Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]

Figure 1. S. cerevisiae strains adapted to human feces are tolerant to high iron concentrations. Figure 2. Sensibility of S. cerevisiae yeast strains to iron scarcity. Figure 3. Glycine 195 is a conserved residue in tandem-zinc finger proteins similar to Cth2. Figure 4. The CTH2-G195R allele leads t...

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Detalles Bibliográficos
Autores: Valera García, Elena, Sorribes Dauden, Raquel, Martínez-Pastor, María Teresa, Puig, Sergi
Tipo de recurso: conjunto de datos
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/389745
Acceso en línea:http://hdl.handle.net/10261/389745
https://doi.org/10.20350/digitalCSIC/17292
Access Level:acceso abierto
Palabra clave:Saccharomyces cerevisiae
Yeast diversity
Iron deficiency
mRNA-binding
Nucleo-cytoplasmic shuttling
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spelling Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]Valera García, ElenaSorribes Dauden, RaquelMartínez-Pastor, María TeresaPuig, SergiSaccharomyces cerevisiaeYeast diversityIron deficiencymRNA-bindingNucleo-cytoplasmic shuttlingSaccharomyces cerevisiaeIron deficiencyFigure 1. S. cerevisiae strains adapted to human feces are tolerant to high iron concentrations. Figure 2. Sensibility of S. cerevisiae yeast strains to iron scarcity. Figure 3. Glycine 195 is a conserved residue in tandem-zinc finger proteins similar to Cth2. Figure 4. The CTH2-G195R allele leads to a growth defect in iron-deficient conditions. Figure 5. The CTH2-G195R allele limits the downregulation of ARE-containing mRNAs. Figure 6. Glycine 195 is essential for the in vivo interaction between Cth2 protein with its target mRNAs. Figure 7. Cth2-G195R protein accumulates in the nucleus. Figure 8. Wild yeast strains expressing CTH2-G195R are defective in Cth2-mediated mRNA downregulation. Figure 9. The replacement of CTH2-R195 by CTH2-G195 allele improves the growth of a set of wild yeast strains in iron-deficient conditions. Figure S1. S. cerevisiae strains adapted to human feces are tolerant to high iron concentrations. Figure S2. Sensibility of S. cerevisiae yeast strains to iron scarcity. Figure S3. The CTH2-G195R allele leads to a growth defect in iron-deficient conditions. Figure S4. The CTH2-G195R allele limits the downregulation of ARE-containing mRNAs. Figure S5. Wild yeast strains expressing CTH2-G195R are defective in Cth2-mediated mRNA downregulation. Figure S6. Sensibility of S. cerevisiae yeast strains to iron scarcity.This research was supported by the MCIN/AEI/10.13039/501100011033 under grants PID2020-116940RB-I00, PID2023-148124OB-I00 and CEX2021-001189-S, and by the Spanish Ministry of Science and Innovation under the predoctoral fellowship PRE2021-096933.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2021-001189-S)Peer reviewedDIGITAL.CSICMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)Puig, Sergi [0000-0002-1856-490X]Martínez Pastor,María Teresa [0000-0002-4128-958X]Puig, Sergi [spuig@iata.csic.es]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1application/ziphttp://hdl.handle.net/10261/389745https://doi.org/10.20350/digitalCSIC/17292reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001189-Sinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116940RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-148124OB-I00Valera-García, E.; Sorribes-Dauden, R.; Puig, S. 2025; A Mutation in the RNA-Binding Protein Cth2 Limits the Adaptation of a Subset of Wild Saccharomyces cerevisiae Yeast Strains to Iron Deficiency. http://doi.org/10.1080/10985549.2025.2539754; http://hdl.handle.net/10261/401330Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3897452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
title Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
spellingShingle Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
Valera García, Elena
Saccharomyces cerevisiae
Yeast diversity
Iron deficiency
mRNA-binding
Nucleo-cytoplasmic shuttling
Saccharomyces cerevisiae
Iron deficiency
title_short Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
title_full Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
title_fullStr Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
title_full_unstemmed Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
title_sort Raw data and analysis of the data corresponding to the manuscript A mutation in the RNA-binding protein Cth2 limits the adaptation of a subset of wild Saccharomyces cerevisiae yeast strains to iron deficiency [DATASET]
dc.creator.none.fl_str_mv Valera García, Elena
Sorribes Dauden, Raquel
Martínez-Pastor, María Teresa
Puig, Sergi
author Valera García, Elena
author_facet Valera García, Elena
Sorribes Dauden, Raquel
Martínez-Pastor, María Teresa
Puig, Sergi
author_role author
author2 Sorribes Dauden, Raquel
Martínez-Pastor, María Teresa
Puig, Sergi
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
Puig, Sergi [0000-0002-1856-490X]
Martínez Pastor,María Teresa [0000-0002-4128-958X]
Puig, Sergi [spuig@iata.csic.es]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Saccharomyces cerevisiae
Yeast diversity
Iron deficiency
mRNA-binding
Nucleo-cytoplasmic shuttling
Saccharomyces cerevisiae
Iron deficiency
topic Saccharomyces cerevisiae
Yeast diversity
Iron deficiency
mRNA-binding
Nucleo-cytoplasmic shuttling
Saccharomyces cerevisiae
Iron deficiency
description Figure 1. S. cerevisiae strains adapted to human feces are tolerant to high iron concentrations. Figure 2. Sensibility of S. cerevisiae yeast strains to iron scarcity. Figure 3. Glycine 195 is a conserved residue in tandem-zinc finger proteins similar to Cth2. Figure 4. The CTH2-G195R allele leads to a growth defect in iron-deficient conditions. Figure 5. The CTH2-G195R allele limits the downregulation of ARE-containing mRNAs. Figure 6. Glycine 195 is essential for the in vivo interaction between Cth2 protein with its target mRNAs. Figure 7. Cth2-G195R protein accumulates in the nucleus. Figure 8. Wild yeast strains expressing CTH2-G195R are defective in Cth2-mediated mRNA downregulation. Figure 9. The replacement of CTH2-R195 by CTH2-G195 allele improves the growth of a set of wild yeast strains in iron-deficient conditions. Figure S1. S. cerevisiae strains adapted to human feces are tolerant to high iron concentrations. Figure S2. Sensibility of S. cerevisiae yeast strains to iron scarcity. Figure S3. The CTH2-G195R allele leads to a growth defect in iron-deficient conditions. Figure S4. The CTH2-G195R allele limits the downregulation of ARE-containing mRNAs. Figure S5. Wild yeast strains expressing CTH2-G195R are defective in Cth2-mediated mRNA downregulation. Figure S6. Sensibility of S. cerevisiae yeast strains to iron scarcity.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/389745
https://doi.org/10.20350/digitalCSIC/17292
url http://hdl.handle.net/10261/389745
https://doi.org/10.20350/digitalCSIC/17292
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116940RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-148124OB-I00
Valera-García, E.; Sorribes-Dauden, R.; Puig, S. 2025; A Mutation in the RNA-Binding Protein Cth2 Limits the Adaptation of a Subset of Wild Saccharomyces cerevisiae Yeast Strains to Iron Deficiency. http://doi.org/10.1080/10985549.2025.2539754; http://hdl.handle.net/10261/401330
Sí
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dc.publisher.none.fl_str_mv DIGITAL.CSIC
publisher.none.fl_str_mv DIGITAL.CSIC
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