Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles

TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficie...

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Bibliographic Details
Authors: Ruano, Jessica Louzame, Bejarano, Leire, Serrano, Rosa, Diaz, Ruth Alvarez, Flores Landeira, Juana María, López, Ana Cayuela, Blasco, Maria A.
Format: article
Publication Date:2025
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/125250
Online Access:https://hdl.handle.net/20.500.14352/125250
Access Level:Open access
Keyword:636.09
Trf1
Fat
Leaner
Metabolism
Telomeres
Veterinaria
3109 Ciencias Veterinarias
Description
Summary:TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism

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