Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C

Comunicación corta

Detalles Bibliográficos
Autores: Rivero-Juárez, Antonio, Mira, Jose A., Santos-Gil, Ignacio De Los, López Cortés, Luis Fernando, Girón-González, José-Antonio, Márquez, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:dnet:idus________::0ad686c2bf74131275b391b09e1bfb88
Acceso en línea:https://hdl.handle.net/11441/83506
https://doi.org/10.1089/aid.2012.0126
Access Level:acceso abierto
Palabra clave:Atazanavir
Hepatitis C
HIV Type 1
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spelling Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis CRivero-Juárez, AntonioMira, Jose A.Santos-Gil, Ignacio De LosLópez Cortés, Luis FernandoGirón-González, José-AntonioMárquez, ManuelAtazanavirHepatitis CHIV Type 1Comunicación cortaWe assessed the relationship between atazanavir (ATV)-based antiretroviral treatment (ART) and plasma hepatitis C virus (HCV) viral load in a population of HIV/HCV-coinfected patients. HIV/HCV-coinfected patients who received ART based on a protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI) were included. Patients were stratified by ART drug [ATV/rtv, lopinavir (LPV/rtv), efavirenz (EFV), nevirapine (NVP), and other PIs], HCV genotype (1/4 and 2/3), and IL28B genotype (CC and non-CC). The Kruskal-Wallis test and chi-squared test were used to compare continuous and categorical variables, respectively. Multivariate analysis consisted of a stepwise linear regression analysis. Six hundred and forty-nine HIV/HCV-coinfected patients were included. HCV genotype 1/4 patients who received ATV had higher HCV RNA levels [6.57 (5.9-6.8) log IU/ml] than those who received LPV [6.1 (5.5-6.5) log IU/ml], EFV [6.1 (5.6-6.4) log IU/ml], NVP [5.8 (5.5-5.9) log IU/ml], or other PIs [6.1 (5.7-6.4) log IU/ml] (p=0.014). This association held for the IL28B genotype (CC versus non-CC). The association was not found in patients carrying HCV genotypes 2/3. The linear regression model identified the IL28B genotype and ATV use as independent factors associated with HCV RNA levels. ATV-based therapy may be associated with a higher HCV RNA viral load in HIV/HCV-coinfected patients.MedicinaCTS-203: Estudio de las Enfermedades Infecciosas2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/83506https://doi.org/10.1089/aid.2012.0126reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)Inglésnullinfo:eu-repo/semantics/openAccessoai:dnet:idus________::0ad686c2bf74131275b391b09e1bfb882026-06-17T12:51:07Z
dc.title.none.fl_str_mv Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
title Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
spellingShingle Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
Rivero-Juárez, Antonio
Atazanavir
Hepatitis C
HIV Type 1
title_short Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
title_full Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
title_fullStr Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
title_full_unstemmed Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
title_sort Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C
dc.creator.none.fl_str_mv Rivero-Juárez, Antonio
Mira, Jose A.
Santos-Gil, Ignacio De Los
López Cortés, Luis Fernando
Girón-González, José-Antonio
Márquez, Manuel
author Rivero-Juárez, Antonio
author_facet Rivero-Juárez, Antonio
Mira, Jose A.
Santos-Gil, Ignacio De Los
López Cortés, Luis Fernando
Girón-González, José-Antonio
Márquez, Manuel
author_role author
author2 Mira, Jose A.
Santos-Gil, Ignacio De Los
López Cortés, Luis Fernando
Girón-González, José-Antonio
Márquez, Manuel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
CTS-203: Estudio de las Enfermedades Infecciosas
dc.subject.none.fl_str_mv Atazanavir
Hepatitis C
HIV Type 1
topic Atazanavir
Hepatitis C
HIV Type 1
description Comunicación corta
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/83506
https://doi.org/10.1089/aid.2012.0126
url https://hdl.handle.net/11441/83506
https://doi.org/10.1089/aid.2012.0126
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv null
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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