Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.

Detalles Bibliográficos
Autores: Vázquez Borsetti, Pablo Ernesto, Cortés, Roser, Artigas, Francesc
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/31671
Acceso en línea:http://hdl.handle.net/10261/31671
Access Level:acceso abierto
Palabra clave:Antipsychotics
Dopamine
Pyramidal neurons
Schizophrenia
Serotonin receptors
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spelling Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptorsVázquez Borsetti, Pablo ErnestoCortés, RoserArtigas, FrancescAntipsychoticsDopaminePyramidal neuronsSchizophreniaSerotonin receptorsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.The prefrontal cortex (PFC) is involved in higher brain functions altered in schizophrenia. Classical antipsychotics modulate corticolimbic circuits mainly through subcortical D2 receptor blockade, whereas second generation (atypical) antipsychotics preferentially target cortical 5-HT receptors. Anatomical and functional evidence supports a PFC-based control of the brainstem monoaminergic nuclei. Using a combination of retrograde tracing experiments and in situ hybridization we report that a substantial proportion of PFC pyramidal neurons projecting to the dorsal raphe (DR) and/or ventral tegmental area (VTA) express 5-HT2A receptors. Choleratoxin B application into the DR and the VTA retrogradely labeled projection neurons in the medial PFC (mPFC) and in orbitofrontal cortex (OFC). In situ hybridization of 5-HT2A receptor mRNA in the same tissue sections labeled a large neuronal population in mPFC and OFC. The percentage of DR-projecting neurons expressing 5-HT2A receptor mRNA was ~60% in mPFC and ~75% in OFC (n 5 3). Equivalent values for VTA-projecting neurons were ~55% in both mPFC and ventral OFC. Thus, 5-HT2A receptor activation/blockade in PFC may have downstream effects on dopaminergic and serotonergic systems via direct descending pathways. Atypical antipsychotics may distally modulate monoaminergic cells through PFC 5-HT2A receptor blockade, presumably decreasing the activity of neurons receiving direct cortical inputs.SAF grants (2004-05525 and 2007-62378); SENY Fundació; FPU predoctoral fellowship from the Spanish Ministry of Education to P.V.B. Funding to pay the Open Access publication charges for this article were provided by SENY Fundació.Peer reviewedOxford University Press201120112009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/31671reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1093/cercor/bhn204info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/316712026-05-22T06:33:51Z
dc.title.none.fl_str_mv Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
title Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
spellingShingle Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
Vázquez Borsetti, Pablo Ernesto
Antipsychotics
Dopamine
Pyramidal neurons
Schizophrenia
Serotonin receptors
title_short Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
title_full Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
title_fullStr Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
title_full_unstemmed Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
title_sort Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors
dc.creator.none.fl_str_mv Vázquez Borsetti, Pablo Ernesto
Cortés, Roser
Artigas, Francesc
author Vázquez Borsetti, Pablo Ernesto
author_facet Vázquez Borsetti, Pablo Ernesto
Cortés, Roser
Artigas, Francesc
author_role author
author2 Cortés, Roser
Artigas, Francesc
author2_role author
author
dc.subject.none.fl_str_mv Antipsychotics
Dopamine
Pyramidal neurons
Schizophrenia
Serotonin receptors
topic Antipsychotics
Dopamine
Pyramidal neurons
Schizophrenia
Serotonin receptors
description This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.
publishDate 2009
dc.date.none.fl_str_mv 2009
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/31671
url http://hdl.handle.net/10261/31671
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1093/cercor/bhn204
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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