Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study

Background: Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused on identifying molecular signatures associated with EDCs, but no...

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Autores: Fabbri, L., Garlantézec, R., Audouze, K., Bustamante, M., Carracedo Álvarez, Ángel, Chatzi, L., Ramón González, J., Gra?ulevi?ien?, R., Keun, H., Lau, C.-H.E., Sabidó, E., Siskos, A.P., Slama, R., Thomsen, C., Wright, J., Lun Yuan, W., Casas, M., Vrijheid, M., Maitre, L.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21213
Acceso en línea:https://portalcientifico.sergas.gal//documentos/6416a7b25db420433b7b9fb8
http://hdl.handle.net/20.500.11940/21213
Access Level:acceso abierto
Palabra clave:Child
Humans
Endocrine Disruptors
Leptin
Triclosan
Kynurenine
Multiomics
Serotonin
Environmental Pollutants
FPGMX
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spelling Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel studyFabbri, L.Garlantézec, R.Audouze, K.Bustamante, M.Carracedo Álvarez, ÁngelChatzi, L.Ramón González, J.Gra?ulevi?ien?, R.Keun, H.Lau, C.-H.E.Sabidó, E.Siskos, A.P.Slama, R.Thomsen, C.Wright, J.Lun Yuan, W.Casas, M.Vrijheid, M.Maitre, L.ChildHumansEndocrine DisruptorsLeptinTriclosanKynurenineMultiomicsSerotoninEnvironmental PollutantsFPGMXBackground: Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused on identifying molecular signatures associated with EDCs, but none have used repeated sampling strategy and integrated multiple omics. We aimed to identify multi-omic signatures associated with childhood exposure to non-persistent EDCs. Methods: We used data from the HELIX Child Panel Study, which included 156 children aged 6 to 11. Children were followed for one week, in two time periods. Twenty-two non-persistent EDCs (10 phthalate, 7 phenol, and 5 organophosphate pesticide metabolites) were measured in two weekly pools of 15 urine samples each. Multi-omic profiles (methylome, serum and urinary metabolome, proteome) were measured in blood and in a pool urine samples. We developed visit-specific Gaussian Graphical Models based on pairwise partial correlations. The visit-specific networks were then merged to identify reproducible associations. Independent biological evidence was systematically sought to confirm some of these associations and assess their potential health implications. Results: 950 reproducible associations were found among which 23 were direct associations between EDCs and omics. For 9 of them, we were able to find corroborating evidence from previous literature: DEP - serotonin, OXBE - cg27466129, OXBE - dimethylamine, triclosan - leptin, triclosan - serotonin, MBzP - Neu5AC, MEHP - cg20080548, oh-MiNP - kynurenine, oxo-MiNP ? 5-oxoproline. We used these associations to explore possible mechanisms between EDCs and health outcomes, and found links to health outcomes for 3 analytes: serotonin and kynurenine in relation to neuro-behavioural development, and leptin in relation to obesity and insulin resistance. Conclusions: This multi-omics network analysis at two time points identified biologically relevant molecular signatures related to non-persistent EDC exposure in childhood, suggesting pathways related to neurological and metabolic outcomes.Funding This work was funded by the European Union?s Horizon 2020 research and innovation programme OBERON project (grant agreement 825712 and its annexes) .2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/6416a7b25db420433b7b9fb8http://hdl.handle.net/20.500.11940/21213reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/212132026-06-12T08:40:47Z
dc.title.none.fl_str_mv Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
title Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
spellingShingle Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
Fabbri, L.
Child
Humans
Endocrine Disruptors
Leptin
Triclosan
Kynurenine
Multiomics
Serotonin
Environmental Pollutants
FPGMX
title_short Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
title_full Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
title_fullStr Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
title_full_unstemmed Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
title_sort Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
dc.creator.none.fl_str_mv Fabbri, L.
Garlantézec, R.
Audouze, K.
Bustamante, M.
Carracedo Álvarez, Ángel
Chatzi, L.
Ramón González, J.
Gra?ulevi?ien?, R.
Keun, H.
Lau, C.-H.E.
Sabidó, E.
Siskos, A.P.
Slama, R.
Thomsen, C.
Wright, J.
Lun Yuan, W.
Casas, M.
Vrijheid, M.
Maitre, L.
author Fabbri, L.
author_facet Fabbri, L.
Garlantézec, R.
Audouze, K.
Bustamante, M.
Carracedo Álvarez, Ángel
Chatzi, L.
Ramón González, J.
Gra?ulevi?ien?, R.
Keun, H.
Lau, C.-H.E.
Sabidó, E.
Siskos, A.P.
Slama, R.
Thomsen, C.
Wright, J.
Lun Yuan, W.
Casas, M.
Vrijheid, M.
Maitre, L.
author_role author
author2 Garlantézec, R.
Audouze, K.
Bustamante, M.
Carracedo Álvarez, Ángel
Chatzi, L.
Ramón González, J.
Gra?ulevi?ien?, R.
Keun, H.
Lau, C.-H.E.
Sabidó, E.
Siskos, A.P.
Slama, R.
Thomsen, C.
Wright, J.
Lun Yuan, W.
Casas, M.
Vrijheid, M.
Maitre, L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Child
Humans
Endocrine Disruptors
Leptin
Triclosan
Kynurenine
Multiomics
Serotonin
Environmental Pollutants
FPGMX
topic Child
Humans
Endocrine Disruptors
Leptin
Triclosan
Kynurenine
Multiomics
Serotonin
Environmental Pollutants
FPGMX
description Background: Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused on identifying molecular signatures associated with EDCs, but none have used repeated sampling strategy and integrated multiple omics. We aimed to identify multi-omic signatures associated with childhood exposure to non-persistent EDCs. Methods: We used data from the HELIX Child Panel Study, which included 156 children aged 6 to 11. Children were followed for one week, in two time periods. Twenty-two non-persistent EDCs (10 phthalate, 7 phenol, and 5 organophosphate pesticide metabolites) were measured in two weekly pools of 15 urine samples each. Multi-omic profiles (methylome, serum and urinary metabolome, proteome) were measured in blood and in a pool urine samples. We developed visit-specific Gaussian Graphical Models based on pairwise partial correlations. The visit-specific networks were then merged to identify reproducible associations. Independent biological evidence was systematically sought to confirm some of these associations and assess their potential health implications. Results: 950 reproducible associations were found among which 23 were direct associations between EDCs and omics. For 9 of them, we were able to find corroborating evidence from previous literature: DEP - serotonin, OXBE - cg27466129, OXBE - dimethylamine, triclosan - leptin, triclosan - serotonin, MBzP - Neu5AC, MEHP - cg20080548, oh-MiNP - kynurenine, oxo-MiNP ? 5-oxoproline. We used these associations to explore possible mechanisms between EDCs and health outcomes, and found links to health outcomes for 3 analytes: serotonin and kynurenine in relation to neuro-behavioural development, and leptin in relation to obesity and insulin resistance. Conclusions: This multi-omics network analysis at two time points identified biologically relevant molecular signatures related to non-persistent EDC exposure in childhood, suggesting pathways related to neurological and metabolic outcomes.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/6416a7b25db420433b7b9fb8
http://hdl.handle.net/20.500.11940/21213
url https://portalcientifico.sergas.gal//documentos/6416a7b25db420433b7b9fb8
http://hdl.handle.net/20.500.11940/21213
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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