Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs

Background: The adenoma detection rate (ADR) is the main quality indicator of colonoscopy. The ADR recommended in fecal immunochemical testing (FIT)-based colorectal cancer screening programs is unknown. Methods: Using the COLONPREV (NCT00906997) study dataset, we performed a post-hoc analysis to de...

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Autores: Cubiella, Joaquin, Castells, Antoni, Andreu, Montserrat, Bujanda, Luis, Carballo, Fernando, JOVER, R., Lanas, Angel, Diego Morillas, Juan, Salas, Dolores, Quintero, Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p1955
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/1955
Access Level:acceso abierto
Palabra clave:Colorectal adenoma
colorectal neoplasm
fecal immunochemical test
colonoscopy
colorectal cancer screening
adenoma detection rate
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spelling Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programsCubiella, JoaquinCastells, AntoniAndreu, MontserratBujanda, LuisCarballo, FernandoJOVER, R.Lanas, AngelDiego Morillas, JuanSalas, DoloresQuintero, EnriqueColorectal adenomacolorectal neoplasmfecal immunochemical testcolonoscopycolorectal cancer screeningadenoma detection rateBackground: The adenoma detection rate (ADR) is the main quality indicator of colonoscopy. The ADR recommended in fecal immunochemical testing (FIT)-based colorectal cancer screening programs is unknown. Methods: Using the COLONPREV (NCT00906997) study dataset, we performed a post-hoc analysis to determine if there was a correlation between the ADR in primary and work-up colonoscopy, and the equivalent figure to the minimal 20% ADR recommended. Colonoscopy was performed in 5722 individuals: 5059 as primary strategy and 663 after a positive FIT result (OC-Sensor (TM); cut-off level 15 mu g/g of feces). We developed a predictive model based on a multivariable lineal regression analysis including confounding variables. Results: The median ADR was 31% (range, 14%-51%) in the colonoscopy group and 55% (range, 21%-83%) in the FIT group. There was a positive correlation in the ADR between primary and work-up colonoscopy (Pearson's coefficient 0.716; p<0.001). ADR in the FIT group was independently related to ADR in the colonoscopy group: regression coefficient for colonoscopy ADR, 0.71 (p=0.009); sex, 0.09 (p=0.09); age, 0.3 (p=0.5); and region 0.00 (p=0.9). The equivalent figure to the 20% ADR was 45% (95% confidence interval, 35%-56%). Conclusions: ADR in primary and work-up colonoscopy of a FIT-positive result are positively and significantly correlated.JOHN WILEY & SONS LTD2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/1955United European Gastroenterology JournalISSN: 20506406ISSNe: 20506414reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p19552026-06-11T12:45:17Z
dc.title.none.fl_str_mv Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
title Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
spellingShingle Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
Cubiella, Joaquin
Colorectal adenoma
colorectal neoplasm
fecal immunochemical test
colonoscopy
colorectal cancer screening
adenoma detection rate
title_short Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
title_full Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
title_fullStr Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
title_full_unstemmed Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
title_sort Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs
dc.creator.none.fl_str_mv Cubiella, Joaquin
Castells, Antoni
Andreu, Montserrat
Bujanda, Luis
Carballo, Fernando
JOVER, R.
Lanas, Angel
Diego Morillas, Juan
Salas, Dolores
Quintero, Enrique
author Cubiella, Joaquin
author_facet Cubiella, Joaquin
Castells, Antoni
Andreu, Montserrat
Bujanda, Luis
Carballo, Fernando
JOVER, R.
Lanas, Angel
Diego Morillas, Juan
Salas, Dolores
Quintero, Enrique
author_role author
author2 Castells, Antoni
Andreu, Montserrat
Bujanda, Luis
Carballo, Fernando
JOVER, R.
Lanas, Angel
Diego Morillas, Juan
Salas, Dolores
Quintero, Enrique
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Colorectal adenoma
colorectal neoplasm
fecal immunochemical test
colonoscopy
colorectal cancer screening
adenoma detection rate
topic Colorectal adenoma
colorectal neoplasm
fecal immunochemical test
colonoscopy
colorectal cancer screening
adenoma detection rate
description Background: The adenoma detection rate (ADR) is the main quality indicator of colonoscopy. The ADR recommended in fecal immunochemical testing (FIT)-based colorectal cancer screening programs is unknown. Methods: Using the COLONPREV (NCT00906997) study dataset, we performed a post-hoc analysis to determine if there was a correlation between the ADR in primary and work-up colonoscopy, and the equivalent figure to the minimal 20% ADR recommended. Colonoscopy was performed in 5722 individuals: 5059 as primary strategy and 663 after a positive FIT result (OC-Sensor (TM); cut-off level 15 mu g/g of feces). We developed a predictive model based on a multivariable lineal regression analysis including confounding variables. Results: The median ADR was 31% (range, 14%-51%) in the colonoscopy group and 55% (range, 21%-83%) in the FIT group. There was a positive correlation in the ADR between primary and work-up colonoscopy (Pearson's coefficient 0.716; p<0.001). ADR in the FIT group was independently related to ADR in the colonoscopy group: regression coefficient for colonoscopy ADR, 0.71 (p=0.009); sex, 0.09 (p=0.09); age, 0.3 (p=0.5); and region 0.00 (p=0.9). The equivalent figure to the 20% ADR was 45% (95% confidence interval, 35%-56%). Conclusions: ADR in primary and work-up colonoscopy of a FIT-positive result are positively and significantly correlated.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/1955
url https://fisabio.portalinvestigacion.com/publicaciones/1955
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv JOHN WILEY & SONS LTD
publisher.none.fl_str_mv JOHN WILEY & SONS LTD
dc.source.none.fl_str_mv United European Gastroenterology Journal
ISSN: 20506406
ISSNe: 20506414
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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