Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome

We aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED-Plus study with 152 males and...

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Autores: Ruiz-Limón, P, Muralidharan, J, Gomez-Perez, AM, Murri, M, Vioque, J, Corella, D, Fito, M, Vidal, J, Salas-Salvadó, J, Torres-Collado, L, Coltell, O, Atzeni, A, Castañer, O, Bulló, M, Bernal-López, MR, Moreno-Indias, I, Tinahones, FJ
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p10140
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones10140
https://www.termedia.pl/Physical-activity-shifts-gut-microbiota-structure-in-aged-subjects-r-nwith-overweight-obesity-and-metabolic-syndrome,78,51833,0,1.html
Access Level:acceso abierto
Palavra-chave:Gut microbiota
Metabolic syndrome
Physical activity
Obesity
Overweight
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spelling Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndromeRuiz-Limón, PMuralidharan, JGomez-Perez, AMMurri, MVioque, JCorella, DFito, MVidal, JSalas-Salvadó, JTorres-Collado, LColtell, OAtzeni, ACastañer, OBulló, MBernal-López, MRMoreno-Indias, ITinahones, FJGut microbiotaMetabolic syndromePhysical activityObesityOverweightWe aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED-Plus study with 152 males and 145 females with overweight/obesity and metabolic syndrome. General assessments, anthropometric and biochemical measurements, and gut microbial 16S rRNA sequencing data were analyzed at baseline and 1-year of follow-up. Participants were stratified by tertiles of 1-year change in total PA-related energy expenditure ranging from -98.77 to 1099.99 METs (min/week). The total PA percentage of change was reduced in tertile 1 (-44.83 +/- 24.94), increased in tertile 2 (28.96 +/- 23.33) and tertile 3 (273.64 +/- 221.42). Beta diversity analysis showed differences in the gut microbiota population within each tertile group. Significant differences were found at phylum, family, and genus levels in the gut microbiota of the three tertile groups at baseline and 1-year timepoint. Tertile 3, the group with the greatest increase in PA, was characterized by increases in their levels of Sutterella, Bilophila, and Lachnospira bacteria as well as a reduction in Collinsella. Moreover, this tertile showed a different pattern in its predicted metabolic capacities to the other groups. Our results have microbiota profile. This modulation of gut microbiome populations and their metabolic capacities may contribute to the health of the aged individuals with overweight/obesity and metabolic syndrome.TERMEDIA PUBLISHING HOUSE LTD2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones10140https://www.termedia.pl/Physical-activity-shifts-gut-microbiota-structure-in-aged-subjects-r-nwith-overweight-obesity-and-metabolic-syndrome,78,51833,0,1.htmlBIOLOGY OF SPORTISSN: 0860021XISSNe: 20831862reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p101402026-06-12T10:20:37Z
dc.title.none.fl_str_mv Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
title Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
spellingShingle Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
Ruiz-Limón, P
Gut microbiota
Metabolic syndrome
Physical activity
Obesity
Overweight
title_short Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
title_full Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
title_fullStr Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
title_full_unstemmed Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
title_sort Physical activity shifts gut microbiota structure in aged subjects with overweight/obesity and metabolic syndrome
dc.creator.none.fl_str_mv Ruiz-Limón, P
Muralidharan, J
Gomez-Perez, AM
Murri, M
Vioque, J
Corella, D
Fito, M
Vidal, J
Salas-Salvadó, J
Torres-Collado, L
Coltell, O
Atzeni, A
Castañer, O
Bulló, M
Bernal-López, MR
Moreno-Indias, I
Tinahones, FJ
author Ruiz-Limón, P
author_facet Ruiz-Limón, P
Muralidharan, J
Gomez-Perez, AM
Murri, M
Vioque, J
Corella, D
Fito, M
Vidal, J
Salas-Salvadó, J
Torres-Collado, L
Coltell, O
Atzeni, A
Castañer, O
Bulló, M
Bernal-López, MR
Moreno-Indias, I
Tinahones, FJ
author_role author
author2 Muralidharan, J
Gomez-Perez, AM
Murri, M
Vioque, J
Corella, D
Fito, M
Vidal, J
Salas-Salvadó, J
Torres-Collado, L
Coltell, O
Atzeni, A
Castañer, O
Bulló, M
Bernal-López, MR
Moreno-Indias, I
Tinahones, FJ
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Gut microbiota
Metabolic syndrome
Physical activity
Obesity
Overweight
topic Gut microbiota
Metabolic syndrome
Physical activity
Obesity
Overweight
description We aimed to identify how physical activity (PA), within the context of a Mediterranean diet, affects metabolic variables and gut microbiota in older individuals with overweight/obesity and metabolic syndrome. Observational analysis was conducted as part of the PREDIMED-Plus study with 152 males and 145 females with overweight/obesity and metabolic syndrome. General assessments, anthropometric and biochemical measurements, and gut microbial 16S rRNA sequencing data were analyzed at baseline and 1-year of follow-up. Participants were stratified by tertiles of 1-year change in total PA-related energy expenditure ranging from -98.77 to 1099.99 METs (min/week). The total PA percentage of change was reduced in tertile 1 (-44.83 +/- 24.94), increased in tertile 2 (28.96 +/- 23.33) and tertile 3 (273.64 +/- 221.42). Beta diversity analysis showed differences in the gut microbiota population within each tertile group. Significant differences were found at phylum, family, and genus levels in the gut microbiota of the three tertile groups at baseline and 1-year timepoint. Tertile 3, the group with the greatest increase in PA, was characterized by increases in their levels of Sutterella, Bilophila, and Lachnospira bacteria as well as a reduction in Collinsella. Moreover, this tertile showed a different pattern in its predicted metabolic capacities to the other groups. Our results have microbiota profile. This modulation of gut microbiome populations and their metabolic capacities may contribute to the health of the aged individuals with overweight/obesity and metabolic syndrome.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones10140
https://www.termedia.pl/Physical-activity-shifts-gut-microbiota-structure-in-aged-subjects-r-nwith-overweight-obesity-and-metabolic-syndrome,78,51833,0,1.html
url https://isabial.portalinvestigacion.com/publicaciones10140
https://www.termedia.pl/Physical-activity-shifts-gut-microbiota-structure-in-aged-subjects-r-nwith-overweight-obesity-and-metabolic-syndrome,78,51833,0,1.html
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TERMEDIA PUBLISHING HOUSE LTD
publisher.none.fl_str_mv TERMEDIA PUBLISHING HOUSE LTD
dc.source.none.fl_str_mv BIOLOGY OF SPORT
ISSN: 0860021X
ISSNe: 20831862
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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