Effects of prolonged ethanol intake and malnutrition on rat pancreas
Nutritional factors, especially the protein and fat content of the diet, may change pancreatic morphology after ethanol induced injury. This study was performed to delineate the combined effects of a low fat diet and longterm ethanol ingestion on the rat pancreas. Male Sprague-Dawley rats were maint...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1996 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/18622 |
| Acesso em linha: | https://hdl.handle.net/2445/18622 |
| Access Level: | acceso abierto |
| Palavra-chave: | Alcohol Efectes fisiològics Desnutrició Ratolins (Animals de laboratori) Pancreas Physiological effect Malnutrition Mice (Laboratory animals) Pàncrees |
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Effects of prolonged ethanol intake and malnutrition on rat pancreasLópez Blanco, José ManuelBombí, Josep AntoniValderrama Labarca, RodrigoGiménez Lagunas, AméricaParés Darnaculleta, AlbertCaballeria Rovira, JoanImperial Ródenas, SantiagoNavarro Colás, SalvadorAlcoholEfectes fisiològicsDesnutricióRatolins (Animals de laboratori)PancreasAlcoholPhysiological effectMalnutritionMice (Laboratory animals)PàncreesNutritional factors, especially the protein and fat content of the diet, may change pancreatic morphology after ethanol induced injury. This study was performed to delineate the combined effects of a low fat diet and longterm ethanol ingestion on the rat pancreas. Male Sprague-Dawley rats were maintained with five different diets for 12 weeks and the pancreas removed on the day they were killed. Rats fed a very low fat diet without ethanol (5% of total calories as lipid) developed malnutrition, pancreatic steatosis, and reduction in zymogen granules content. Animals fed a 35% lipid diet with ethanol also developed pancreatic steatosis but changes in zymogen granules content were not detected. Both malnutrition and longterm ethanol consumption increased pancreatic cholesterol ester content, and their effects were additive. Pancreatic steatosis was accompanied with hypercholesterolaemia. Amylase, lipase, and cholesterol esterase content were reduced in malnourished rats; but longterm ethanol ingestion, regardless of the nutritional state, increased lipase content and decreased amylase. It is suggested that high serum cholesterol concentrations and increased pancreatic lipase activity could cause accumulation of cholesterol esters in acinar cells. Fat accumulation in the pancreas has been reported as the earliest histopathological feature in alcoholic patients and may be responsible for cytotoxic effects on the acinar cells at the level of the cell membrane. Although it is difficult to extrapolate results in this animal study to the human situation, the results presented in this work might explain the higher incidence of pancreatitis is malnourished populations as well as in alcoholic subjects that is reported in dietary surveys.BMJ Group201120111996info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/18622Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.38.2.285Gut, 1996, vol. 38, núm. 2, p. 285-292http://dx.doi.org/10.1136/gut.38.2.285(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1996info:eu-repo/semantics/openAccessoai:recercat.cat:2445/186222026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| title |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| spellingShingle |
Effects of prolonged ethanol intake and malnutrition on rat pancreas López Blanco, José Manuel Alcohol Efectes fisiològics Desnutrició Ratolins (Animals de laboratori) Pancreas Alcohol Physiological effect Malnutrition Mice (Laboratory animals) Pàncrees |
| title_short |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| title_full |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| title_fullStr |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| title_full_unstemmed |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| title_sort |
Effects of prolonged ethanol intake and malnutrition on rat pancreas |
| dc.creator.none.fl_str_mv |
López Blanco, José Manuel Bombí, Josep Antoni Valderrama Labarca, Rodrigo Giménez Lagunas, América Parés Darnaculleta, Albert Caballeria Rovira, Joan Imperial Ródenas, Santiago Navarro Colás, Salvador |
| author |
López Blanco, José Manuel |
| author_facet |
López Blanco, José Manuel Bombí, Josep Antoni Valderrama Labarca, Rodrigo Giménez Lagunas, América Parés Darnaculleta, Albert Caballeria Rovira, Joan Imperial Ródenas, Santiago Navarro Colás, Salvador |
| author_role |
author |
| author2 |
Bombí, Josep Antoni Valderrama Labarca, Rodrigo Giménez Lagunas, América Parés Darnaculleta, Albert Caballeria Rovira, Joan Imperial Ródenas, Santiago Navarro Colás, Salvador |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Alcohol Efectes fisiològics Desnutrició Ratolins (Animals de laboratori) Pancreas Alcohol Physiological effect Malnutrition Mice (Laboratory animals) Pàncrees |
| topic |
Alcohol Efectes fisiològics Desnutrició Ratolins (Animals de laboratori) Pancreas Alcohol Physiological effect Malnutrition Mice (Laboratory animals) Pàncrees |
| description |
Nutritional factors, especially the protein and fat content of the diet, may change pancreatic morphology after ethanol induced injury. This study was performed to delineate the combined effects of a low fat diet and longterm ethanol ingestion on the rat pancreas. Male Sprague-Dawley rats were maintained with five different diets for 12 weeks and the pancreas removed on the day they were killed. Rats fed a very low fat diet without ethanol (5% of total calories as lipid) developed malnutrition, pancreatic steatosis, and reduction in zymogen granules content. Animals fed a 35% lipid diet with ethanol also developed pancreatic steatosis but changes in zymogen granules content were not detected. Both malnutrition and longterm ethanol consumption increased pancreatic cholesterol ester content, and their effects were additive. Pancreatic steatosis was accompanied with hypercholesterolaemia. Amylase, lipase, and cholesterol esterase content were reduced in malnourished rats; but longterm ethanol ingestion, regardless of the nutritional state, increased lipase content and decreased amylase. It is suggested that high serum cholesterol concentrations and increased pancreatic lipase activity could cause accumulation of cholesterol esters in acinar cells. Fat accumulation in the pancreas has been reported as the earliest histopathological feature in alcoholic patients and may be responsible for cytotoxic effects on the acinar cells at the level of the cell membrane. Although it is difficult to extrapolate results in this animal study to the human situation, the results presented in this work might explain the higher incidence of pancreatitis is malnourished populations as well as in alcoholic subjects that is reported in dietary surveys. |
| publishDate |
1996 |
| dc.date.none.fl_str_mv |
1996 2011 2011 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/18622 |
| url |
https://hdl.handle.net/2445/18622 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.38.2.285 Gut, 1996, vol. 38, núm. 2, p. 285-292 http://dx.doi.org/10.1136/gut.38.2.285 |
| dc.rights.none.fl_str_mv |
(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1996 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1996 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
8 p. application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
BMJ Group |
| publisher.none.fl_str_mv |
BMJ Group |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Fonaments Clínics) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869405058401042432 |
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15,81155 |