Mycobacterium tuberculosis complex in domestic goats in Southern Spain

Tuberculosis (TB) is a zoonotic infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTC), which can affect a wide variety of domestic and wild animal species. Although the role of goats as a reservoir of MTC bacteria has been evidenced, information about the ci...

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Autores: Jiménez-Martín, Débora, García-Bocanegra, Ignacio, Risalde, María A, Napp, Sebastián, Dominguez-Rodriguez, Mercedes, Romero, Beatriz, Moreno-Iruela, Inmaculada, Martínez, Remigio, Cano-Terriza, David
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/19924
Acceso en línea:http://hdl.handle.net/20.500.12105/19924
Access Level:acceso abierto
Palabra clave:Goats
Goat Diseases
Tuberculosis
Mycobacterium tuberculosis
Animals
Spain
Seroepidemiologic Studies
Risk Factors
Female
Enzyme-Linked Immunosorbent Assay
Male
Prevalence
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spelling Mycobacterium tuberculosis complex in domestic goats in Southern SpainJiménez-Martín, DéboraGarcía-Bocanegra, IgnacioRisalde, María ANapp, SebastiánDominguez-Rodriguez, MercedesRomero, BeatrizMoreno-Iruela, InmaculadaMartínez, RemigioCano-Terriza, DavidGoatsGoat DiseasesTuberculosisMycobacterium tuberculosisAnimalsSpainSeroepidemiologic StudiesRisk FactorsFemaleEnzyme-Linked Immunosorbent AssayMalePrevalenceTuberculosis (TB) is a zoonotic infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTC), which can affect a wide variety of domestic and wild animal species. Although the role of goats as a reservoir of MTC bacteria has been evidenced, information about the circulation of MTC strains in this species is still very scarce. The aim of the present study was to determine the seroprevalence, spatial distribution, risk factors and MTC spoligotypes circulating in goats from Andalusia (Southern Spain), the Spanish region with the largest goat census and a hotspot area of TB in both cattle and wild ungulates. A total of 2155 serum samples from 80 goat flocks were analyzed by an in-house ELISA using the P22 protein complex as a coating antigen. Antibodies against MTC were detected in 473 goats (21.9%, 95% CI: 20.2-23.7) and the true seroprevalence was 22.3% (95% CI: 20.6-24.1). Seropositivity was found in 72 (90.0%) of the 80 flocks analyzed. The generalized estimating equation model showed that the management system (higher seroprevalence on intensive and semi-intensive farms), and the presence of hospital pens inside the regular stables, were risk factors potentially associated with MTC exposure in goats in Southern Spain. The spatial analysis identified a significant spatial cluster (p < 0.001) in Eastern Andalusia. A total of 16 different MTC spoligotypes, including five of M. caprae and eleven of M. bovis, were identified in goats between 2015 and 2022 in the study area, with SB0157 as the most frequently isolated. The results obtained indicate widespread and non-homogeneous spatial distribution of MTC in goat herds from Southern Spain. The high individual and herd-level seroprevalence values found suggest that goats could play a significant role in the maintenance and transmission of MTC in the study area. Our results highlight the importance of implementing control measures in this species.ElsevierMinisterio de Agricultura, Pesca y Alimentación (España)Ministerio de Economía y Competitividad (España)University of Córdoba (España)Ministerio de Ciencia e Innovación (España)Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Ministerio de Universidades (España)Regional Government of Andalusia (España)Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)20242024-07-0320242024-06-0120242024-06-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/19924reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEC UCO-FEDER-1381385-R Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/199242026-06-12T12:43:37Z
dc.title.none.fl_str_mv Mycobacterium tuberculosis complex in domestic goats in Southern Spain
title Mycobacterium tuberculosis complex in domestic goats in Southern Spain
spellingShingle Mycobacterium tuberculosis complex in domestic goats in Southern Spain
Jiménez-Martín, Débora
Goats
Goat Diseases
Tuberculosis
Mycobacterium tuberculosis
