Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression

Non-alcoholic fatty liver disease; Polycystic ovary syndrome; Risk factors

Detalles Bibliográficos
Autores: Manzano Nuñez, Ramiro, Santana-Dominguez, Marta, Rivera Esteban, Jesus Manuel, Sabiote Cartes, Clara, de Sena Fernández, Elena, Bañares Sanchez, Juan, Tacke, Frank, Pericàs Pulido, Juan Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/9172
Acceso en línea:https://hdl.handle.net/11351/9172
Access Level:acceso abierto
Palabra clave:Esteatosi hepàtica - Factors de risc
Síndrome dels ovaris poliquístics - Complicacions
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::/diagnosis
DISEASES::Endocrine System Diseases::Gonadal Disorders::Ovarian Diseases::Ovarian Cysts::Polycystic Ovary Syndrome
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica
Otros calificadores::Otros calificadores::/diagnóstico
ENFERMEDADES::enfermedades del sistema endocrino::trastornos gonadales::enfermedades del ovario::quistes ováricos::síndrome del ovario poliquístico
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/9172
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
title Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
spellingShingle Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
Manzano Nuñez, Ramiro
Esteatosi hepàtica - Factors de risc
Síndrome dels ovaris poliquístics - Complicacions
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::/diagnosis
DISEASES::Endocrine System Diseases::Gonadal Disorders::Ovarian Diseases::Ovarian Cysts::Polycystic Ovary Syndrome
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica
Otros calificadores::Otros calificadores::/diagnóstico
ENFERMEDADES::enfermedades del sistema endocrino::trastornos gonadales::enfermedades del ovario::quistes ováricos::síndrome del ovario poliquístico
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
title_short Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
title_full Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
title_fullStr Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
title_full_unstemmed Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
title_sort Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
dc.creator.none.fl_str_mv Manzano Nuñez, Ramiro
Santana-Dominguez, Marta
Rivera Esteban, Jesus Manuel
Sabiote Cartes, Clara
de Sena Fernández, Elena
Bañares Sanchez, Juan
Tacke, Frank
Pericàs Pulido, Juan Manuel
author Manzano Nuñez, Ramiro
author_facet Manzano Nuñez, Ramiro
Santana-Dominguez, Marta
Rivera Esteban, Jesus Manuel
Sabiote Cartes, Clara
de Sena Fernández, Elena
Bañares Sanchez, Juan
Tacke, Frank
Pericàs Pulido, Juan Manuel
author_role author
author2 Santana-Dominguez, Marta
Rivera Esteban, Jesus Manuel
Sabiote Cartes, Clara
de Sena Fernández, Elena
Bañares Sanchez, Juan
Tacke, Frank
Pericàs Pulido, Juan Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Manzano-Nunez R, Rivera-Esteban J] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Santana-Dominguez M] Gynecology and Obstetrics Department, Hospital Clínic de Barcelona, Barcelona, Spain. [Sabiote C, Sena E, Bañares J] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Tacke F] Department of Hepatology & Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany. [Pericàs JM] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centros de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Esteatosi hepàtica - Factors de risc
Síndrome dels ovaris poliquístics - Complicacions
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::/diagnosis
DISEASES::Endocrine System Diseases::Gonadal Disorders::Ovarian Diseases::Ovarian Cysts::Polycystic Ovary Syndrome
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica
Otros calificadores::Otros calificadores::/diagnóstico
ENFERMEDADES::enfermedades del sistema endocrino::trastornos gonadales::enfermedades del ovario::quistes ováricos::síndrome del ovario poliquístico
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
topic Esteatosi hepàtica - Factors de risc
Síndrome dels ovaris poliquístics - Complicacions
DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
Other subheadings::Other subheadings::/diagnosis
DISEASES::Endocrine System Diseases::Gonadal Disorders::Ovarian Diseases::Ovarian Cysts::Polycystic Ovary Syndrome
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica
Otros calificadores::Otros calificadores::/diagnóstico
ENFERMEDADES::enfermedades del sistema endocrino::trastornos gonadales::enfermedades del ovario::quistes ováricos::síndrome del ovario poliquístico
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
description Non-alcoholic fatty liver disease; Polycystic ovary syndrome; Risk factors
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9172
url https://hdl.handle.net/11351/9172
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine;12(3)
https://doi.org/10.3390/jcm12030856
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404975622258688
spelling Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-RegressionManzano Nuñez, RamiroSantana-Dominguez, MartaRivera Esteban, Jesus ManuelSabiote Cartes, Clarade Sena Fernández, ElenaBañares Sanchez, JuanTacke, FrankPericàs Pulido, Juan ManuelEsteatosi hepàtica - Factors de riscSíndrome dels ovaris poliquístics - ComplicacionsDISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver DiseaseOther subheadings::Other subheadings::/diagnosisDISEASES::Endocrine System Diseases::Gonadal Disorders::Ovarian Diseases::Ovarian Cysts::Polycystic Ovary SyndromeOther subheadings::Other subheadings::Other subheadings::/complicationsENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólicaOtros calificadores::Otros calificadores::/diagnósticoENFERMEDADES::enfermedades del sistema endocrino::trastornos gonadales::enfermedades del ovario::quistes ováricos::síndrome del ovario poliquísticoOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesNon-alcoholic fatty liver disease; Polycystic ovary syndrome; Risk factorsMalaltia del fetge gras no alcohòlic; Síndrome d'ovari poliquístic; Factors de riscEnfermedad del hígado graso no alcohólico; Síndrome de ovario poliquistico; Factores de riesgoBackground: The metabolic effects of polycystic ovary syndrome (PCOS) may increase the risk of non-alcoholic fatty liver disease (NAFLD). However, the burden of NAFLD in PCOS has not been unequivocally defined. This systematic review (SR), meta-analysis (MA) assessed NAFLD’s prevalence, and risk factors in patients with PCOS. Methods: A literature search was performed in MEDLINE, Scopus, and Scielo. First, we performed a MA of proportions to estimate the prevalence of NAFLD in PCOS. Second, we performed meta-analyses of precalculated adjusted odds ratios to examine NAFLD risk factors. Finally, we performed a meta-regression to model how the estimated prevalence changed with changes in prespecified variables. Results: We identified 817 articles from the database searches. Thirty-six were included. MA of proportions found a pooled NAFLD prevalence of 43% (95% CI, 35–52%) with high heterogeneity (I2 = 97.2%). BMI, waist circumference, ALT values, HOMA-IR values, free androgen index levels, hyperandrogenism, and triglycerides were associated with significantly higher risk-adjusted odds of NAFLD among patients with PCOS. Meta-regression showed that rises in NAFLD prevalence were mediated through increases in metabolic syndrome prevalence and higher levels of HOMA-IR, free androgen index, and total testosterone. Conclusion: The prevalence of NAFLD (43%) among PCOS patients is high despite their average young age, with several metabolic and PCOS-specific factors influencing its occurrence. Screening programs may aid in detecting metabolic-associated fatty liver disease and prevent its consequences. Further work is required to establish the burden of liver-related outcomes once NAFLD has progressed in the PCOS population.MDPIInstitut Català de la Salut[Manzano-Nunez R, Rivera-Esteban J] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Santana-Dominguez M] Gynecology and Obstetrics Department, Hospital Clínic de Barcelona, Barcelona, Spain. [Sabiote C, Sena E, Bañares J] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Tacke F] Department of Hepatology & Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany. [Pericàs JM] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centros de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9172Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésJournal of Clinical Medicine;12(3)https://doi.org/10.3390/jcm12030856Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/91722026-06-12T09:38:37Z
score 15,812429

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