Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product

Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were re...

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Autores: Xargay i Torrent, Sílvia, Espuña Capote, Núria, Montesinos Costa, Mercè, Prats Puig, Anna, Carreras Badosa, Gemma, Díaz Roldán, Ferran, Zegher, Francis de, Ibáñez Toda, Lourdes, Bassols, Judit, López Bermejo, Abel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/156561
Acceso en línea:https://hdl.handle.net/2445/156561
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Factors de risc en les malalties
Malalties dels infants
Cardiovascular diseases
Risk factors in diseases
Children's diseases
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spelling Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus productXargay i Torrent, SílviaEspuña Capote, NúriaMontesinos Costa, MercèPrats Puig, AnnaCarreras Badosa, GemmaDíaz Roldán, FerranZegher, Francis deIbáñez Toda, LourdesBassols, JuditLópez Bermejo, AbelMalalties cardiovascularsFactors de risc en les malaltiesMalalties dels infantsCardiovascular diseasesRisk factors in diseasesChildren's diseasesAlthough alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (p < 0.0001), waist circumference (p < 0.0001), SBP (p < 0.0001), cIMT (p = 0.005), HOMA-IR (p < 0.0001), and fasting triglycerides (p = 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231; p = 0.001), waist (r = 0.252; p < 0.0001), SBP (r = 0.324; p < 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291; p < 0.0001)]. ALP independently associated with SBP (β = 0.290, p < 0.001) and cIMT (β = 0.179, p = 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.Nature Publishing Group2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/156561Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-018-35973-5Scientific Reports, 2018, vol. 8, num. 1, p. 17864https://doi.org/10.1038/s41598-018-35973-5cc-by (c) Xargay i Torrent, Sílvia et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1565612026-05-27T06:46:51Z
dc.title.none.fl_str_mv Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
title Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
spellingShingle Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
Xargay i Torrent, Sílvia
Malalties cardiovasculars
Factors de risc en les malalties
Malalties dels infants
Cardiovascular diseases
Risk factors in diseases
Children's diseases
title_short Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
title_full Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
title_fullStr Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
title_full_unstemmed Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
title_sort Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
dc.creator.none.fl_str_mv Xargay i Torrent, Sílvia
Espuña Capote, Núria
Montesinos Costa, Mercè
Prats Puig, Anna
Carreras Badosa, Gemma
Díaz Roldán, Ferran
Zegher, Francis de
Ibáñez Toda, Lourdes
Bassols, Judit
López Bermejo, Abel
author Xargay i Torrent, Sílvia
author_facet Xargay i Torrent, Sílvia
Espuña Capote, Núria
Montesinos Costa, Mercè
Prats Puig, Anna
Carreras Badosa, Gemma
Díaz Roldán, Ferran
Zegher, Francis de
Ibáñez Toda, Lourdes
Bassols, Judit
López Bermejo, Abel
author_role author
author2 Espuña Capote, Núria
Montesinos Costa, Mercè
Prats Puig, Anna
Carreras Badosa, Gemma
Díaz Roldán, Ferran
Zegher, Francis de
Ibáñez Toda, Lourdes
Bassols, Judit
López Bermejo, Abel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Factors de risc en les malalties
Malalties dels infants
Cardiovascular diseases
Risk factors in diseases
Children's diseases
topic Malalties cardiovasculars
Factors de risc en les malalties
Malalties dels infants
Cardiovascular diseases
Risk factors in diseases
Children's diseases
description Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (p < 0.0001), waist circumference (p < 0.0001), SBP (p < 0.0001), cIMT (p = 0.005), HOMA-IR (p < 0.0001), and fasting triglycerides (p = 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231; p = 0.001), waist (r = 0.252; p < 0.0001), SBP (r = 0.324; p < 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291; p < 0.0001)]. ALP independently associated with SBP (β = 0.290, p < 0.001) and cIMT (β = 0.179, p = 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/156561
url https://hdl.handle.net/2445/156561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-35973-5
Scientific Reports, 2018, vol. 8, num. 1, p. 17864
https://doi.org/10.1038/s41598-018-35973-5
dc.rights.none.fl_str_mv cc-by (c) Xargay i Torrent, Sílvia et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Xargay i Torrent, Sílvia et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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