Animals
Spain
Seroepidemiologic Studies
Risk Factors
Female
Enzyme-Linked Immunosorbent Assay
Male
Prevalence
title_short Mycobacterium tuberculosis complex in domestic goats in Southern Spain
title_full Mycobacterium tuberculosis complex in domestic goats in Southern Spain
title_fullStr Mycobacterium tuberculosis complex in domestic goats in Southern Spain
title_full_unstemmed Mycobacterium tuberculosis complex in domestic goats in Southern Spain
title_sort Mycobacterium tuberculosis complex in domestic goats in Southern Spain
dc.creator.none.fl_str_mv Jiménez-Martín, Débora
García-Bocanegra, Ignacio
Risalde, María A
Napp, Sebastián
Dominguez-Rodriguez, Mercedes
Romero, Beatriz
Moreno-Iruela, Inmaculada
Martínez, Remigio
Cano-Terriza, David
author Jiménez-Martín, Débora
author_facet Jiménez-Martín, Débora
García-Bocanegra, Ignacio
Risalde, María A
Napp, Sebastián
Dominguez-Rodriguez, Mercedes
Romero, Beatriz
Moreno-Iruela, Inmaculada
Martínez, Remigio
Cano-Terriza, David
author_role author
author2 García-Bocanegra, Ignacio
Risalde, María A
Napp, Sebastián
Dominguez-Rodriguez, Mercedes
Romero, Beatriz
Moreno-Iruela, Inmaculada
Martínez, Remigio
Cano-Terriza, David
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Agricultura, Pesca y Alimentación (España)
Ministerio de Economía y Competitividad (España)
University of Córdoba (España)
Ministerio de Ciencia e Innovación (España)
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Ministerio de Universidades (España)
Regional Government of Andalusia (España)
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
dc.subject.none.fl_str_mv Goats
Goat Diseases
Tuberculosis
Mycobacterium tuberculosis
Animals
Spain
Seroepidemiologic Studies
Risk Factors
Female
Enzyme-Linked Immunosorbent Assay
Male
Prevalence
topic Goats
Goat Diseases
Tuberculosis
Mycobacterium tuberculosis
Animals
Spain
Seroepidemiologic Studies
Risk Factors
Female
Enzyme-Linked Immunosorbent Assay
Male
Prevalence
description Tuberculosis (TB) is a zoonotic infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTC), which can affect a wide variety of domestic and wild animal species. Although the role of goats as a reservoir of MTC bacteria has been evidenced, information about the circulation of MTC strains in this species is still very scarce. The aim of the present study was to determine the seroprevalence, spatial distribution, risk factors and MTC spoligotypes circulating in goats from Andalusia (Southern Spain), the Spanish region with the largest goat census and a hotspot area of TB in both cattle and wild ungulates. A total of 2155 serum samples from 80 goat flocks were analyzed by an in-house ELISA using the P22 protein complex as a coating antigen. Antibodies against MTC were detected in 473 goats (21.9%, 95% CI: 20.2-23.7) and the true seroprevalence was 22.3% (95% CI: 20.6-24.1). Seropositivity was found in 72 (90.0%) of the 80 flocks analyzed. The generalized estimating equation model showed that the management system (higher seroprevalence on intensive and semi-intensive farms), and the presence of hospital pens inside the regular stables, were risk factors potentially associated with MTC exposure in goats in Southern Spain. The spatial analysis identified a significant spatial cluster (p < 0.001) in Eastern Andalusia. A total of 16 different MTC spoligotypes, including five of M. caprae and eleven of M. bovis, were identified in goats between 2015 and 2022 in the study area, with SB0157 as the most frequently isolated. The results obtained indicate widespread and non-homogeneous spatial distribution of MTC in goat herds from Southern Spain. The high individual and herd-level seroprevalence values found suggest that goats could play a significant role in the maintenance and transmission of MTC in the study area. Our results highlight the importance of implementing control measures in this species.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-03
2024
2024-06-01
2024
2024-06-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/19924
url http://hdl.handle.net/20.500.12105/19924
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv EC UCO-FEDER-1381385-R Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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