2-Hydroxyethyl methacrylate (2-HEMA) sensitization, a global epidemic at its peak in Spain?

Background: A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives: To evaluate the frequency of sensitization to 2-hydroxyethyl methacrylate (2-HEMA) among consecutively patch tested patients with ecz...

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Detalhes bibliográficos
Autores: Gatica-Ortega, ME, Pastor-Nieto, MA, Giménez-Arnau, AM, Mercader-García, P, Sanz-Sánchez, T, Carrascosa-Carrillo, JM, Córdoba-Guijarro, S, Sánchez-Pérez, J, Silvestre, JF, Frutos, FJOD, Tous-Romero, F, Fernández-Redondo, V, Serra-Baldrich, E, Ruíz-González, I, Pérez, RG, Miquel-Miquel, J, Guillén, PSP, Hervella-García, M, Heras-Mendaza, F, Gómez-de-la-Fuente, E, Zaragoza-Ninet, V, Gilo, AS, Rodríguez-Serna, M, Melé-Ninot, G, Descalzo, MA, de-Vega, M, García-Doval, I, Borrego, L
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16705
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/16705
Access Level:acceso abierto
Palavra-chave:(meth)acrylates
2-hydroxyethyl methacrylate
acrylates
acrylic nails
allergic contact dermatitis
beauticians
occupational
patch test
prevalence
semi-permanent nail polish
Descrição
Resumo:Background: A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives: To evaluate the frequency of sensitization to 2-hydroxyethyl methacrylate (2-HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates. Methods: From January 2019 to December 2022, 2-HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres. ResultsSix thousand one hundred thirty-four patients were consecutively patch tested with 2-HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable 'occupational' was found to be significantly associated with a higher risk for relevant positive reactions to 2-HEMA (OR: 10.9; 95% CI: 8.1-14.9). Conclusion: (Meth)acrylate sensitization is a prevalent health issue in Spain. 2-HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.

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