MicroRNA precursors are not structurally robust but plastic

Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as p...

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Detalles Bibliográficos
Autores: Rodrigo, Guillermo, Elena, Santiago F.
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/92950
Acceso en línea:http://hdl.handle.net/10261/92950
Access Level:acceso abierto
Palabra clave:Conformational flexibility
Evolvability
Non-coding RNA
secondary structure
thermodynamics
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spelling MicroRNA precursors are not structurally robust but plasticRodrigo, GuillermoElena, Santiago F.Conformational flexibilityEvolvabilityNon-coding RNAsecondary structurethermodynamicsRobustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate nullmodel. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs. © 2012 The Author(s).Peer reviewedOxford University Press201420142012info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/92950reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1093/gbe/evs132info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/929502026-05-22T06:33:51Z
dc.title.none.fl_str_mv MicroRNA precursors are not structurally robust but plastic
title MicroRNA precursors are not structurally robust but plastic
spellingShingle MicroRNA precursors are not structurally robust but plastic
Rodrigo, Guillermo
Conformational flexibility
Evolvability
Non-coding RNA
secondary structure
thermodynamics
title_short MicroRNA precursors are not structurally robust but plastic
title_full MicroRNA precursors are not structurally robust but plastic
title_fullStr MicroRNA precursors are not structurally robust but plastic
title_full_unstemmed MicroRNA precursors are not structurally robust but plastic
title_sort MicroRNA precursors are not structurally robust but plastic
dc.creator.none.fl_str_mv Rodrigo, Guillermo
Elena, Santiago F.
author Rodrigo, Guillermo
author_facet Rodrigo, Guillermo
Elena, Santiago F.
author_role author
author2 Elena, Santiago F.
author2_role author
dc.subject.none.fl_str_mv Conformational flexibility
Evolvability
Non-coding RNA
secondary structure
thermodynamics
topic Conformational flexibility
Evolvability
Non-coding RNA
secondary structure
thermodynamics
description Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate nullmodel. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs. © 2012 The Author(s).
publishDate 2012
dc.date.none.fl_str_mv 2012
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/92950
url http://hdl.handle.net/10261/92950
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1093/gbe/evs132
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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