Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in children, causing frequent outpatient visits and hospitalizations. Our study aimed to describe the clinical and direct economic burden of ALRI hospitalizations related to RSV in children in Spain and...

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Autores: Martinón Torres, Federico, Carmo, M., Platero, L., Drago, G., López-Belmonte, J., Bangert, M., Diez Domingo, Javier
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21223
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64995bb471c692789f1e072f
http://hdl.handle.net/20.500.11940/21223
Access Level:acceso abierto
Palabra clave:Infant, Newborn
Infant
Humans
Child
Retrospective Studies
Financial Stress
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Respiratory Syncytial Virus Infections
Hospitalization
Bronchiolitis
Hospitals, Public
AS Santiago
CHUS
IDIS
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spelling Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018Martinón Torres, FedericoCarmo, M.Platero, L.Drago, G.López-Belmonte, J.Bangert, M.Diez Domingo, JavierInfant, NewbornInfantHumansChildRetrospective StudiesFinancial StressRespiratory Syncytial Virus, HumanRespiratory Tract InfectionsRespiratory Syncytial Virus InfectionsHospitalizationBronchiolitisHospitals, PublicAS SantiagoCHUSAS SantiagoIDISRespiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in children, causing frequent outpatient visits and hospitalizations. Our study aimed to describe the clinical and direct economic burden of ALRI hospitalizations related to RSV in children in Spain and the characteristics of patients and their episodes. In this retrospective study, ALRI hospitalizations in children aged < 5 years for 2015-2018 were reviewed using anonymized administrative public hospital discharge data from Spain. Three case definitions were considered: (a) RSV-specific; (b) RSV-specific and unspecified acute bronchiolitis (RSV-specific and bronchiolitis); and (c) RSV-specific and unspecified ALRI (RSV-specific and ALRI). The study reported a mean of 36,743 yearly admissions potentially due to RSV, resulting in a mean annual cost of ?87.1 million. RSV-specific codes accounted for 39.2% of cases, unspecified acute bronchiolitis for 20.1%, and other unspecified ALRI codes for the remaining 40.6%. The mean hospitalization rate per 1,000 children was 55.5 in the first year of life, 16.0 in the second, and 5.4 between 24 and 59 months. A considerable proportion of cases occurred in children under two years old (> 80.4%) and even during the first year of life (> 61.7%). Otherwise healthy children accounted for 92.9% of hospitalizations and 83.3% of costs during the period. Children born preterm accounted for 1.3% of hospitalizations and 5.7% of costs. The findings revealed that RSV still contributes to a high burden on the Spanish health care system. Children under one year of age and otherwise healthy term infants accounted for most of the substantial clinical and economic burden of RSV. Current evidence potentially underestimates the true epidemiology and burden of severe RSV infection; thus, further studies focusing on the outpatient setting are needed.2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/64995bb471c692789f1e072fhttp://hdl.handle.net/20.500.11940/21223reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/212232026-06-12T08:40:47Z
dc.title.none.fl_str_mv Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
title Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
spellingShingle Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
Martinón Torres, Federico
Infant, Newborn
Infant
Humans
Child
Retrospective Studies
Financial Stress
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Respiratory Syncytial Virus Infections
Hospitalization
Bronchiolitis
Hospitals, Public
AS Santiago
CHUS
AS Santiago
IDIS
title_short Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
title_full Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
title_fullStr Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
title_full_unstemmed Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
title_sort Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015-2018
dc.creator.none.fl_str_mv Martinón Torres, Federico
Carmo, M.
Platero, L.
Drago, G.
López-Belmonte, J.
Bangert, M.
Diez Domingo, Javier
author Martinón Torres, Federico
author_facet Martinón Torres, Federico
Carmo, M.
Platero, L.
Drago, G.
López-Belmonte, J.
Bangert, M.
Diez Domingo, Javier
author_role author
author2 Carmo, M.
Platero, L.
Drago, G.
López-Belmonte, J.
Bangert, M.
Diez Domingo, Javier
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Infant, Newborn
Infant
Humans
Child
Retrospective Studies
Financial Stress
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Respiratory Syncytial Virus Infections
Hospitalization
Bronchiolitis
Hospitals, Public
AS Santiago
CHUS
AS Santiago
IDIS
topic Infant, Newborn
Infant
Humans
Child
Retrospective Studies
Financial Stress
Respiratory Syncytial Virus, Human
Respiratory Tract Infections
Respiratory Syncytial Virus Infections
Hospitalization
Bronchiolitis
Hospitals, Public
AS Santiago
CHUS
AS Santiago
IDIS
description Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in children, causing frequent outpatient visits and hospitalizations. Our study aimed to describe the clinical and direct economic burden of ALRI hospitalizations related to RSV in children in Spain and the characteristics of patients and their episodes. In this retrospective study, ALRI hospitalizations in children aged < 5 years for 2015-2018 were reviewed using anonymized administrative public hospital discharge data from Spain. Three case definitions were considered: (a) RSV-specific; (b) RSV-specific and unspecified acute bronchiolitis (RSV-specific and bronchiolitis); and (c) RSV-specific and unspecified ALRI (RSV-specific and ALRI). The study reported a mean of 36,743 yearly admissions potentially due to RSV, resulting in a mean annual cost of ?87.1 million. RSV-specific codes accounted for 39.2% of cases, unspecified acute bronchiolitis for 20.1%, and other unspecified ALRI codes for the remaining 40.6%. The mean hospitalization rate per 1,000 children was 55.5 in the first year of life, 16.0 in the second, and 5.4 between 24 and 59 months. A considerable proportion of cases occurred in children under two years old (> 80.4%) and even during the first year of life (> 61.7%). Otherwise healthy children accounted for 92.9% of hospitalizations and 83.3% of costs during the period. Children born preterm accounted for 1.3% of hospitalizations and 5.7% of costs. The findings revealed that RSV still contributes to a high burden on the Spanish health care system. Children under one year of age and otherwise healthy term infants accounted for most of the substantial clinical and economic burden of RSV. Current evidence potentially underestimates the true epidemiology and burden of severe RSV infection; thus, further studies focusing on the outpatient setting are needed.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/64995bb471c692789f1e072f
http://hdl.handle.net/20.500.11940/21223
url https://portalcientifico.sergas.gal//documentos/64995bb471c692789f1e072f
http://hdl.handle.net/20.500.11940/21223
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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