Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.

INTRODUCTION AND OBJECTIVES: Secondary prevention in myocardial infarction patients is paramount to prevent recurrences. Dual antiplatelet therapy has been shown to reduce the risk of subsequent events up to 1 year and beyond in the PEGASUS-TIMI 54 trial. This study aimed to estimate the annual numb...

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Autores: Marrugat de la Iglesia, Jaume, Elosua Llanos, Roberto, Sayols, Sergi, Dégano, Irene R.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/27112
Acesso em linha:http://hdl.handle.net/10230/27112
http://dx.doi.org/10.1016/j.rec.2015.12.022
Access Level:acceso abierto
Palavra-chave:Malalties coronàries
Diabetis
Infart de miocardi
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spelling Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.Marrugat de la Iglesia, JaumeElosua Llanos, RobertoSayols, SergiDégano, Irene R.Malalties coronàriesDiabetisInfart de miocardiINTRODUCTION AND OBJECTIVES: Secondary prevention in myocardial infarction patients is paramount to prevent recurrences. Dual antiplatelet therapy has been shown to reduce the risk of subsequent events up to 1 year and beyond in the PEGASUS-TIMI 54 trial. This study aimed to estimate the annual number of myocardial infarction patients with PEGASUS characteristics in Spain and to analyze short- and long-term outcomes in these patients. METHODS: The number of myocardial infarction patients was estimated assuming a Poisson distribution. Myocardial infarction incidence and mortality rates obtained from population registries (IBERICA and REGICOR) were properly adjusted. The proportion of myocardial infarction patients with PEGASUS characteristics was estimated with a REGICOR cohort of consecutive patients from 2003-2009 (n=1391). This cohort follow-up was used to compare the occurrence of reinfarction and death at 1 year and at the end of the follow-up (4.7 years) in patients with and without PEGASUS characteristics by Cox regression. RESULTS: The estimated annual number of stable myocardial infarction patients aged ≥ 50 years and without bleeding events was 41 311. Of these, 22 493 had at least 1 PEGASUS characteristic (diabetes, previous myocardial infarction, or chronic kidney disease). At 4.7 years of follow-up, having any PEGASUS characteristic or age ≥ 65 years was associated with a higher risk of cardiovascular and all-cause death in adjusted analyses (hazard ratio=3.44 and 2.21, 95% confidence interval, 1.22-9.74 and 1.11-4.42, respectively). CONCLUSIONS: In Spain, more than 50% of the stable myocardial infarction patients aged ≥ 50 years are estimated to have at least 1 PEGASUS characteristic, which substantially increases the long-term risk of cardiovascular and all-cause death.The REGICOR AMI Registry was supported by the Instituto de Salud Carlos III-FEDER (grant numbers RD06/0009, RD12/0042, FIS-90/0672, FIS-93/0568, FIS 94/0539, FIS96/0026-01, FIS99/0655, FIS99/0013-01, FIS 99/9342, PI081327, PI11/01801, CP12/03287 [MG], and IFI14/00007 [SSB]), the Catalan Agency for Management of University and Research Grants (grant numbers 2005SGR00577, 2009SGR1195, 2014SGR240), Fundació La Marató TV3 (grant number ID #081630) and Agència d’Informació, Avaluació i Qualitat en Salut (grant number AATRM 034/33/02). I.R. Dégano was funded by the RECERCAIXA Program, Obra Social ‘‘La Caixa’’ (grant number RE087465).Elsevier20162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/27112http://dx.doi.org/10.1016/j.rec.2015.12.022reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésRevista Española de Cardiología. 2016 May;69(5):480-7© Elsevier http://dx.doi.org/10.1016/j.rec.2015.12.022info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/271122026-06-12T07:21:37Z
dc.title.none.fl_str_mv Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
title Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
spellingShingle Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
Marrugat de la Iglesia, Jaume
Malalties coronàries
Diabetis
Infart de miocardi
title_short Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
title_full Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
title_fullStr Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
title_full_unstemmed Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
title_sort Prevalence and prognosis of high-risk myocardial infarction patient candidates to extended antiplatelet therapy.
dc.creator.none.fl_str_mv Marrugat de la Iglesia, Jaume
Elosua Llanos, Roberto
Sayols, Sergi
Dégano, Irene R.
author Marrugat de la Iglesia, Jaume
author_facet Marrugat de la Iglesia, Jaume
Elosua Llanos, Roberto
Sayols, Sergi
Dégano, Irene R.
author_role author
author2 Elosua Llanos, Roberto
Sayols, Sergi
Dégano, Irene R.
author2_role author
author
author
dc.subject.none.fl_str_mv Malalties coronàries
Diabetis
Infart de miocardi
topic Malalties coronàries
Diabetis
Infart de miocardi
description INTRODUCTION AND OBJECTIVES: Secondary prevention in myocardial infarction patients is paramount to prevent recurrences. Dual antiplatelet therapy has been shown to reduce the risk of subsequent events up to 1 year and beyond in the PEGASUS-TIMI 54 trial. This study aimed to estimate the annual number of myocardial infarction patients with PEGASUS characteristics in Spain and to analyze short- and long-term outcomes in these patients. METHODS: The number of myocardial infarction patients was estimated assuming a Poisson distribution. Myocardial infarction incidence and mortality rates obtained from population registries (IBERICA and REGICOR) were properly adjusted. The proportion of myocardial infarction patients with PEGASUS characteristics was estimated with a REGICOR cohort of consecutive patients from 2003-2009 (n=1391). This cohort follow-up was used to compare the occurrence of reinfarction and death at 1 year and at the end of the follow-up (4.7 years) in patients with and without PEGASUS characteristics by Cox regression. RESULTS: The estimated annual number of stable myocardial infarction patients aged ≥ 50 years and without bleeding events was 41 311. Of these, 22 493 had at least 1 PEGASUS characteristic (diabetes, previous myocardial infarction, or chronic kidney disease). At 4.7 years of follow-up, having any PEGASUS characteristic or age ≥ 65 years was associated with a higher risk of cardiovascular and all-cause death in adjusted analyses (hazard ratio=3.44 and 2.21, 95% confidence interval, 1.22-9.74 and 1.11-4.42, respectively). CONCLUSIONS: In Spain, more than 50% of the stable myocardial infarction patients aged ≥ 50 years are estimated to have at least 1 PEGASUS characteristic, which substantially increases the long-term risk of cardiovascular and all-cause death.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/27112
http://dx.doi.org/10.1016/j.rec.2015.12.022
url http://hdl.handle.net/10230/27112
http://dx.doi.org/10.1016/j.rec.2015.12.022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Revista Española de Cardiología. 2016 May;69(5):480-7
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.rec.2015.12.022
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.rec.2015.12.022
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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