Novel Antithrombotic Agents in Ischemic Cardiovascular Disease

Ischemic cardiovascular diseases have a high incidence and high mortality worldwide. Therapeutic advances in the last decades have reduced cardiovascular mortality, with antithrombotic therapy being the cornerstone of medical treatment. Yet, currently used antithrombotic agents carry an inherent ris...

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Autores: Barriuso, I., Worner Diz, Fernando|||0000-0001-7993-7709, Vilahur, Gemma|||0000-0002-2828-8873
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:275208
Acceso en línea:https://ddd.uab.cat/record/275208
https://dx.doi.org/urn:doi:10.3390/jcdd9110397
Access Level:acceso abierto
Palabra clave:Cardiovascular diseases
Novel antithrombotic agents
Antiplatelet drugs
Anticoagulants
Hemostasis
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spelling Novel Antithrombotic Agents in Ischemic Cardiovascular DiseaseProgress in the Search for the Optimal TreatmentBarriuso, I.Worner Diz, Fernando|||0000-0001-7993-7709Vilahur, Gemma|||0000-0002-2828-8873Cardiovascular diseasesNovel antithrombotic agentsAntiplatelet drugsAnticoagulantsHemostasisIschemic cardiovascular diseases have a high incidence and high mortality worldwide. Therapeutic advances in the last decades have reduced cardiovascular mortality, with antithrombotic therapy being the cornerstone of medical treatment. Yet, currently used antithrombotic agents carry an inherent risk of bleeding associated with adverse cardiovascular outcomes and mortality. Advances in understanding the pathophysiology of thrombus formation have led to the discovery of new targets and the development of new anticoagulants and antiplatelet agents aimed at preventing thrombus stabilization and growth while preserving hemostasis. In the following review, we will comment on the key limitation of the currently used antithrombotic regimes in ischemic heart disease and ischemic stroke and provide an in-depth and state-of-the-art overview of the emerging anticoagulant and antiplatelet agents in the pipeline with the potential to improve clinical outcomes.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/275208https://dx.doi.org/urn:doi:10.3390/jcdd9110397reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PLEC2021-007664Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-128891OB-I00open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2752082026-06-06T12:50:31Z
dc.title.none.fl_str_mv Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
Progress in the Search for the Optimal Treatment
title Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
spellingShingle Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
Barriuso, I.
Cardiovascular diseases
Novel antithrombotic agents
Antiplatelet drugs
Anticoagulants
Hemostasis
title_short Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
title_full Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
title_fullStr Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
title_full_unstemmed Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
title_sort Novel Antithrombotic Agents in Ischemic Cardiovascular Disease
dc.creator.none.fl_str_mv Barriuso, I.
Worner Diz, Fernando|||0000-0001-7993-7709
Vilahur, Gemma|||0000-0002-2828-8873
author Barriuso, I.
author_facet Barriuso, I.
Worner Diz, Fernando|||0000-0001-7993-7709
Vilahur, Gemma|||0000-0002-2828-8873
author_role author
author2 Worner Diz, Fernando|||0000-0001-7993-7709
Vilahur, Gemma|||0000-0002-2828-8873
author2_role author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Cardiovascular diseases
Novel antithrombotic agents
Antiplatelet drugs
Anticoagulants
Hemostasis
topic Cardiovascular diseases
Novel antithrombotic agents
Antiplatelet drugs
Anticoagulants
Hemostasis
description Ischemic cardiovascular diseases have a high incidence and high mortality worldwide. Therapeutic advances in the last decades have reduced cardiovascular mortality, with antithrombotic therapy being the cornerstone of medical treatment. Yet, currently used antithrombotic agents carry an inherent risk of bleeding associated with adverse cardiovascular outcomes and mortality. Advances in understanding the pathophysiology of thrombus formation have led to the discovery of new targets and the development of new anticoagulants and antiplatelet agents aimed at preventing thrombus stabilization and growth while preserving hemostasis. In the following review, we will comment on the key limitation of the currently used antithrombotic regimes in ischemic heart disease and ischemic stroke and provide an in-depth and state-of-the-art overview of the emerging anticoagulant and antiplatelet agents in the pipeline with the potential to improve clinical outcomes.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/275208
https://dx.doi.org/urn:doi:10.3390/jcdd9110397
url https://ddd.uab.cat/record/275208
https://dx.doi.org/urn:doi:10.3390/jcdd9110397
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PLEC2021-007664
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2021-128891OB-I00
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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