Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease

Purpose of review: The goal is to review the connection between gut microbiota and cardiovascular disease, with specific emphasis on bile acids, and the influence of diet in modulating this relationship. Recent findings: Bile acids exert a much broader range of biological functions than initially re...

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Detalhes bibliográficos
Autores: Rodríguez-Morató, Jose, 1987-, Matthan, Nirupa R.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/52424
Acesso em linha:http://hdl.handle.net/10230/52424
http://dx.doi.org/10.1007/s11883-020-00863-7
Access Level:acceso abierto
Palavra-chave:Bile acids
Cardiometabolic risk factors
Cardiovascular disease
Diet
Gut microbiota
Metabolism
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spelling Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular diseaseRodríguez-Morató, Jose, 1987-Matthan, Nirupa R.Bile acidsCardiometabolic risk factorsCardiovascular diseaseDietGut microbiotaMetabolismPurpose of review: The goal is to review the connection between gut microbiota and cardiovascular disease, with specific emphasis on bile acids, and the influence of diet in modulating this relationship. Recent findings: Bile acids exert a much broader range of biological functions than initially recognized, including regulation of cardiovascular function through direct and indirect mechanisms. There is a bi-directional relationship between gut microbiota modulation of bile acid-signaling properties, and their effects on gut microbiota composition. Evidence, primarily from rodent models and limited human trials, suggest that dietary modulation of the gut microbiome significantly impacts bile acid metabolism and subsequently host physiological response(s). Available evidence suggests that the link between diet, gut microbiota, and CVD risk is potentially mediated via bile acid effects on diverse metabolic pathways. However, further studies are needed to confirm/expand and translate these findings in a clinical setting.Springer202220222020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52424http://dx.doi.org/10.1007/s11883-020-00863-7reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCurr Atheroscler Rep. 2020;22(9):47info:eu-repo/grantAgreement/EC/H2020/712949© Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s11883-020-00863-7.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/524242026-06-12T07:21:37Z
dc.title.none.fl_str_mv Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
title Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
spellingShingle Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
Rodríguez-Morató, Jose, 1987-
Bile acids
Cardiometabolic risk factors
Cardiovascular disease
Diet
Gut microbiota
Metabolism
title_short Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
title_full Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
title_fullStr Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
title_full_unstemmed Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
title_sort Nutrition and gastrointestinal microbiota, microbial-derived secondary bile acids, and cardiovascular disease
dc.creator.none.fl_str_mv Rodríguez-Morató, Jose, 1987-
Matthan, Nirupa R.
author Rodríguez-Morató, Jose, 1987-
author_facet Rodríguez-Morató, Jose, 1987-
Matthan, Nirupa R.
author_role author
author2 Matthan, Nirupa R.
author2_role author
dc.subject.none.fl_str_mv Bile acids
Cardiometabolic risk factors
Cardiovascular disease
Diet
Gut microbiota
Metabolism
topic Bile acids
Cardiometabolic risk factors
Cardiovascular disease
Diet
Gut microbiota
Metabolism
description Purpose of review: The goal is to review the connection between gut microbiota and cardiovascular disease, with specific emphasis on bile acids, and the influence of diet in modulating this relationship. Recent findings: Bile acids exert a much broader range of biological functions than initially recognized, including regulation of cardiovascular function through direct and indirect mechanisms. There is a bi-directional relationship between gut microbiota modulation of bile acid-signaling properties, and their effects on gut microbiota composition. Evidence, primarily from rodent models and limited human trials, suggest that dietary modulation of the gut microbiome significantly impacts bile acid metabolism and subsequently host physiological response(s). Available evidence suggests that the link between diet, gut microbiota, and CVD risk is potentially mediated via bile acid effects on diverse metabolic pathways. However, further studies are needed to confirm/expand and translate these findings in a clinical setting.
publishDate 2020
dc.date.none.fl_str_mv 2020
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52424
http://dx.doi.org/10.1007/s11883-020-00863-7
url http://hdl.handle.net/10230/52424
http://dx.doi.org/10.1007/s11883-020-00863-7
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Curr Atheroscler Rep. 2020;22(9):47
info:eu-repo/grantAgreement/EC/H2020/712949
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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