Insulin and disorders of behavioural flexibility

Behavioural inflexibility is a symptom of neuropsychiatric and neurodegenerative disorders such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer's Disease, encompassing the maintenance of a behaviour even when no longer appropriate. Recent evidence suggests that insulin...

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Detalles Bibliográficos
Autores: Scholtz, Samantha, Glennon, Jeffrey C., Sullivan, Mairead, Fernández Aranda, Fernando, Camacho Barcia, Lucía, Harkin, Andrew, Macrì, Simone, Mora Maltas, Bernat, Jiménez-Murcia, Susana, O'Leary, Aet, Ottomana, Angela Maria, Presta, Martina, Slattery, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad Pontificia de Salamanca
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/224864
Acceso en línea:https://hdl.handle.net/2445/224864
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Animals
Autisme
Diabetis no-insulinodependent
Alzheimer's disease
Autism
Non-insulin-dependent diabetes
Descripción
Sumario:Behavioural inflexibility is a symptom of neuropsychiatric and neurodegenerative disorders such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer's Disease, encompassing the maintenance of a behaviour even when no longer appropriate. Recent evidence suggests that insulin signalling has roles apart from its regulation of peripheral metabolism and mediates behaviourally-relevant central nervous system (CNS) functions including behavioural flexibility. Indeed, insulin resistance is reported to generate anxious, perseverative phenotypes in animal models, with the Type 2 diabetes medication metformin proving to be beneficial for disorders including Alzheimer's Disease. Structural and functional neuroimaging studies of Type 2 diabetes patients have highlighted aberrant connectivity in regions governing salience detection, attention, inhibition and memory. As currently available therapeutic strategies feature high rates of resistance, there is an urgent need to better understand the complex aetiology of behaviour and develop improved therapeutics. In this review, we explore the circuitry underlying behavioural flexibility, changes in Type 2 diabetes, the role of insulin in CNS outcomes and mechanisms of insulin involvement across disorders of behavioural inflexibility.