HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.

OBJECTIVES: Few studies have assessed cognitive impairment among healthy people living with HIV (PLWH) who are stable on antiretroviral treatment (ART) in sub-Saharan Africa. METHODS: We conducted a cross-sectional study among a random sample of stable adult PLWH from rural Tanzania on ART for more...

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Autores: Sanmartí M, Meyer AC, Jaen A, Robertson K, Tan N, Mapesi H, Samson L, Ndaki R, Battegay M, Tanner M, Weisser M, Dalmau D, Letang E, KIULARCO Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p18504
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18504
Access Level:acceso abierto
Palabra clave:HIV
antiretroviral treatment
neurocognitive impairment
prevalence
rural
sub-Saharan Africa
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spelling HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.Sanmartí MMeyer ACJaen ARobertson KTan NMapesi HSamson LNdaki RBattegay MTanner MWeisser MDalmau DLetang EKIULARCO GroupHIVantiretroviral treatmentneurocognitive impairmentprevalenceruralsub-Saharan AfricaOBJECTIVES: Few studies have assessed cognitive impairment among healthy people living with HIV (PLWH) who are stable on antiretroviral treatment (ART) in sub-Saharan Africa. METHODS: We conducted a cross-sectional study among a random sample of stable adult PLWH from rural Tanzania on ART for more than 1 year and without immunological failure or pre-existing neurological disease. We evaluated the prevalence and risk factors for neurocognitive impairment (NCI), assessed through neuropsychological tests, functional and depression questionnaires and defined as a mean Z-score = -1 in two or more cognitive domains. RESULTS: Among 243 participants [median age = 44.3 years (interquartile range: 36-52] and 71% female] we found a rate of NCI of 19.3% (95% confidence interval: 14.8-24.8%). Memory and psychomotor domains demonstrated the highest impairment. Independent predictors of NCI were age and self-reported alcohol use. Other classical risk factors were not associated with HIV-associated NCI. CONCLUSION: Despite effective ART roll-out, NCI remained a prevalent condition in this healthy rural Tanzanian population of PLWH on ART. Age and alcohol use were key risk factors.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18504HIV MEDICINEISSN: 14642662ISSNe: 14681293reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p185042026-05-27T12:37:41Z
dc.title.none.fl_str_mv HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
title HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
spellingShingle HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
Sanmartí M
HIV
antiretroviral treatment
neurocognitive impairment
prevalence
rural
sub-Saharan Africa
title_short HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
title_full HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
title_fullStr HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
title_full_unstemmed HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
title_sort HIV-associated neurocognitive impairment in stable people living with HIV on ART in rural Tanzania.
dc.creator.none.fl_str_mv Sanmartí M
Meyer AC
Jaen A
Robertson K
Tan N
Mapesi H
Samson L
Ndaki R
Battegay M
Tanner M
Weisser M
Dalmau D
Letang E
KIULARCO Group
author Sanmartí M
author_facet Sanmartí M
Meyer AC
Jaen A
Robertson K
Tan N
Mapesi H
Samson L
Ndaki R
Battegay M
Tanner M
Weisser M
Dalmau D
Letang E
KIULARCO Group
author_role author
author2 Meyer AC
Jaen A
Robertson K
Tan N
Mapesi H
Samson L
Ndaki R
Battegay M
Tanner M
Weisser M
Dalmau D
Letang E
KIULARCO Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HIV
antiretroviral treatment
neurocognitive impairment
prevalence
rural
sub-Saharan Africa
topic HIV
antiretroviral treatment
neurocognitive impairment
prevalence
rural
sub-Saharan Africa
description OBJECTIVES: Few studies have assessed cognitive impairment among healthy people living with HIV (PLWH) who are stable on antiretroviral treatment (ART) in sub-Saharan Africa. METHODS: We conducted a cross-sectional study among a random sample of stable adult PLWH from rural Tanzania on ART for more than 1 year and without immunological failure or pre-existing neurological disease. We evaluated the prevalence and risk factors for neurocognitive impairment (NCI), assessed through neuropsychological tests, functional and depression questionnaires and defined as a mean Z-score = -1 in two or more cognitive domains. RESULTS: Among 243 participants [median age = 44.3 years (interquartile range: 36-52] and 71% female] we found a rate of NCI of 19.3% (95% confidence interval: 14.8-24.8%). Memory and psychomotor domains demonstrated the highest impairment. Independent predictors of NCI were age and self-reported alcohol use. Other classical risk factors were not associated with HIV-associated NCI. CONCLUSION: Despite effective ART roll-out, NCI remained a prevalent condition in this healthy rural Tanzanian population of PLWH on ART. Age and alcohol use were key risk factors.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18504
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18504
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv HIV MEDICINE
ISSN: 14642662
ISSNe: 14681293
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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