Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study
Background: Chagas disease is a parasitic disease endemic to Latin America, but it has become a disease of global concern due to migration flows. Asymptomatic carriers may host the parasite for years, without knowing they are infected. The aim of this study is to assess prevalence of Chagas disease...
| Autores: | , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
| Repositorio: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| OAI Identifier: | oai:isabial.fundanetsuite.com:p7341 |
| Acceso en línea: | https://isabial.portalinvestigacion.com/publicaciones7341 |
| Access Level: | acceso abierto |
| Palabra clave: | Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening |
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Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational studyRamos-Sesma, VioletaNavarro, MiriamLlenas-Garcia, JaraGil-Anguita, ConcepcionTorrus-Tendero, DiegoWikman-Jorgensen, PhilipGarcia-Lopez, MariaAmador-Prous, ConcepcionVentero-Martin, Maria-PazGuevara-Hernandez, PedroGarijo-Saiz, AnaSanchez-Sanchez, AresBernal-Alcaraz, CristinaPujades-Tarraga, Ana-IsabelMunoz-Perez, RoserFlores-Chavez, MariaRamos-Rincon, Jose-ManuelCorazonesSinChagas PlatformChagas diseaseTrypanosoma cruziKnowledgeCommunity-based interventionMigrantEarly diagnosisScreeningBackground: Chagas disease is a parasitic disease endemic to Latin America, but it has become a disease of global concern due to migration flows. Asymptomatic carriers may host the parasite for years, without knowing they are infected. The aim of this study is to assess prevalence of Chagas disease and evaluate the participants' level of knowledge between Latin American migrants attending a community-based screening campaign. Methods: Three community-based campaigns were performed in Alicante (Spain) in 2016, 2017 and 2018, including educational chats and blood tests for Trypanosoma cruzi serology. Participants completed a questionnaire assessing knowledge about the mechanisms of transmission, disease presentation, diagnosis, and treatment. People seropositive for T. cruzi underwent diagnostic confirmation by two different tests. Results were analyzed by multivariable logistic regression and expressed as adjusted odds ratios (aORs), adjusting for age, sex, and time in Spain. Results: A total of 596 participants were included in the study; 17% were aged under 18 years. Prevalence in adults was 11% [54/496; 95% confidence interval (CI): 8.3-14.5%] versus 0% among children. All but one case were in Bolivians. Diagnosis was independently associated with having been born in Bolivia (aOR: 102, 95% CI: 13-781) and a primary school-level education (aOR: 2.40, 95% CI: 1.14-5.06). Of 54 people diagnosed with Chagas disease (most of whom were asymptomatic), 42 (77.7%) returned to the clinic at least once, and 24 (44.4%) received treatment. Multivariable analysis showed that coming from Argentina (aOR: 13, 95% CI: 1.61-1188) or Bolivia (aOR: 1.90, 95% CI: 1.19-3.39) and having received information about Chagas disease in Spain (aOR: 4.63, 95% CI: 2.54-8.97) were associated with a good level of knowledge on the disease. Having primary level studies (aOR: 0.59, 95% CI: 0.34-0.98) and coming from Ecuador (aOR: 4.63, 95% CI: 2.52-847) were independently associated with a lower level of knowledge. Conclusions: Community-based interventions are a good strategy for diagnosing neglected diseases such as Chagas disease in non-endemic countries and for identifying and treating infected, asymptomatic individuals. Graphic abstractBMC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones7341Infectious Diseases of PovertyISSN: 20955162ISSNe: 20499957reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p73412026-06-12T10:20:37Z |
| dc.title.none.fl_str_mv |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| title |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| spellingShingle |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study Ramos-Sesma, Violeta Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening |
| title_short |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| title_full |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| title_fullStr |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| title_full_unstemmed |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| title_sort |
Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study |
| dc.creator.none.fl_str_mv |
Ramos-Sesma, Violeta Navarro, Miriam Llenas-Garcia, Jara Gil-Anguita, Concepcion Torrus-Tendero, Diego Wikman-Jorgensen, Philip Garcia-Lopez, Maria Amador-Prous, Concepcion Ventero-Martin, Maria-Paz Guevara-Hernandez, Pedro Garijo-Saiz, Ana Sanchez-Sanchez, Ares Bernal-Alcaraz, Cristina Pujades-Tarraga, Ana-Isabel Munoz-Perez, Roser Flores-Chavez, Maria Ramos-Rincon, Jose-Manuel CorazonesSinChagas Platform |
| author |
Ramos-Sesma, Violeta |
| author_facet |
Ramos-Sesma, Violeta Navarro, Miriam Llenas-Garcia, Jara Gil-Anguita, Concepcion Torrus-Tendero, Diego Wikman-Jorgensen, Philip Garcia-Lopez, Maria Amador-Prous, Concepcion Ventero-Martin, Maria-Paz Guevara-Hernandez, Pedro Garijo-Saiz, Ana Sanchez-Sanchez, Ares Bernal-Alcaraz, Cristina Pujades-Tarraga, Ana-Isabel Munoz-Perez, Roser Flores-Chavez, Maria Ramos-Rincon, Jose-Manuel CorazonesSinChagas Platform |
| author_role |
author |
| author2 |
Navarro, Miriam Llenas-Garcia, Jara Gil-Anguita, Concepcion Torrus-Tendero, Diego Wikman-Jorgensen, Philip Garcia-Lopez, Maria Amador-Prous, Concepcion Ventero-Martin, Maria-Paz Guevara-Hernandez, Pedro Garijo-Saiz, Ana Sanchez-Sanchez, Ares Bernal-Alcaraz, Cristina Pujades-Tarraga, Ana-Isabel Munoz-Perez, Roser Flores-Chavez, Maria Ramos-Rincon, Jose-Manuel CorazonesSinChagas Platform |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening |
| topic |
Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening |
| description |
Background: Chagas disease is a parasitic disease endemic to Latin America, but it has become a disease of global concern due to migration flows. Asymptomatic carriers may host the parasite for years, without knowing they are infected. The aim of this study is to assess prevalence of Chagas disease and evaluate the participants' level of knowledge between Latin American migrants attending a community-based screening campaign. Methods: Three community-based campaigns were performed in Alicante (Spain) in 2016, 2017 and 2018, including educational chats and blood tests for Trypanosoma cruzi serology. Participants completed a questionnaire assessing knowledge about the mechanisms of transmission, disease presentation, diagnosis, and treatment. People seropositive for T. cruzi underwent diagnostic confirmation by two different tests. Results were analyzed by multivariable logistic regression and expressed as adjusted odds ratios (aORs), adjusting for age, sex, and time in Spain. Results: A total of 596 participants were included in the study; 17% were aged under 18 years. Prevalence in adults was 11% [54/496; 95% confidence interval (CI): 8.3-14.5%] versus 0% among children. All but one case were in Bolivians. Diagnosis was independently associated with having been born in Bolivia (aOR: 102, 95% CI: 13-781) and a primary school-level education (aOR: 2.40, 95% CI: 1.14-5.06). Of 54 people diagnosed with Chagas disease (most of whom were asymptomatic), 42 (77.7%) returned to the clinic at least once, and 24 (44.4%) received treatment. Multivariable analysis showed that coming from Argentina (aOR: 13, 95% CI: 1.61-1188) or Bolivia (aOR: 1.90, 95% CI: 1.19-3.39) and having received information about Chagas disease in Spain (aOR: 4.63, 95% CI: 2.54-8.97) were associated with a good level of knowledge on the disease. Having primary level studies (aOR: 0.59, 95% CI: 0.34-0.98) and coming from Ecuador (aOR: 4.63, 95% CI: 2.52-847) were independently associated with a lower level of knowledge. Conclusions: Community-based interventions are a good strategy for diagnosing neglected diseases such as Chagas disease in non-endemic countries and for identifying and treating infected, asymptomatic individuals. Graphic abstract |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://isabial.portalinvestigacion.com/publicaciones7341 |
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https://isabial.portalinvestigacion.com/publicaciones7341 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BMC |
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BMC |
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Infectious Diseases of Poverty ISSN: 20955162 ISSNe: 20499957 reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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