Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit

The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level of neurotransmission. Here, we show that cholinergic...

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Detalles Bibliográficos
Autores: Velasco, Cecilia D., Llobet Berenguer, Artur, 1972-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/166423
Acceso en línea:https://hdl.handle.net/2445/166423
Access Level:acceso abierto
Palabra clave:Sinapsi
Cèl·lules
Neurociències
Synapses
Cells
Neurosciences
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spelling Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuitVelasco, Cecilia D.Llobet Berenguer, Artur, 1972-SinapsiCèl·lulesNeurociènciesSynapsesCellsNeurosciencesThe number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level of neurotransmission. Here, we show that cholinergic neurons grown in an autaptic circuit in the absence of glia sense the loss of half of their synaptic contacts triggered by exposure to peptide p4.2, a C-terminal fragment of SPARC. Synaptic elimination is driven by a reorganization of the periodic F-actin cytoskeleton present along neurites, and occurs without altering the density of postsynaptic receptors. Neurons recover baseline neurotransmission through a homeostatic presynaptic response that consists of the coordinated activation of rapid synapse formation and an overall potentiation of presynaptic calcium influx. These results demonstrate that neurons establishing autaptic connections continuously sense and adjust their synaptic output by tweaking the number of functional contacts and neurotransmitter release probability.Nature Publishing Group2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/166423Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s42003-020-0963-8Communications Biology, 2020, vol. 3, num. 1, p. 260https://doi.org/10.1038/s42003-020-0963-8cc-by (c) Velasco, Cecilia D. et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1664232026-05-27T06:46:51Z
dc.title.none.fl_str_mv Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
title Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
spellingShingle Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
Velasco, Cecilia D.
Sinapsi
Cèl·lules
Neurociències
Synapses
Cells
Neurosciences
title_short Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
title_full Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
title_fullStr Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
title_full_unstemmed Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
title_sort Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit
dc.creator.none.fl_str_mv Velasco, Cecilia D.
Llobet Berenguer, Artur, 1972-
author Velasco, Cecilia D.
author_facet Velasco, Cecilia D.
Llobet Berenguer, Artur, 1972-
author_role author
author2 Llobet Berenguer, Artur, 1972-
author2_role author
dc.subject.none.fl_str_mv Sinapsi
Cèl·lules
Neurociències
Synapses
Cells
Neurosciences
topic Sinapsi
Cèl·lules
Neurociències
Synapses
Cells
Neurosciences
description The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level of neurotransmission. Here, we show that cholinergic neurons grown in an autaptic circuit in the absence of glia sense the loss of half of their synaptic contacts triggered by exposure to peptide p4.2, a C-terminal fragment of SPARC. Synaptic elimination is driven by a reorganization of the periodic F-actin cytoskeleton present along neurites, and occurs without altering the density of postsynaptic receptors. Neurons recover baseline neurotransmission through a homeostatic presynaptic response that consists of the coordinated activation of rapid synapse formation and an overall potentiation of presynaptic calcium influx. These results demonstrate that neurons establishing autaptic connections continuously sense and adjust their synaptic output by tweaking the number of functional contacts and neurotransmitter release probability.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/166423
url https://hdl.handle.net/2445/166423
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s42003-020-0963-8
Communications Biology, 2020, vol. 3, num. 1, p. 260
https://doi.org/10.1038/s42003-020-0963-8
dc.rights.none.fl_str_mv cc-by (c) Velasco, Cecilia D. et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Velasco, Cecilia D. et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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