International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis
Background & Aims Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, prevalence, tolerability, and outcome of sorafenib in this pop...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| Repositorio: | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| OAI Identifier: | oai:i3pt.fundanetsuite.com:p2663 |
| Acceso en línea: | https://i3pt.portalinvestigacion.com/publicaciones/2663 |
| Access Level: | acceso abierto |
| Palabra clave: | adverse events dialysis Hepatocellular carcinoma safety sorafenib survival |
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International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysisDiaz-Gonzalez, ASanduzzi-Zamparelli, MFonseca, LGDi Costanzo, GGAlves, RIavarone, MLeal, CSacco, RMatilla, AMHernandez-Guerra, MSoteras, GAWorns, MAPinter, MVarela, MLadekarl, MChagas, ALMinguez, BArenas, JIGranito, ASanchez-Torrijos, YRojas, Ade Lope, CRAlvares-da-Silva, MRPascual, SRimassa, LLledo, JLHuertas, CSangro, BGiannini, EGDelgado, MVergara, MPerello, CLue, ASala, MGallego, AColl, SHernaez, TPinero, FPereira, GFranca, AMarin, JAnders, MMello, VLozano, MNault, JCMenendez, JJuarez, IGBruix, JReig, Madverse eventsdialysisHepatocellular carcinomasafetysorafenibsurvivalBackground & Aims Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, prevalence, tolerability, and outcome of sorafenib in this population. Methods We report a multicenter study comprising patients from Latin America and Europe. Patients treated with sorafenib were enrolled; demographics, dose modifications, adverse events (AEs), treatment duration, and outcome of patients undergoing dialysis were recorded. Results As of March 2018, 6156 HCC patients were treated in 44 centres and 22 patients were concomitantly under dialysis (0.36%). The median age was 65.5 years, 40.9% had hepatitis C, 75% had Child-Pugh A, and 85% were Barcelona Clinic Liver Cancer-C. The median time to first dose modification, treatment duration and overall survival rate were 2.4 months (interquartile ranges [IQR], 0.8-3.8), 10.8 months (IQR, 4.5-16.9), and 17.5 months (95% CI, 7.2-24.5), respectively. Seventeen patients required at least 1 dose modification. The main causes of first dose modification were asthenia/worsening of Eastern Cooperative Oncology Group-Performance Status and diarrhoea. At the time of death or last follow-up, four patients were still on treatment and 18 had discontinued sorafenib: 14 were due to tumour progression, 2 were sorafenib-related, and 2 were non-sorafenib-related AE. Conclusions The outcomes observed in this cohort seem comparable to those in the non-dialysis population. Thus, to the best of our knowledge, this is the largest and most informative dataset regarding systemic treatment outcomes in HCC patients undergoing dialysis.WILEY2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/2663LIVER INTERNATIONALISSN: 14783223ISSNe: 14783231reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p26632026-06-21T15:30:37Z |
| dc.title.none.fl_str_mv |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| title |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| spellingShingle |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis Diaz-Gonzalez, A adverse events dialysis Hepatocellular carcinoma safety sorafenib survival |
| title_short |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| title_full |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| title_fullStr |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| title_full_unstemmed |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| title_sort |
International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis |
| dc.creator.none.fl_str_mv |
Diaz-Gonzalez, A Sanduzzi-Zamparelli, M Fonseca, LG Di Costanzo, GG Alves, R Iavarone, M Leal, C Sacco, R Matilla, AM Hernandez-Guerra, M Soteras, GA Worns, MA Pinter, M Varela, M Ladekarl, M Chagas, AL Minguez, B Arenas, JI Granito, A Sanchez-Torrijos, Y Rojas, A de Lope, CR Alvares-da-Silva, MR Pascual, S Rimassa, L Lledo, JL Huertas, C Sangro, B Giannini, EG Delgado, M Vergara, M Perello, C Lue, A Sala, M Gallego, A Coll, S Hernaez, T Pinero, F Pereira, G Franca, A Marin, J Anders, M Mello, V Lozano, M Nault, JC Menendez, J Juarez, IG Bruix, J Reig, M |
