2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk

[EN]Lactose isthe preeminent soluble glycan in milk and a significant source of energy for most newborn mammals. Elongation of lactose with additional monosaccharides gives rise to a varied repertoire of free soluble glycans such as 2′-fucosyllactose (2′-FL), which is the most abundant oligosacchari...

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Detalles Bibliográficos
Autores: Castanys-Muñoz, Esther, Martín Martín, María Jesús, Prieto, Pedro Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/167856
Acceso en línea:http://hdl.handle.net/10366/167856
Access Level:acceso abierto
Palabra clave:2′-fucosyllactose
Breastfeeding
oligosaccharides
Prebiotic
Glycans
Milk
3206 Ciencias de la Nutrición
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spelling 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milkCastanys-Muñoz, EstherMartín Martín, María JesúsPrieto, Pedro Antonio2′-fucosyllactoseBreastfeedingoligosaccharidesPrebioticGlycansMilk3206 Ciencias de la Nutrición[EN]Lactose isthe preeminent soluble glycan in milk and a significant source of energy for most newborn mammals. Elongation of lactose with additional monosaccharides gives rise to a varied repertoire of free soluble glycans such as 2′-fucosyllactose (2′-FL), which is the most abundant oligosaccharide in human milk. In infants, 2′-FL is resistant to digestion and reaches the colon where it is partially fermented, behaving as soluble prebiotic fiber. Evidence also suggests that portions of small soluble milk glycans, including 2′-FL, are absorbed, thus raising the possibility of systemic biological effects. 2′-FL bears an epitope of the Secretor histo-blood group system; approximately 70–80% of all milk samples contain 2′-FL, since its synthesis depends on a fucosyltransferase that is not uniformly expressed. The fact that some infants are not exposed to 2′-FL has helped researchers to retrospectively probe for biological activities of this glycan. This review summarizes the attributes of 2′-FL in terms of its occurrence in mammalian phylogeny, its postulated biological activities, and its variability in human milk.Abbott LaboratoriesAbbott Laboratories202520252013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/167856reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1678562026-06-07T06:28:51Z
dc.title.none.fl_str_mv 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
title 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
spellingShingle 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
Castanys-Muñoz, Esther
2′-fucosyllactose
Breastfeeding
oligosaccharides
Prebiotic
Glycans
Milk
3206 Ciencias de la Nutrición
title_short 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
title_full 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
title_fullStr 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
title_full_unstemmed 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
title_sort 2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
dc.creator.none.fl_str_mv Castanys-Muñoz, Esther
Martín Martín, María Jesús
Prieto, Pedro Antonio
author Castanys-Muñoz, Esther
author_facet Castanys-Muñoz, Esther
Martín Martín, María Jesús
Prieto, Pedro Antonio
author_role author
author2 Martín Martín, María Jesús
Prieto, Pedro Antonio
author2_role author
author
dc.subject.none.fl_str_mv 2′-fucosyllactose
Breastfeeding
oligosaccharides
Prebiotic
Glycans
Milk
3206 Ciencias de la Nutrición
topic 2′-fucosyllactose
Breastfeeding
oligosaccharides
Prebiotic
Glycans
Milk
3206 Ciencias de la Nutrición
description [EN]Lactose isthe preeminent soluble glycan in milk and a significant source of energy for most newborn mammals. Elongation of lactose with additional monosaccharides gives rise to a varied repertoire of free soluble glycans such as 2′-fucosyllactose (2′-FL), which is the most abundant oligosaccharide in human milk. In infants, 2′-FL is resistant to digestion and reaches the colon where it is partially fermented, behaving as soluble prebiotic fiber. Evidence also suggests that portions of small soluble milk glycans, including 2′-FL, are absorbed, thus raising the possibility of systemic biological effects. 2′-FL bears an epitope of the Secretor histo-blood group system; approximately 70–80% of all milk samples contain 2′-FL, since its synthesis depends on a fucosyltransferase that is not uniformly expressed. The fact that some infants are not exposed to 2′-FL has helped researchers to retrospectively probe for biological activities of this glycan. This review summarizes the attributes of 2′-FL in terms of its occurrence in mammalian phylogeny, its postulated biological activities, and its variability in human milk.
publishDate 2013
dc.date.none.fl_str_mv 2013
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/167856
url http://hdl.handle.net/10366/167856
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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