An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples

new microfluidic device to enhance the enrichment factor in miniaturized systems is proposed. The microfluidic system was design for liquid phase microextractions, and it was applied to the simultaneous extraction of acidic compounds of a wide range of polarity (0.5 < log P < 3). The device op...

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Autores: Martín, Alejandro, Fernández Torres, Rut, Bello López, Miguel Ángel, Ramos Payán, María Dolores
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/156908
Acceso en línea:https://hdl.handle.net/11441/156908
https://doi.org/10.1007/s00604-023-05752-9
Access Level:acceso abierto
Palabra clave:Acidic drugs
Liquid phase microextraction
Microfluidic
Sample treatment
Supported liquid membrane
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spelling An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological SamplesMartín, AlejandroFernández Torres, RutBello López, Miguel ÁngelRamos Payán, María DoloresAcidic drugsLiquid phase microextractionMicrofluidicSample treatmentSupported liquid membranenew microfluidic device to enhance the enrichment factor in miniaturized systems is proposed. The microfluidic system was design for liquid phase microextractions, and it was applied to the simultaneous extraction of acidic compounds of a wide range of polarity (0.5 < log P < 3). The device operated under stagnant acceptor phase conditions and all the operational parameters involved were optimized. Tributyl phosphate was found to be a new highly efficient supported liquid membrane to simultaneously extract analytes of very different polarities. The optimal donor and acceptor phase were pH 2 and pH 13, respectively. The donor flow rate and the extraction time were investigated simultaneously, offering great versatility with high enrichment factors (EFs). Limits of quantitation were within 0.02 and 0.09 µg mL−1 for all compounds at 10 µL min−1 as donor flow rate and 20-min extractions, offering EFs between 11 and 18 with only 200-µL sample volume consumption. The method was successfully applied to human urine samples, observing recoveries between 47 and 90% for all compounds. This new proposed microfluidic system increases the wide range of applications, especially when the analytes are present in lower concentrations in the sample.Ministerio de Ciencia e Innovación PID2021-123073NB-C22Springer NatureQuímica AnalíticaMinisterio de Ciencia e Innovación (MICIN). España2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/156908https://doi.org/10.1007/s00604-023-05752-9reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésMicrochimica Acta, 190 (5), 170.PID2021-123073NB-C22https://doi.org/10.1007/s00604-023-05752-9info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1569082026-06-17T12:51:07Z
dc.title.none.fl_str_mv An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
title An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
spellingShingle An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
Martín, Alejandro
Acidic drugs
Liquid phase microextraction
Microfluidic
Sample treatment
Supported liquid membrane
title_short An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
title_full An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
title_fullStr An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
title_full_unstemmed An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
title_sort An Improved Microfluidic Device to Enhance the Enrichment Factors in Liquid Phase Microextraction: Application to the Simultaneous Extraction of Polar and Non-polar Acids in Biological Samples
dc.creator.none.fl_str_mv Martín, Alejandro
Fernández Torres, Rut
Bello López, Miguel Ángel
Ramos Payán, María Dolores
author Martín, Alejandro
author_facet Martín, Alejandro
Fernández Torres, Rut
Bello López, Miguel Ángel
Ramos Payán, María Dolores
author_role author
author2 Fernández Torres, Rut
Bello López, Miguel Ángel
Ramos Payán, María Dolores
author2_role author
author
author
dc.contributor.none.fl_str_mv Química Analítica
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv Acidic drugs
Liquid phase microextraction
Microfluidic
Sample treatment
Supported liquid membrane
topic Acidic drugs
Liquid phase microextraction
Microfluidic
Sample treatment
Supported liquid membrane
description new microfluidic device to enhance the enrichment factor in miniaturized systems is proposed. The microfluidic system was design for liquid phase microextractions, and it was applied to the simultaneous extraction of acidic compounds of a wide range of polarity (0.5 < log P < 3). The device operated under stagnant acceptor phase conditions and all the operational parameters involved were optimized. Tributyl phosphate was found to be a new highly efficient supported liquid membrane to simultaneously extract analytes of very different polarities. The optimal donor and acceptor phase were pH 2 and pH 13, respectively. The donor flow rate and the extraction time were investigated simultaneously, offering great versatility with high enrichment factors (EFs). Limits of quantitation were within 0.02 and 0.09 µg mL−1 for all compounds at 10 µL min−1 as donor flow rate and 20-min extractions, offering EFs between 11 and 18 with only 200-µL sample volume consumption. The method was successfully applied to human urine samples, observing recoveries between 47 and 90% for all compounds. This new proposed microfluidic system increases the wide range of applications, especially when the analytes are present in lower concentrations in the sample.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/156908
https://doi.org/10.1007/s00604-023-05752-9
url https://hdl.handle.net/11441/156908
https://doi.org/10.1007/s00604-023-05752-9
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Microchimica Acta, 190 (5), 170.
PID2021-123073NB-C22
https://doi.org/10.1007/s00604-023-05752-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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