Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods: In the Pregnancy And Childhood Epigenetics (PACE...

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Autores: Sharp, Gemma C., Alfano, Rossella, Ghantous, Akram, Urquiza, José M., Rifas-Shiman, Sheryl L., Page, Christian M., Jin, Jianping, Fernández-Barrés, Sílvia, Santorelli, Gillian, Tindula, Gwen, Pregnancy and Childhood Epigenetics (PACE) consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/53214
Acceso en línea:http://hdl.handle.net/10230/53214
http://dx.doi.org/10.1093/ije/dyaa267
Access Level:acceso abierto
Palabra clave:DNA methylation
DOHaD
Paternal
Body mass index
Epigenetics
Fathers
Pregnancy
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spelling Paternal body mass index and offspring DNA methylation: findings from the PACE consortiumSharp, Gemma C.Alfano, RossellaGhantous, AkramUrquiza, José M.Rifas-Shiman, Sheryl L.Page, Christian M.Jin, JianpingFernández-Barrés, SílviaSantorelli, GillianTindula, GwenPregnancy and Childhood Epigenetics (PACE) consortiumDNA methylationDOHaDPaternalBody mass indexEpigeneticsFathersPregnancyBackground: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods: In the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of coordinated epigenome-wide association studies (EWAS) of paternal prenatal body mass index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 data sets; total n = 4894) and in childhood (6 data sets; total n = 1982). Results: We found little evidence of an association at either time point: at all CpGs, the false-discovery-rate-adjusted P-values were >0.05. In secondary sex-stratified analyses, we found just four CpGs for which there was robust evidence of an association in female offspring. To compare our findings to those of other studies, we conducted a systematic review, which identified seven studies, including five candidate gene studies showing associations between paternal BMI/obesity and offspring or sperm DNA methylation at imprinted regions. However, in our own study, we found very little evidence of enrichment for imprinted genes. Conclusion: Our findings do not support the hypothesis that paternal BMI around the time of pregnancy is associated with offspring-blood DNA methylation, even at imprinted regions.Oxford University Press202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53214http://dx.doi.org/10.1093/ije/dyaa267reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInt J Epidemiol. 2021 Aug 30;50(4):1297-315© The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/532142026-06-12T07:21:37Z
dc.title.none.fl_str_mv Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
title Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
spellingShingle Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
Sharp, Gemma C.
DNA methylation
DOHaD
Paternal
Body mass index
Epigenetics
Fathers
Pregnancy
title_short Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
title_full Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
title_fullStr Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
title_full_unstemmed Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
title_sort Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
dc.creator.none.fl_str_mv Sharp, Gemma C.
Alfano, Rossella
Ghantous, Akram
Urquiza, José M.
Rifas-Shiman, Sheryl L.
Page, Christian M.
Jin, Jianping
Fernández-Barrés, Sílvia
Santorelli, Gillian
Tindula, Gwen
Pregnancy and Childhood Epigenetics (PACE) consortium
author Sharp, Gemma C.
author_facet Sharp, Gemma C.
Alfano, Rossella
Ghantous, Akram
Urquiza, José M.
Rifas-Shiman, Sheryl L.
Page, Christian M.
Jin, Jianping
Fernández-Barrés, Sílvia
Santorelli, Gillian
Tindula, Gwen
Pregnancy and Childhood Epigenetics (PACE) consortium
author_role author
author2 Alfano, Rossella
Ghantous, Akram
Urquiza, José M.
Rifas-Shiman, Sheryl L.
Page, Christian M.
Jin, Jianping
Fernández-Barrés, Sílvia
Santorelli, Gillian
Tindula, Gwen
Pregnancy and Childhood Epigenetics (PACE) consortium
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DNA methylation
DOHaD
Paternal
Body mass index
Epigenetics
Fathers
Pregnancy
topic DNA methylation
DOHaD
Paternal
Body mass index
Epigenetics
Fathers
Pregnancy
description Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods: In the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of coordinated epigenome-wide association studies (EWAS) of paternal prenatal body mass index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 data sets; total n = 4894) and in childhood (6 data sets; total n = 1982). Results: We found little evidence of an association at either time point: at all CpGs, the false-discovery-rate-adjusted P-values were >0.05. In secondary sex-stratified analyses, we found just four CpGs for which there was robust evidence of an association in female offspring. To compare our findings to those of other studies, we conducted a systematic review, which identified seven studies, including five candidate gene studies showing associations between paternal BMI/obesity and offspring or sperm DNA methylation at imprinted regions. However, in our own study, we found very little evidence of enrichment for imprinted genes. Conclusion: Our findings do not support the hypothesis that paternal BMI around the time of pregnancy is associated with offspring-blood DNA methylation, even at imprinted regions.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53214
http://dx.doi.org/10.1093/ije/dyaa267
url http://hdl.handle.net/10230/53214
http://dx.doi.org/10.1093/ije/dyaa267
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Epidemiol. 2021 Aug 30;50(4):1297-315
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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