Meteorin-like levels are associated with active brown adipose tissue in early infancy

Meteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues. It exerts multiple beneficial effects on metabolic and cardiovascular systems in experimental models. However, the potential role of METRNL as brown adipokine in...

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Autores: Garcia-Beltran, Cristina|||0000-0001-6720-7936, Navarro-Gascon, Artur|||0000-0002-3543-3880, López-Bermejo, Abel|||0000-0002-5828-8911, Quesada-López, Tania|||0000-0002-7818-4351, de Zegher, Francis|||0000-0002-2491-5884, Ibáñez, Lourdes|||0000-0003-4595-7191, Villarroya, Francesc|||0000-0003-1266-9142
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:302851
Acesso em linha:https://ddd.uab.cat/record/302851
https://dx.doi.org/urn:doi:10.3389/fendo.2023.1136245
Access Level:Acceso aberto
Palavra-chave:Brown adipokine
Brown adipose tissue (BAT)
Infancy
Meteorin-like (METRNL)
Thermogenesis
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spelling Meteorin-like levels are associated with active brown adipose tissue in early infancyGarcia-Beltran, Cristina|||0000-0001-6720-7936Navarro-Gascon, Artur|||0000-0002-3543-3880López-Bermejo, Abel|||0000-0002-5828-8911Quesada-López, Tania|||0000-0002-7818-4351de Zegher, Francis|||0000-0002-2491-5884Ibáñez, Lourdes|||0000-0003-4595-7191Villarroya, Francesc|||0000-0003-1266-9142Brown adipokineBrown adipose tissue (BAT)InfancyMeteorin-like (METRNL)ThermogenesisMeteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues. It exerts multiple beneficial effects on metabolic and cardiovascular systems in experimental models. However, the potential role of METRNL as brown adipokine in humans has not been investigated previously, particularly in relation to the metabolic adaptations taking place in early life, when brown adipose tissue (BAT) is particularly abundant. METRNL levels, as well as body composition (DXA) and circulating endocrine-metabolic variables, were assessed longitudinally in a cohort of infants at birth, and at ages 4 and 12 months. BAT activity was measured by infrared thermography at age 12 months. METRNL levels were also determined cross-sectionally in adults; METRNL gene expression (qRT-PCR) was assessed in BAT and liver samples from neonates, and in adipose tissue and liver samples form adults. Simpson-Golabi-Behmel Syndrome (SGBS) adipose cells were thermogenically activated using cAMP, and METRNL gene expression and METRNL protein released were analysed. Serum METRNL levels were high at birth and declined across the first year of life albeit remaining higher than in adulthood. At age 4 and 12 months, METRNL levels correlated positively with circulating C-X-C motif chemokine ligand 14 (CXCL14), a chemokine released by thermogenically active BAT, but not with parameters of adiposity or metabolic status. METRNL levels also correlated positively with infrared thermography-estimated posterior-cervical BAT activity in girls aged 12 months. Gene expression analysis indicated high levels of METRNL mRNA in neonatal BAT. Thermogenic stimulus of brown/beige adipocytes led to a significant increase of METRNL gene expression and METRN protein release to the cell culture medium. Circulating METRNL levels are high in the first year of life and correlate with indices of BAT activity and with levels of an established brown adipokine such as CXCL14. These data, in addition with the high expression of METRNL in neonatal BAT and in thermogenically-stimulated brown/beige adipocytes, suggest that METRNL is actively secreted by BAT and may be a circulating biomarker of BAT activity in early life.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302851https://dx.doi.org/urn:doi:10.3389/fendo.2023.1136245reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3028512026-06-06T12:50:31Z
dc.title.none.fl_str_mv Meteorin-like levels are associated with active brown adipose tissue in early infancy
title Meteorin-like levels are associated with active brown adipose tissue in early infancy
spellingShingle Meteorin-like levels are associated with active brown adipose tissue in early infancy
Garcia-Beltran, Cristina|||0000-0001-6720-7936
Brown adipokine
Brown adipose tissue (BAT)
Infancy
Meteorin-like (METRNL)
