Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.

The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females acti...

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Autores: Gómez-García I, Trepiana J, Fernández-Quintela A, Giralt M, Portillo MP
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p21905
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21905
https://www.mdpi.com/1422-0067/23/15/8250
Access Level:acceso abierto
Palabra clave:brown adipose tissue
browning
sex hormones
sexual dimorphism
thermogenesis
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spelling Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.Gómez-García ITrepiana JFernández-Quintela AGiralt MPortillo MPbrown adipose tissuebrowningsex hormonessexual dimorphismthermogenesisThe present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans go in the same line, although they do not provide results as solid as those obtained in rodents. Regarding the effects of overfeeding, interesting sex differences on BAT thermogenic capacity have been reported, and the greater or lower sensitivity of each sex to this dietary situation seems to be dependent on the type of feeding. In the case of energy restriction, females are more sensitive than males. In addition, sex differences have also been observed in thermogenesis changes induced by phenolic compound administration. During sexual development, an increase in BAT mass and BAT activity takes place. This phenomenon is greater in boys than in girls, probably due to its relation to muscle-mass growth. The opposite situation takes place during ageing, a lifespan period where thermogenic capacity declines, this being more acute in men than in women. Finally, the vast majority of the studies have reported a higher susceptibility to developing WAT browning amongst females. The scarcity of results highlights the need for further studies devoted to analysing this issue, in order to provide valuable information for a more personalised approach.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21905https://www.mdpi.com/1422-0067/23/15/8250INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESISSN: 16616596ISSNe: 14220067reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p219052026-05-27T12:37:41Z
dc.title.none.fl_str_mv Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
title Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
spellingShingle Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
Gómez-García I
brown adipose tissue
browning
sex hormones
sexual dimorphism
thermogenesis
title_short Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
title_full Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
title_fullStr Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
title_full_unstemmed Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
title_sort Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning.
dc.creator.none.fl_str_mv Gómez-García I
Trepiana J
Fernández-Quintela A
Giralt M
Portillo MP
author Gómez-García I
author_facet Gómez-García I
Trepiana J
Fernández-Quintela A
Giralt M
Portillo MP
author_role author
author2 Trepiana J
Fernández-Quintela A
Giralt M
Portillo MP
author2_role author
author
author
author
dc.subject.none.fl_str_mv brown adipose tissue
browning
sex hormones
sexual dimorphism
thermogenesis
topic brown adipose tissue
browning
sex hormones
sexual dimorphism
thermogenesis
description The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans go in the same line, although they do not provide results as solid as those obtained in rodents. Regarding the effects of overfeeding, interesting sex differences on BAT thermogenic capacity have been reported, and the greater or lower sensitivity of each sex to this dietary situation seems to be dependent on the type of feeding. In the case of energy restriction, females are more sensitive than males. In addition, sex differences have also been observed in thermogenesis changes induced by phenolic compound administration. During sexual development, an increase in BAT mass and BAT activity takes place. This phenomenon is greater in boys than in girls, probably due to its relation to muscle-mass growth. The opposite situation takes place during ageing, a lifespan period where thermogenic capacity declines, this being more acute in men than in women. Finally, the vast majority of the studies have reported a higher susceptibility to developing WAT browning amongst females. The scarcity of results highlights the need for further studies devoted to analysing this issue, in order to provide valuable information for a more personalised approach.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21905
https://www.mdpi.com/1422-0067/23/15/8250
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21905
https://www.mdpi.com/1422-0067/23/15/8250
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 16616596
ISSNe: 14220067
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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