What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study
[Background] Microbial communities in human milk and those in feces from breastfed infants vary within and across populations. However, few researchers have conducted cross-cultural comparisons between populations, and little is known about whether certain “core” taxa occur normally within or betwee...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/208559 |
| Acceso en línea: | http://hdl.handle.net/10261/208559 |
| Access Level: | acceso abierto |
| Palabra clave: | Human milk Breastmilk Feces Microbiome International Infant Breastfeeding Maternal |
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| dc.title.none.fl_str_mv |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| title |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| spellingShingle |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study Lackey, Kimberly A. Human milk Breastmilk Feces Microbiome International Infant Breastfeeding Maternal |
| title_short |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| title_full |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| title_fullStr |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| title_full_unstemmed |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| title_sort |
What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire study |
| dc.creator.none.fl_str_mv |
Lackey, Kimberly A. Williams, Janet E. Meehan, Courtney L. Zachek, Jessica A. Benda, Elisabeth D. Price, William J. Foster, James A. Sellen, Daniel W. Kamau‐Mbuthia, Elizabeth W. Kamundia, Egidioh W. Mbugua, Samwel Moore, Sophie E. Prentice, Andrew M. Gindola, Debela Kvist, Linda J. Otto, Gloria E. García-Carral, Cristina Jiménez, Esther Ruíz García, Lorena Rodríguez, Juan M. Pareja, Rossina G. Bode, Lars McGuire, Mark A. McGuire, Michelle K. |
| author |
Lackey, Kimberly A. |
| author_facet |
Lackey, Kimberly A. Williams, Janet E. Meehan, Courtney L. Zachek, Jessica A. Benda, Elisabeth D. Price, William J. Foster, James A. Sellen, Daniel W. Kamau‐Mbuthia, Elizabeth W. Kamundia, Egidioh W. Mbugua, Samwel Moore, Sophie E. Prentice, Andrew M. Gindola, Debela Kvist, Linda J. Otto, Gloria E. García-Carral, Cristina Jiménez, Esther Ruíz García, Lorena Rodríguez, Juan M. Pareja, Rossina G. Bode, Lars McGuire, Mark A. McGuire, Michelle K. |
| author_role |
author |
| author2 |
Williams, Janet E. Meehan, Courtney L. Zachek, Jessica A. Benda, Elisabeth D. Price, William J. Foster, James A. Sellen, Daniel W. Kamau‐Mbuthia, Elizabeth W. Kamundia, Egidioh W. Mbugua, Samwel Moore, Sophie E. Prentice, Andrew M. Gindola, Debela Kvist, Linda J. Otto, Gloria E. García-Carral, Cristina Jiménez, Esther Ruíz García, Lorena Rodríguez, Juan M. Pareja, Rossina G. Bode, Lars McGuire, Mark A. McGuire, Michelle K. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
National Science Foundation (US) Ministerio de Economía y Competitividad (España) European Commission Ruíz García, Lorena [0000-0001-8199-5502] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Human milk Breastmilk Feces Microbiome International Infant Breastfeeding Maternal |
| topic |
Human milk Breastmilk Feces Microbiome International Infant Breastfeeding Maternal |
| description |
[Background] Microbial communities in human milk and those in feces from breastfed infants vary within and across populations. However, few researchers have conducted cross-cultural comparisons between populations, and little is known about whether certain “core” taxa occur normally within or between populations and whether variation in milk microbiome is related to variation in infant fecal microbiome. The purpose of this study was to describe microbiomes of milk produced by relatively healthy women living at diverse international sites and compare these to the fecal microbiomes of their relatively healthy infants. [Methods] We analyzed milk (n = 394) and infant feces (n = 377) collected from mother/infant dyads living in 11 international sites (2 each in Ethiopia, The Gambia, and the US; 1 each in Ghana, Kenya, Peru, Spain, and Sweden). The V1-V3 region of the bacterial 16S rRNA gene was sequenced to characterize and compare microbial communities within and among cohorts. [Results] Core genera in feces were Streptococcus, Escherichia/Shigella, and Veillonella, and in milk were Streptococcus and Staphylococcus, although substantial variability existed within and across cohorts. For instance, relative abundance of Lactobacillus was highest in feces from rural Ethiopia and The Gambia, and lowest in feces from Peru, Spain, Sweden, and the US; Rhizobium was relatively more abundant in milk produced by women in rural Ethiopia than all other cohorts. Bacterial diversity also varied among cohorts. For example, Shannon diversity was higher in feces from Kenya than Ghana and US-California, and higher in rural Ethiopian than Ghana, Peru, Spain, Sweden, and US-California. There were limited associations between individual genera in milk and feces, but community-level analyses suggest strong, positive associations between the complex communities in these sample types. [Conclusions] Our data provide additional evidence of within- and among-population differences in milk and infant fecal bacterial community membership and diversity and support for a relationship between the bacterial communities in milk and those of the recipient infant's feces. Additional research is needed to understand environmental, behavioral, and genetic factors driving this variation and association, as well as its significance for acute and chronic maternal and infant health. