Methylthioadenosine

5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. This compound is metabolized solel...

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Autores: Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f, Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c, Lu, S.C. (Shelly C.)|||/items/e4a2a6d5-e196-42c9-b95b-2a670ce9a801, Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2, Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79
Tipo de recurso: artículo
Fecha de publicación:2004
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/21380
Acceso en línea:https://hdl.handle.net/10171/21380
Access Level:acceso abierto
Palabra clave:Methylthioadenosine
S-adenosylmethionine
MTAP
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repository_id_str
spelling MethylthioadenosineAvila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419fRuiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35cLu, S.C. (Shelly C.)|||/items/e4a2a6d5-e196-42c9-b95b-2a670ce9a801Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79MethylthioadenosineS-adenosylmethionineMTAP5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. This compound is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. Abundant evidence has accumulated over time suggesting that MTA can affect cellular processes in many ways. MTA has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous MTA could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for MTA that deserves further consideration.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20122012-03-2820042004-01-0120042004-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10171/21380reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/213802026-06-21T12:47:57Z
dc.title.none.fl_str_mv Methylthioadenosine
title Methylthioadenosine
spellingShingle Methylthioadenosine
Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f
Methylthioadenosine
S-adenosylmethionine
MTAP
title_short Methylthioadenosine
title_full Methylthioadenosine
title_fullStr Methylthioadenosine
title_full_unstemmed Methylthioadenosine
title_sort Methylthioadenosine
dc.creator.none.fl_str_mv Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f
Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c
Lu, S.C. (Shelly C.)|||/items/e4a2a6d5-e196-42c9-b95b-2a670ce9a801
Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2
Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79
author Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f
author_facet Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f
Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c
Lu, S.C. (Shelly C.)|||/items/e4a2a6d5-e196-42c9-b95b-2a670ce9a801
Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2
Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79
author_role author
author2 Ruiz Garcia-Trevijano, E. (Elena)|||/items/bc37b3f6-83de-42b9-bb68-e90d1296c35c
Lu, S.C. (Shelly C.)|||/items/e4a2a6d5-e196-42c9-b95b-2a670ce9a801
Corrales, F.J. (Fernando José)|||/items/96b34843-1185-4837-be4b-d1d63e688ec2
Mato, J.M. (José María)|||/items/302dc624-b0d3-4703-90cf-1a97690ebc79
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Methylthioadenosine
S-adenosylmethionine
MTAP
topic Methylthioadenosine
S-adenosylmethionine
MTAP
description 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. This compound is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. Abundant evidence has accumulated over time suggesting that MTA can affect cellular processes in many ways. MTA has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous MTA could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for MTA that deserves further consideration.
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01
2004
2004-01-01
2012
2012-03-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/21380
url https://hdl.handle.net/10171/21380
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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