| author |
Diaz-Gonzalez, A |
| author_facet |
Diaz-Gonzalez, A Sanduzzi-Zamparelli, M Fonseca, LG Di Costanzo, GG Alves, R Iavarone, M Leal, C Sacco, R Matilla, AM Hernandez-Guerra, M Soteras, GA Worns, MA Pinter, M Varela, M Ladekarl, M Chagas, AL Minguez, B Arenas, JI Granito, A Sanchez-Torrijos, Y Rojas, A de Lope, CR Alvares-da-Silva, MR Pascual, S Rimassa, L Lledo, JL Huertas, C Sangro, B Giannini, EG Delgado, M Vergara, M Perello, C Lue, A Sala, M Gallego, A Coll, S Hernaez, T Pinero, F Pereira, G Franca, A Marin, J Anders, M Mello, V Lozano, M Nault, JC Menendez, J Juarez, IG Bruix, J Reig, M |
| author_role |
author |
| author2 |
Sanduzzi-Zamparelli, M Fonseca, LG Di Costanzo, GG Alves, R Iavarone, M Leal, C Sacco, R Matilla, AM Hernandez-Guerra, M Soteras, GA Worns, MA Pinter, M Varela, M Ladekarl, M Chagas, AL Minguez, B Arenas, JI Granito, A Sanchez-Torrijos, Y Rojas, A de Lope, CR Alvares-da-Silva, MR Pascual, S Rimassa, L Lledo, JL Huertas, C Sangro, B Giannini, EG Delgado, M Vergara, M Perello, C Lue, A Sala, M Gallego, A Coll, S Hernaez, T Pinero, F Pereira, G Franca, A Marin, J Anders, M Mello, V Lozano, M Nault, JC Menendez, J Juarez, IG Bruix, J Reig, M |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
adverse events dialysis Hepatocellular carcinoma safety sorafenib survival |
| topic |
adverse events dialysis Hepatocellular carcinoma safety sorafenib survival |
| description |
Background & Aims Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, prevalence, tolerability, and outcome of sorafenib in this population. Methods We report a multicenter study comprising patients from Latin America and Europe. Patients treated with sorafenib were enrolled; demographics, dose modifications, adverse events (AEs), treatment duration, and outcome of patients undergoing dialysis were recorded. Results As of March 2018, 6156 HCC patients were treated in 44 centres and 22 patients were concomitantly under dialysis (0.36%). The median age was 65.5 years, 40.9% had hepatitis C, 75% had Child-Pugh A, and 85% were Barcelona Clinic Liver Cancer-C. The median time to first dose modification, treatment duration and overall survival rate were 2.4 months (interquartile ranges [IQR], 0.8-3.8), 10.8 months (IQR, 4.5-16.9), and 17.5 months (95% CI, 7.2-24.5), respectively. Seventeen patients required at least 1 dose modification. The main causes of first dose modification were asthenia/worsening of Eastern Cooperative Oncology Group-Performance Status and diarrhoea. At the time of death or last follow-up, four patients were still on treatment and 18 had discontinued sorafenib: 14 were due to tumour progression, 2 were sorafenib-related, and 2 were non-sorafenib-related AE. Conclusions The outcomes observed in this cohort seem comparable to those in the non-dialysis population. Thus, to the best of our knowledge, this is the largest and most informative dataset regarding systemic treatment outcomes in HCC patients undergoing dialysis. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://i3pt.portalinvestigacion.com/publicaciones/2663 |
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https://i3pt.portalinvestigacion.com/publicaciones/2663 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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WILEY |
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WILEY |
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LIVER INTERNATIONAL ISSN: 14783223 ISSNe: 14783231 reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí instname:Institut d'Investigació i Innovació Parc Taulí (I3PT) |
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Institut d'Investigació i Innovació Parc Taulí (I3PT) |
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r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
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r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
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