Thermogenesis
title_short Meteorin-like levels are associated with active brown adipose tissue in early infancy
title_full Meteorin-like levels are associated with active brown adipose tissue in early infancy
title_fullStr Meteorin-like levels are associated with active brown adipose tissue in early infancy
title_full_unstemmed Meteorin-like levels are associated with active brown adipose tissue in early infancy
title_sort Meteorin-like levels are associated with active brown adipose tissue in early infancy
dc.creator.none.fl_str_mv Garcia-Beltran, Cristina|||0000-0001-6720-7936
Navarro-Gascon, Artur|||0000-0002-3543-3880
López-Bermejo, Abel|||0000-0002-5828-8911
Quesada-López, Tania|||0000-0002-7818-4351
de Zegher, Francis|||0000-0002-2491-5884
Ibáñez, Lourdes|||0000-0003-4595-7191
Villarroya, Francesc|||0000-0003-1266-9142
author Garcia-Beltran, Cristina|||0000-0001-6720-7936
author_facet Garcia-Beltran, Cristina|||0000-0001-6720-7936
Navarro-Gascon, Artur|||0000-0002-3543-3880
López-Bermejo, Abel|||0000-0002-5828-8911
Quesada-López, Tania|||0000-0002-7818-4351
de Zegher, Francis|||0000-0002-2491-5884
Ibáñez, Lourdes|||0000-0003-4595-7191
Villarroya, Francesc|||0000-0003-1266-9142
author_role author
author2 Navarro-Gascon, Artur|||0000-0002-3543-3880
López-Bermejo, Abel|||0000-0002-5828-8911
Quesada-López, Tania|||0000-0002-7818-4351
de Zegher, Francis|||0000-0002-2491-5884
Ibáñez, Lourdes|||0000-0003-4595-7191
Villarroya, Francesc|||0000-0003-1266-9142
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Brown adipokine
Brown adipose tissue (BAT)
Infancy
Meteorin-like (METRNL)
Thermogenesis
topic Brown adipokine
Brown adipose tissue (BAT)
Infancy
Meteorin-like (METRNL)
Thermogenesis
description Meteorin-like (METRNL) is a hormonal factor released by several tissues, including thermogenically active brown and beige adipose tissues. It exerts multiple beneficial effects on metabolic and cardiovascular systems in experimental models. However, the potential role of METRNL as brown adipokine in humans has not been investigated previously, particularly in relation to the metabolic adaptations taking place in early life, when brown adipose tissue (BAT) is particularly abundant. METRNL levels, as well as body composition (DXA) and circulating endocrine-metabolic variables, were assessed longitudinally in a cohort of infants at birth, and at ages 4 and 12 months. BAT activity was measured by infrared thermography at age 12 months. METRNL levels were also determined cross-sectionally in adults; METRNL gene expression (qRT-PCR) was assessed in BAT and liver samples from neonates, and in adipose tissue and liver samples form adults. Simpson-Golabi-Behmel Syndrome (SGBS) adipose cells were thermogenically activated using cAMP, and METRNL gene expression and METRNL protein released were analysed. Serum METRNL levels were high at birth and declined across the first year of life albeit remaining higher than in adulthood. At age 4 and 12 months, METRNL levels correlated positively with circulating C-X-C motif chemokine ligand 14 (CXCL14), a chemokine released by thermogenically active BAT, but not with parameters of adiposity or metabolic status. METRNL levels also correlated positively with infrared thermography-estimated posterior-cervical BAT activity in girls aged 12 months. Gene expression analysis indicated high levels of METRNL mRNA in neonatal BAT. Thermogenic stimulus of brown/beige adipocytes led to a significant increase of METRNL gene expression and METRN protein release to the cell culture medium. Circulating METRNL levels are high in the first year of life and correlate with indices of BAT activity and with levels of an established brown adipokine such as CXCL14. These data, in addition with the high expression of METRNL in neonatal BAT and in thermogenically-stimulated brown/beige adipocytes, suggest that METRNL is actively secreted by BAT and may be a circulating biomarker of BAT activity in early life.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/302851
https://dx.doi.org/urn:doi:10.3389/fendo.2023.1136245
url https://ddd.uab.cat/record/302851
https://dx.doi.org/urn:doi:10.3389/fendo.2023.1136245
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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