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2020 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/208559 |
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http://hdl.handle.net/10261/208559 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869404968292712448 |
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What's normal? Microbiomes in human milk and infant feces are related to each other but vary geographically: The inspire studyLackey, Kimberly A.Williams, Janet E.Meehan, Courtney L.Zachek, Jessica A.Benda, Elisabeth D.Price, William J.Foster, James A.Sellen, Daniel W.Kamau‐Mbuthia, Elizabeth W.Kamundia, Egidioh W.Mbugua, SamwelMoore, Sophie E.Prentice, Andrew M.Gindola, DebelaKvist, Linda J.Otto, Gloria E.García-Carral, CristinaJiménez, EstherRuíz García, LorenaRodríguez, Juan M.Pareja, Rossina G.Bode, LarsMcGuire, Mark A.McGuire, Michelle K.Human milkBreastmilkFecesMicrobiomeInternationalInfantBreastfeedingMaternal[Background] Microbial communities in human milk and those in feces from breastfed infants vary within and across populations. However, few researchers have conducted cross-cultural comparisons between populations, and little is known about whether certain “core” taxa occur normally within or between populations and whether variation in milk microbiome is related to variation in infant fecal microbiome. The purpose of this study was to describe microbiomes of milk produced by relatively healthy women living at diverse international sites and compare these to the fecal microbiomes of their relatively healthy infants. [Methods] We analyzed milk (n = 394) and infant feces (n = 377) collected from mother/infant dyads living in 11 international sites (2 each in Ethiopia, The Gambia, and the US; 1 each in Ghana, Kenya, Peru, Spain, and Sweden). The V1-V3 region of the bacterial 16S rRNA gene was sequenced to characterize and compare microbial communities within and among cohorts. [Results] Core genera in feces were Streptococcus, Escherichia/Shigella, and Veillonella, and in milk were Streptococcus and Staphylococcus, although substantial variability existed within and across cohorts. For instance, relative abundance of Lactobacillus was highest in feces from rural Ethiopia and The Gambia, and lowest in feces from Peru, Spain, Sweden, and the US; Rhizobium was relatively more abundant in milk produced by women in rural Ethiopia than all other cohorts. Bacterial diversity also varied among cohorts. For example, Shannon diversity was higher in feces from Kenya than Ghana and US-California, and higher in rural Ethiopian than Ghana, Peru, Spain, Sweden, and US-California. There were limited associations between individual genera in milk and feces, but community-level analyses suggest strong, positive associations between the complex communities in these sample types. [Conclusions] Our data provide additional evidence of within- and among-population differences in milk and infant fecal bacterial community membership and diversity and support for a relationship between the bacterial communities in milk and those of the recipient infant's feces. Additional research is needed to understand environmental, behavioral, and genetic factors driving this variation and association, as well as its significance for acute and chronic maternal and infant health.This study was supported by the National Science Foundation (award 1344288), the Ministry of Economy and Competitiveness, Spain (project AGL2013-4190-P), and the European Commission [grant 624773 (FP-7-PEOPLE-2013-IEF)]. Sterile, single-use milk-collection kits were generously provided by Medela Inc. This work was supported in part by NIH COBRE Phase III grant P30GM103324.Frontiers MediaNational Science Foundation (US)Ministerio de Economía y Competitividad (España)European CommissionRuíz García, Lorena [0000-0001-8199-5502]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/208559reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-4190-Pinfo:eu-repo/grantAgreement/EC/FP7/624773http://dx.doi.org/10.3389/fnut.2019.00045Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2085592026-05-22T06:33:51Z |
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15,812429 |