic amounts, promotes hydrogen atom transfer (HAT) from alcohols under electrochemical conditions through the generation of phthalimide-N-oxyl (PINO). In contrast with the well-known electrochemical oxidation to their corres...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/751500 |
| Acceso en línea: | https://hdl.handle.net/10486/751500 https://dx.doi.org/10.1002/adsc.70291 |
| Access Level: | acceso abierto |
| Palabra clave: | alkyl radical electrocatalysis electrochemistry green chemistry hydrogen atom transfer Química |
| Sumario: | In this work, we describe how N-hydroxyphthalimide (NHPI), also under catalytic amounts, promotes hydrogen atom transfer (HAT) from alcohols under electrochemical conditions through the generation of phthalimide-N-oxyl (PINO). In contrast with the well-known electrochemical oxidation to their corresponding aldehydes or ketones, α-alkoxy radicals were successfully coupled with oximes promoting a carbon–carbon bond-forming event. This method allows the α-functionalization of primary and secondary alcohols under simple, straightforward, and mild electrochemical reaction conditions in a single operation even in the presence of catalytic amounts of the HAT catalyst |
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