Editorial: Basic and applied research toward the development of vaccines against African swine fever virus
African swine fever virus (ASFV) is a complex dsDNA virus that causes a disease that is frequently fatal, ASF. This has a high socio-economic impact. ASFV causes acute disease in both domestic pigs and wild boar. Originating in sub-Saharan Africa, it causes inapparent infections in African wild suid...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/410112 |
| Acceso en línea: | http://hdl.handle.net/10261/410112 |
| Access Level: | acceso abierto |
| Palabra clave: | ASFV Vaccines Virulence factors Innate immunity IFN-I c-GAS/STING Tropism Cell line |
| Sumario: | African swine fever virus (ASFV) is a complex dsDNA virus that causes a disease that is frequently fatal, ASF. This has a high socio-economic impact. ASFV causes acute disease in both domestic pigs and wild boar. Originating in sub-Saharan Africa, it causes inapparent infections in African wild suids, including warthogs, and in soft tick vectors of the virus. Its rapid spread across Europe, Asia, Oceania, and the Caribbean highlights the urgent need for effective vaccines. Currently, live attenuated vaccines (LAVs) represent the most effective approach, though these have limited availability and possible safety concerns. For ASF-free regions, developing alternative approaches such as vector, subunit, or replication-deficient vaccines may be more appropriate, but this requires greater knowledge of the mechanisms and antigens that are important for protection. Factors limiting vaccine development include the large number of proteins encoded, limited knowledge of the virus replication and immune evasion, factors influencing host and cellular tropism, efficient cell lines for the growth of vaccine prototypes, and poor understanding of mechanisms and correlates of pathogenesis and protection in pigs. This Research Topic, titled “Basic and Applied Research Toward the Development of Vaccines Against African Swine Fever Virus,” aims to highlight important developments in this critical area of research, from pathogenesis and immune response to functional topics such as vaccination and diagnostic tools and strategies. |
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