How Dispersion Interactions at the Excited State Can Tune Photochromism of Embedded Chromophores

We present QM/MMPol-cLR<sup>3</sup>, a polarizable embedding quantum mechanics/molecular mechanics (QM/MM) framework that includes explicit, state-specific dispersion terms. This method enables a rigorous treatment of dispersion on top of electrostatic and induction effects in ground- an...

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Detalhes bibliográficos
Autores: Guido, Ciro A., Cupellini, Lorenzo, Mennucci, Benedetta, Curutchet Barat, Carles E.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2026
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/225923
Acesso em linha:https://hdl.handle.net/2445/225923
Access Level:acceso embargado
Palavra-chave:Col·loides
Polaritat
Dissolvents
Colloids
Polarity
Solvents
Descrição
Resumo:We present QM/MMPol-cLR<sup>3</sup>, a polarizable embedding quantum mechanics/molecular mechanics (QM/MM) framework that includes explicit, state-specific dispersion terms. This method enables a rigorous treatment of dispersion on top of electrostatic and induction effects in ground- and excited-state calculations. Using QM/MMPol-cLR<sup>3</sup>, we show that dispersion interactions control excited-state solvatochromism through two distinct mechanisms. In azulene, opposite shifts of the L<sub>a</sub> and L<sub>b</sub> states arise from state-specific dispersion linked to changes in excited-state polarizability. In bacteriochlorophyll a, dispersion instead stems from the interplay between polarizability changes and transition-dipole-driven response, governing the <em>Q</em><sub><em>y</em></sub> and <em>Q</em><sub><em>x</em></sub> shifts. Finally, application to the LH2 complex reveals pigment-dependent dispersion shifts between the B800 and B850 rings, impacting the excitation-energy transfer. These results establish dispersion as an essential, nonempirical component for predictive excited-state simulations in complex environments.