Exudative versus nonexudative age-related macular d generation: physiopathology and treatment options

Age-related macular degeneration (AMD) is an eye disease typically associated with the aging and can be classified into two types—namely, the exudative and the nonexudative AMD. Currently available treatments for exudative AMD use intravitreal injections, which are associated with high risk of infec...

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Detalles Bibliográficos
Autores: Fernandes, Ana Rita, Zielinska, Aleksandra, Sánchez-López, E. (Elena), Santos, Tiago dos, García López, María Luisa, Silva, Amélia M., Karczewski, Jacek, Souto, Eliana B.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/204185
Acceso en línea:https://hdl.handle.net/2445/204185
Access Level:acceso abierto
Palabra clave:Oftalmologia geriàtrica
Oftalmopaties
Geriatric ophthalmology
Ophthalmopathies
Descripción
Sumario:Age-related macular degeneration (AMD) is an eye disease typically associated with the aging and can be classified into two types—namely, the exudative and the nonexudative AMD. Currently available treatments for exudative AMD use intravitreal injections, which are associated with high risk of infection that can lead to endophthalmitis, while no successful treatments yet exist for the nonexudative form of AMD. In addition to the pharmacologic therapies administered by intravitreal injection already approved by the Food and Drug Administration (FDA) in exudative AMD, there are some laser treatments approved that can be used in combination with the pharmacological therapies. In this review, we discuss the latest developments of treatment options for AMD. Relevant literature available from 1993 was used, which included original articles and reviews available in PubMed database and also information collected from Clinical Trials Gov website using “age-related macular degeneration” and “antiangiogenic therapies” as keywords. The clinical trials search was limited to ongoing trials from 2015 to date.